Jean Bastié
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View article: Assessing the benefit of incorporating an anti-CD38 monoclonal antibody into second- or third-line systemic treatment for patients with relapsed/refractory multiple myeloma: results from the French real-world EMMY study
Assessing the benefit of incorporating an anti-CD38 monoclonal antibody into second- or third-line systemic treatment for patients with relapsed/refractory multiple myeloma: results from the French real-world EMMY study Open
Not available.
View article: High Fluorescent Lymphoid Cell Levels Assessed on Initial Blood Count in Newly Diagnosed Multiple Myeloma Carry Prognostic Significance
High Fluorescent Lymphoid Cell Levels Assessed on Initial Blood Count in Newly Diagnosed Multiple Myeloma Carry Prognostic Significance Open
The outcome of multiple myeloma (MM) has tremendously improved over the past decade, due to the development of efficient chemotherapy and mostly immunotherapy. Yet, some patients still display poor responses and outcome. This could be in p…
View article: L’arginine méthyltransférase PRMT2 est impliquée dans le contrôle de l’inflammation des leucémies aiguës myéloblastiques
L’arginine méthyltransférase PRMT2 est impliquée dans le contrôle de l’inflammation des leucémies aiguës myéloblastiques Open
View article: Clinical outcomes in patients in any phase of <scp>CML</scp> treated with ponatinib in France—Data from the <scp>TOPASE</scp> observational study
Clinical outcomes in patients in any phase of <span>CML</span> treated with ponatinib in France—Data from the <span>TOPASE</span> observational study Open
Summary The TOPASE study was set up to evaluate the outcomes of chronic myeloid leukaemia [CML] patients treated with ponatinib (PON) in a real‐world setting in France. One hundred and twenty CML patients, 105 in chronic phase (CP), 8 in a…
View article: Faire vivre et grandir une communauté de chefs de service : acte 2 en hématologie
Faire vivre et grandir une communauté de chefs de service : acte 2 en hématologie Open
In response to the French hospital system crisis and the challenges faced by the heads of departments, we have undertaken an initiative to create a community of heads of haematology departments willing to assist each other. Our inaugural s…
View article: Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia Open
View article: Prognostic value of postinduction medullary myeloid recovery by flow cytometry in acute myeloid leukemia
Prognostic value of postinduction medullary myeloid recovery by flow cytometry in acute myeloid leukemia Open
Risk stratification and treatment response evaluation are key features in acute myeloid leukemia (AML) management. Immunophenotypic and molecular approaches all rely on the detection of persisting leukemic cells by measurable residual dise…
View article: Prognostic value of post-induction medullary myeloid recovery by flow cytometry in acute myeloid leukemia
Prognostic value of post-induction medullary myeloid recovery by flow cytometry in acute myeloid leukemia Open
Risk stratification and treatment response evaluation are key features in acute myeloid leukemia (AML) management. Immunophenotypic and molecular approaches all rely on the detection of persisting leukemic cells by measurable residual dise…
View article: Influence of Sociodemographic Determinants on the Hodgkin Lymphoma Baseline Characteristics in Long Survivors Patients Enrolled in the Prospective Phase 3 Trial AHL2011
Influence of Sociodemographic Determinants on the Hodgkin Lymphoma Baseline Characteristics in Long Survivors Patients Enrolled in the Prospective Phase 3 Trial AHL2011 Open
Introduction: Whereas numerous studies on several cancers describe the link between social conditions and disease severity, little is known about the social and demographic characteristics of Hodgkin lymphoma (HL) patients. At diagnosis, 1…
View article: Protein Arginine Methyltransferases as Therapeutic Targets in Hematological Malignancies
Protein Arginine Methyltransferases as Therapeutic Targets in Hematological Malignancies Open
Arginine methylation is a common post-translational modification affecting protein activity and the transcription of target genes when methylation occurs on histone tails. There are nine protein arginine methyltransferases (PRMTs) in mamma…
View article: P451: PRMT2: AN ANTI-INFLAMMATORY EPIGENETIC FACTOR INVOLVED IN ACUTE MYELOID LEUKEMIA AGGRESSIVENESS
P451: PRMT2: AN ANTI-INFLAMMATORY EPIGENETIC FACTOR INVOLVED IN ACUTE MYELOID LEUKEMIA AGGRESSIVENESS Open
Background: Protein Arginine Methyltransferases (PRMTs) are epigenetic factors involved in several cellular processes including regulation of gene expression through methylation of histone tails. Overexpression or overactivity of the two m…
View article: Clinical and Economic Impact of a Multidisciplinary Follow-Up Program in Lymphoma Patients
Clinical and Economic Impact of a Multidisciplinary Follow-Up Program in Lymphoma Patients Open
Objectives: The UMACOACH Lymphoma is a multidisciplinary monitoring program for patients initiating a first highly haematotoxic treatment for Hodgkin or non-Hodgkin lymphoma. Patient follow-up is based on consultation with a pharmacist and…
View article: EARLY POSITRON EMISSION TOMOGRAPHY RESPONSE‐ADAPTED TREATMENT IN LOCALIZED DIFFUSE LARGE B‐CELL LYMPHOMA (AAIPI=0) : RESULTS OF THE PHASE 3 LYSA LNH 09‐1B TRIAL
EARLY POSITRON EMISSION TOMOGRAPHY RESPONSE‐ADAPTED TREATMENT IN LOCALIZED DIFFUSE LARGE B‐CELL LYMPHOMA (AAIPI=0) : RESULTS OF THE PHASE 3 LYSA LNH 09‐1B TRIAL Open
Purpose: R-CHOP is the standard treatment of diffuse large B-cell lymphoma (DLBCL). In localized disease, the FLYER trial (Poeschel et al., Lancet, 2019) showed that 4 cycles of R-CHOP-21 could be as effective as 6 cycles in the younger po…
View article: ORAL PRESENTATIONS
ORAL PRESENTATIONS Open
Chronic lymphocytic leukemia (CLL) represents one of the most active fields of clinical research at the present time. 1,2This short review summarizes some of the basic, translational and clinical research that has led to substantial improv…
View article: Identification of novel, clonally stable, somatic mutations targeting transcription factors PAX5 and NKX2-3, the epigenetic regulator LRIF1, and BRAF in a case of atypical B-cell chronic lymphocytic leukemia harboring a t(14;18)(q32;q21)
Identification of novel, clonally stable, somatic mutations targeting transcription factors PAX5 and NKX2-3, the epigenetic regulator LRIF1, and BRAF in a case of atypical B-cell chronic lymphocytic leukemia harboring a t(14;18)(q32;q21) Open
Diagnosis of B-cell chronic lymphocytic leukemia (B-CLL) is usually straightforward, involving clinical, immunophenotypic (Matutes score), and (immuno)genetic analyses (to refine patient prognosis for treatment). CLL cases with atypical pr…
View article: Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia
Prognostic value of high-sensitivity measurable residual disease assessment after front-line chemoimmunotherapy in chronic lymphocytic leukemia Open
View article: Unusual presentation of blastic plasmacytoid dendritic cell neoplasm: Pitfalls in other hematolymphoid neoplasms
Unusual presentation of blastic plasmacytoid dendritic cell neoplasm: Pitfalls in other hematolymphoid neoplasms Open
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare CD4+/CD56+ hematological malignancy with aggressive clinical course and poor prognosis. Histologically, BPDCN is characterized by a diffuse, monomorphous infiltration of cutane…
View article: High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow
High-fat diet disturbs lipid raft/TGF-β signaling-mediated maintenance of hematopoietic stem cells in mouse bone marrow Open
Despite recent in vivo data demonstrating that high-fat diet (HFD)-induced obesity leads to major perturbations in murine hematopoietic stem cells (HSC), the direct role of a HFD is not yet completely understood. Here, we investigate the d…
View article: Actualités thérapeutiques dans les lymphomes non hodgkiniens et le lymphome de Hodgkin
Actualités thérapeutiques dans les lymphomes non hodgkiniens et le lymphome de Hodgkin Open
View article: HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis
HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis Open
View article: Outcome of chronic lymphocytic leukemia patients who switched from either ibrutinib or idelalisib to alternate kinase inhibitor: A retrospective study of the French innovative leukemia organization (FILO)
Outcome of chronic lymphocytic leukemia patients who switched from either ibrutinib or idelalisib to alternate kinase inhibitor: A retrospective study of the French innovative leukemia organization (FILO) Open
Novel drugs targeting B cell receptor (BCR) signaling, such as ibrutinib and idelalisib, have dramatically changed the outcome of patients with chronic lymphocytic leukemia (CLL), especially those with high-risk features. However, data fro…
View article: Acute lymphoblastic leukemia relapsing after first-line pediatric-inspired therapy: a retrospective GRAALL study
Acute lymphoblastic leukemia relapsing after first-line pediatric-inspired therapy: a retrospective GRAALL study Open
The outcome of adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph− ALL) relapsing after pediatric-inspired front-line therapy is ill known. Here 229 relapsing Ph− ALL younger adults (18–63 years) treated …
View article: CD45, une protéine phosphatase cible importante dans le traitement des leucémies aiguës myéloblastiques
CD45, une protéine phosphatase cible importante dans le traitement des leucémies aiguës myéloblastiques Open
IF 0,671 (2014)
View article: CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts
CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts Open
CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. Exploiting CD45 KO mice and lentiviral shRNA, we prove the crucial role that CD45 plays in acute myeloid…
View article: A randomized phase II trial of azacitidine +/- epoetin- in lower-risk myelodysplastic syndromes resistant to erythropoietic stimulating agents
A randomized phase II trial of azacitidine +/- epoetin- in lower-risk myelodysplastic syndromes resistant to erythropoietic stimulating agents Open
The efficacy of azacitidine in patients with anemia and with lower-risk myelodysplastic syndromes, if relapsing after or resistant to erythropoietic stimulating agents, and the benefit of combining these agents to azacitidine in this setti…
View article: The level of blast CD33 expression positively impacts the effect of gemtuzumab ozogamicin in patients with acute myeloid leukemia
The level of blast CD33 expression positively impacts the effect of gemtuzumab ozogamicin in patients with acute myeloid leukemia Open
International audience
View article: Emergency and elective pulmonary surgical resection in haematological patients with invasive fungal infections: a report of 50 cases in a single centre
Emergency and elective pulmonary surgical resection in haematological patients with invasive fungal infections: a report of 50 cases in a single centre Open