Explanipedia

Rates and predictors of cardiovascular and non‐cardiovascular outcomes in heart failure with preserved ejection fraction Open

Angiza Shahim, Erwan Donal, Camilla Hage, Emmanuel Oger, Gianluigi Savarese , et al. · 2024

Aims The detailed sub‐categories of death and hospitalization, and the impact of comorbidities on cause‐specific outcomes, remain poorly understood in heart failure (HF) with preserved ejection fraction (HFpEF). We sought to evaluate rates…

Ablation of multifocal premature ventricular contractions using automated pace-mapping software Open

Raphaël P. Martins, Karim Bénali, Vincent Galand, Nathalie Béhar, Jean‐Claude Daubert , et al. · 2022

Quantitative morphology-matching software can be used to obtain a detailed map identifying the site of origin of each single PVC, and successful ablation can be performed at these sites, even if activation points cannot be obtained due to …

The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an individual patient data meta‐analysis of COMPANION and CARE‐HF Open

John G.F. Cleland, Michael R. Bristow, Nicholas Freemantle, Brian Olshansky, Daniel Gras , et al. · 2022

Aims Cardiac resynchronization therapy (CRT) reduces morbidity and mortality for patients with heart failure, reduced left ventricular ejection fraction, QRS duration >130 ms and in sinus rhythm. The aim of this study was to identify patie…

Eligibility of patients with heart failure with preserved ejection fraction for sacubitril/valsartan according to the PARAGON‐HF trial Open

Lars H. Lund, Gianluigi Savarese, Ashwin Venkateshvaran, Lina Benson, Anna Lundberg , et al. · 2021

Aims In the heart failure (HF) with preserved ejection fraction (HFpEF) PARAGON‐HF trial, sacubitril/valsartan vs. valsartan improved mortality/morbidity in patients with left ventricular ejection fraction (LVEF) below median (57%). We ass…

2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy Open

Michael Glikson, Jens Cosedis Nielsen, Mads Brix Kronborg, Yoav Michowitz, Angelo Auricchio , et al. · 2021

Pacing is an important part of electrophysiology and of cardiology in general. Whereas some of the situations requiring pacing are clear and have not changed over the years, many others have evolved and have been the subject of extensive r…

Predictors of long‐term outcome in heart failure with preserved ejection fraction: a follow‐up from the KaRen study Open

Angiza Shahim, Marion Hourqueig, Erwan Donal, Emmanuel Oger, Ashwin Venkateshvaran , et al. · 2021

Aims Heart failure (HF) with preserved ejection fraction (HFpEF) has poor long‐term prognosis. We assessed rates and predictors of outcome 10 years after an acute episode of HF. Methods and results The Karolinska‐Rennes (KaRen) study enrol…

Redefining the Classifications of Response to Cardiac Resynchronization Therapy Open

Michael R. Gold, John Rickard, Jean‐Claude Daubert, Patrick Zimmerman, Cecilia Linde · 2021

For both CCS and reverse remodeling, patients who worsen with CRT have a high mortality, although remodeling was the more important endpoint. Patients who stabilize early with CRT have a much better prognosis than previously recognized, su…

Myeloperoxidase and related biomarkers are suggestive footprints of endothelial microvascular inflammation in HFpEF patients Open

Camilla Hage, Erik Michaëlsson, Bengt Kull, Tasso Miliotis, Sara Svedlund , et al. · 2020

Aims In heart failure (HF) with preserved ejection fraction (HFpEF), microvascular inflammation is proposed as an underlying mechanism. Myeloperoxidase (MPO) is associated with vascular dysfunction and prognosis in congestive HF. Methods a…

Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning Open

Åsa K. Hedman, Camilla Hage, Anil Kumar Sharma, M. Julia Brosnan, Leonard Buckbinder , et al. · 2020

Objective Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. We aimed to derive HFpEF phenotype-based groups ('phenogroups') based on clinical and echocardiogram data using machine learning, and to compare …

The challenging right inferior pulmonary vein: A systematic approach for successful cryoballoon ablation Open

Raphaël P. Martins, A. Nicolas, Vincent Galand, C. Pichard, Nathalie Béhar , et al. · 2019

Localization of Residual Conduction Gaps After Wide Antral Circumferential Ablation of Pulmonary Veins Open

Raphaël P. Martins, Vincent Galand, Nathalie Béhar, Jean‐Claude Daubert, Philippe Mabo , et al. · 2019

ST2 in heart failure with preserved and reduced ejection fraction Open

Emil Najjar, Ulrika Ljung Faxén, Camilla Hage, Erwan Donal, Jean‐Claude Daubert , et al. · 2019

In patients with HFpEF compared to HFrEF, crude levels of sST2 were lower but potentially more strongly associated with outcomes. The lower levels of sST2 in HFpEF than in HFrEF may reflect lower degrees of fibrosis, but the potentially st…

Procedural safety and long‐term follow‐up after pacemaker implantation in nonagenarians Open

Duc Anh Dang, Vincent Galand, Aurélie Loirat, Vincent Auffret, Nathalie Béhar , et al. · 2018

Background The rate of pacemaker (PM) implantations is constantly growing. Since life expectancy of the population is projected to increase, a large number of nonagenarian patients will need PM implantation. We aimed at analyzing short‐ an…

Importance of structural heart disease and diastolic dysfunction in heart failure with preserved ejection fraction assessed according to the ESC guidelines - A substudy in the Ka (Karolinska) Ren (Rennes) study Open

Hans Persson, Erwan Donal, Lars H. Lund, Dmitri Matan, Emmanuel Oger , et al. · 2018

Corrigendum to “Changes in natriuretic peptides after acute hospital presentation for heart failure with preserved ejection fraction: A feasible surrogate trial endpoint? A report from the prospective Karen study” [Int. J. Cardiol. 226 (2017) 65–70] Open

Gianluigi Savarese, Erwan Donal, Camilla Hage, Emmanuel Oger, Hans Persson , et al. · 2018

Comparison of Prognostic Usefulness of Serum Insulin-Like Growth Factor-Binding Protein 7 in Patients With Heart Failure and Preserved Versus Reduced Left Ventricular Ejection Fraction Open

Camilla Hage, Mette Bjerre, Jan Frystyk, Harvest F. Gu, Kerstin Brismar , et al. · 2018

Left atrial rather than left ventricular impaired mechanics are associated with the pro‐fibrotic ST2 marker and outcomes in heart failure with preserved ejection fraction Open

Anikó Ilona Nagy, Camilla Hage, Béla Merkely, Erwan Donal, Jean‐Claude Daubert , et al. · 2018

Aims Left ventricular ( LV ) mechanics have been extensively investigated in heart failure with preserved ejection fraction ( HF p EF ) overshadowing for a long time the potential role of left atrium ( LA ) in that setting. Soluble suppres…

Cardiac electronic implantable devices after tricuspid valve surgery Open

Raphaël P. Martins, Vincent Galand, Christophe Leclercq, Jean‐Claude Daubert · 2018

The interaction of sex, height, and QRS duration on the effects of cardiac resynchronization therapy on morbidity and mortality: an individual‐patient data meta‐analysis Open

Cecilia Linde, John G.F. Cleland, Michael R. Gold, Jean‐Claude Daubert, Anthony Tang , et al. · 2018

Aims To explore possible associations that may explain the greater benefit from cardiac resynchronization therapy (CRT) reported amongst women. Methods and results In an individual‐patient data meta‐analysis of five randomized controlled t…

Precision Medicine for Cardiac Resynchronization Open

Michael E. Nassif, Yuanyuan Tang, John G.F. Cleland, William T. Abraham, Cecilia Linde , et al. · 2017

Background: Clinical trials have established the average benefit of cardiac resynchronization therapy (CRT), but estimating benefit for individual patients remains difficult because of the heterogeneity in treatment response. Accordingly, …

P811Right versus left durable pulmonary vein isolation using the first and second generation cryoballoons: comparative results from a French multicenter study Open

RP Martins, Vincent Galand, Olivier Césari, Antoine Milhem, Nathalie Béhar , et al. · 2017

Background: Pulmonary veins isolation (PVI) using the second-generation cryoballoon (CB2) is associated with improved outcomes compared to first generation (CB1).Little is known about the mechanisms underlying such improvement and whether …

The second generation cryoballoon has improved durable isolation of left but not right pulmonary veins: new insights from a multicentre study Open

Raphaël P. Martins, Vincent Galand, Olivier Césari, Antoine Milhem, Nathalie Béhar , et al. · 2017

Fewer reconnection gaps are observed during redo ablations of paroxysmal AF in patients primarily ablated with CB2. This difference is driven by less reconnection gaps observed in both left PVs, while no difference was observed for right P…

Pilot study using 3D–longitudinal strain computation in a multi-parametric approach for best selecting responders to cardiac resynchronization therapy Open

Maxime Fournet, Anne Bernard, Sylvestre Maréchaux, Elena Galli, Raphaël P. Martins , et al. · 2017

Peritoneal migration of an epicardial pacemaker Open

Vincent Galand, Jean Marc Schleich, Baptiste Polin, Jean‐Claude Daubert, Christophe Leclercq , et al. · 2017

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Predictors of short‐term clinical response to cardiac resynchronization therapy Open

Cecilia Linde, William T. Abraham, Michael R. Gold, Jean‐Claude Daubert, Anthony Tang , et al. · 2017

Aims Cardiac resynchronization therapy ( CRT ) reduces morbidity and mortality in patients with symptomatic heart failure and QRS prolongation but there is uncertainty about which patient characteristics predict short‐term clinical respons…

Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection Fraction Open

Camilla Hage, Erik Michaëlsson, Cecilia Linde, Erwan Donal, Jean‐Claude Daubert , et al. · 2017

Background— Underlying mechanisms in heart failure (HF) with preserved ejection fraction remain unknown. We investigated cardiovascular plasma biomarkers in HF with preserved ejection fraction and their correlation to diastolic dysfunction…

Defining nonvalvular atrial fibrillation: A quest for clarification Open

Raphaël P. Martins, Vincent Galand, E.R.P. Colette, Nathalie Béhar, Dominique Pavin , et al. · 2016

Atrial Fibrillation in a Dual‐Chamber ICD Recipient with Activation of the Ventricular Intrinsic Preference Algorithm: What Is the Mechanism? Open

Raphaël P. Martins, Vincent Galand, Nathalie Béhar, Philippe Mabo, Jean‐Claude Daubert , et al. · 2016

Characteristics and prognosis of pneumococcal endocarditis: a case–control study Open

Myriam Daudin, Pierre Tattevin, Bernard Lelong, Erwan Flécher, Sylvain Lavoué , et al. · 2016

Copeptin in patients with heart failure and preserved ejection fraction: a report from the prospective KaRen-study Open

Camilla Hage, Lars H. Lund, Erwan Donal, Jean‐Claude Daubert, Cecilia Linde , et al. · 2015

Introduction Underlying mechanisms of heart failure (HF) with preserved ejection fraction (HFPEF) remain unknown. We explored copeptin, a biomarker of the arginine vasopressin system, hypothesising that copeptin in HFPEF is elevated, assoc…

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