Jayson W. Jay
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View article: Bovine Dermal Collagen Matrix Promotes Vascularized Tissue Generation Supporting Early Definitive Closure in Full-Thickness Wounds: A Pre-clinical Study
Bovine Dermal Collagen Matrix Promotes Vascularized Tissue Generation Supporting Early Definitive Closure in Full-Thickness Wounds: A Pre-clinical Study Open
[This corrects the article DOI: 10.7759/cureus.81517.].
View article: Therapeutic Strategies to Reduce Burn Wound Conversion
Therapeutic Strategies to Reduce Burn Wound Conversion Open
Burn wound conversion refers to the phenomenon whereby superficial burns that appear to retain the ability to spontaneously heal, convert later into deeper wounds in need of excision. While no current treatment can definitively stop burn w…
View article: Galunisertib Exerts Antifibrotic Effects on TGF-β-Induced Fibroproliferative Dermal Fibroblasts
Galunisertib Exerts Antifibrotic Effects on TGF-β-Induced Fibroproliferative Dermal Fibroblasts Open
Dermal fibroblasts in pathological scars secrete constitutively elevated levels of TGF-β, signaling the transcription of fibrotic genes via activin-like kinase 5 (ALK5). In the present study, we examine the antifibrotic effects of galunise…
View article: 101 Adrenergic Receptor Expression Is Increased in Carotid Smooth Muscle from Severely Burned Rats
101 Adrenergic Receptor Expression Is Increased in Carotid Smooth Muscle from Severely Burned Rats Open
Introduction Severe burn disrupts cardiovascular function which can lead to critical shock. To counteract cardiovascular collapse, there is a systemic increase of catecholamines released in response to severe burn. Previous studies showed …
View article: Current Approaches Targeting the Wound Healing Phases to Attenuate Fibrosis and Scarring
Current Approaches Targeting the Wound Healing Phases to Attenuate Fibrosis and Scarring Open
Cutaneous fibrosis results from suboptimal wound healing following significant tissue injury such as severe burns, trauma, and major surgeries. Pathologic skin fibrosis results in scars that are disfiguring, limit normal movement, and prev…