JC Lau
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P.076 Long-term outcomes of radiofrequency ablation for temporal lobe epilepsy Open
Background: Radiofrequency ablation (RFA) is a minimally-invasive procedure that has been used to treat temporal lobe epilepsy (TLE), however its long-term efficacy is unknown. We aim to characterize the long-term outcomes of patients from…
P.133 Neurons in the lateral prefrontal cortex encode task features during virtual navigation Open
Background: The lateral prefrontal cortex (LPFC) is uniquely found in primates and has been associated with contextual learning. This function is thought to be subserved by neurons that are tuned to abstract concepts and the combination of…
P.116 Anatomical fiducials used to quantify localization and registration accuracy in deep brain stimulation Open
Background: Studies of deep brain stimulation (DBS) require accurate electrode localization and image registration. We used anatomical fiducials to investigate localization and registration errors in patients who underwent subthalamic nucl…
P.161 Spatiotemporal dynamics of neuronal ensembles in the primate prefrontal cortex during virtual reality navigation tasks Open
Background: Brain-machine-interface research has utilized multichannel single neuron recordings to decode movement intention. However, the prefrontal cortex (PFC) contains mental representations of more abstract task and goal elements whic…
P.124 Subnuclear contact localization within the subthalamic nucleus in deep brain stimulation for Parkinson Disease Open
Background: Therapeutic response from subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson disease (PD) has been associated with proximity to an ideal target, commonly in the dorsal sensorimotor STN. Automated registration …
P.157 Frame-based stereotactic brain biopsy: A retrospective review of diagnostic yield and complications at a Canadian Center Open
Background: Historically, frame-based stereotactic brain biopsy (SBB) has played an important role in the diagnosis of intracranial lesions. We performed a single centre analysis of the outcomes and efficacy of SBB at the London Health Sci…
P.201 Disruption of the Frontal Aslant Tract is Associated with Transient Aphasia and not Agraphia: A Neurosurgical Case Report Open
Background: The frontal aslant tract (FAT) is a recently discovered white-matter tract connecting the medial superior frontal gyrus to the inferior frontal gyrus. There is increasing evidence for its importance in speech initiation and pro…
P.167 Application of the Anatomical Fiducials Framework to a Clinical Dataset of Patients with Parkinson’s Disease Open
Background: Establishing spatial correspondence between subject and template images is necessary in neuroimaging research and clinical applications. A point-based set of anatomical fiducials (AFIDs) was recently developed and validated to …
P.175 Direct Visualization of Thalamic Nuclei using 7 Tesla MRI and quantification in patients with temporal lobe epilepsy. Open
Background: Most individual thalamic nuclei cannot be directly visualized on routine clinical MRI. Stereotactic targeting techniques are indirect, relying on histological atlases and electrophysiological recording. We investigate whether h…
C.03 Deformation-based morphometry analysis of longitudinal low-grade glioma growth Open
Background: Diffuse low-grade gliomas (LGGs) are primary brain tumours with infiltrative, anisotropic growth related to surrounding white and grey matter structures. Deformation-based morphometry (DBM) is a simple and objective image analy…
P.083 Radiology reporting of low-grade glioma growth underestimates tumor expansion Open
Background: Surveillance by serial magnetic resonance imaging (MRI) is important in the management of diffuse low-grade gliomas (LGGs). Radiological interpretations of LGG scans, however, are typically qualitative and difficult to use clin…
P.043 Volumetric analysis of low-grade glioma growth in serially-imaged patients Open
Background: Diffuse low-grade gliomas (LGGs) are infiltrative, slow-growing primary brain tumors that remain relatively asymptomatic for long periods of time before progressing to aggressive high-grade gliomas. Methods: We retrospectively …
View article: C.03 Surgical complications with and without image guidance: meta-analysis of Ommaya reservoir insertions
C.03 Surgical complications with and without image guidance: meta-analysis of Ommaya reservoir insertions Open
Background: There remains an important role for consolidating evidence on the utility of image guidance (IG) in neurosurgery. In 1963, Ayub Ommaya proposed a surgical technique for the -placement of a subcutaneous reservoir and pump to all…
P.063 Stereotactic targeting of hippocampal substructures using ultra-high field magnetic resonance imaging: Feasibility study in patients with epilepsy Open
Background : The hippocampus can be divided longitudinally into the head, body, and tail; and unfolded medial-to-laterally into the subiculum, cornu ammonis (CA) sectors, and the dentate gyrus. Ultra-high field (≥ 7 Tesla; 7T) magnetic res…
P.035 Correlation of thalamic connectivity with the duration of epilepsy in patients with temporal lobe epilepsy Open
Background: Morphometry and connectivity studies targeting the thalamus have revealed specific patterns of atrophy and deafferentiation in patients with temporal lobe epilepsy (TLE). We used probabilistic tractography to investigate thalam…
P.083 Characterization of an arteriovenous malformation using 7T structural and functional imaging: A case report Open
Background: Cerebral arteriovenous malformations (AVMs) are a type of vascular abnormality characterized by abnormal connections between arteries and veins without the normal interposed capillary bed. The gold standard for diagnosis is dig…
P.092 Ommaya reservoir placement for intraventricular chemotherapy: a retrospective case series in the image-guidance era Open
Background: In 1963, Ayub Ommaya proposed a surgical technique for placement of a subcutaneous reservoir and pump to allow access to intraventricular cerebrospinal fluid (CSF). Currently, the most common indication for Ommaya reservoir ins…
P.105 Clinical impact of functional magnetic resonance imaging for pre-operative planning in patients with low grade gliomas Open
Background: This study aims to evaluate the impact of pre-operative functional magnetic resonance imaging (fMRI) on low grade glioma (LGG) patients’ outcomes. Methods: In this retrospective matched cohort study (N =48) of a single surgeon’…
P.012 Spinal durotomy repair simulator for deliberate microsurgical practice: integration into a residency training module Open
Background: Deliberate practice is one aspect of gaining competency in surgical skills. We have previously integrated a vascular microsurgery module into our residency training curriculum, and have recently described our experience with co…