Jean Claude Semuto Ngabonziza
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View article: Multicenter field evaluation of Xpert MTB/XDR in Sub-Saharan Africa
Multicenter field evaluation of Xpert MTB/XDR in Sub-Saharan Africa Open
The WHO-endorsed Xpert MTB/XDR assay provides a rapid method to detect resistance to isoniazid, fluoroquinolones, injectables aminoglycosides and ethionamide yet evaluation of its performance, particularly in endemic settings, remains limi…
View article: Effectiveness of a digital clinical decision support algorithm for guiding antibiotic prescribing in pediatric outpatient care in Rwanda: A pragmatic cluster non-randomized controlled trial
Effectiveness of a digital clinical decision support algorithm for guiding antibiotic prescribing in pediatric outpatient care in Rwanda: A pragmatic cluster non-randomized controlled trial Open
Background Poor adherence to clinical guidelines and diagnostic uncertainty are key contributors to antibiotic overprescription, accelerating antimicrobial resistance—a major global health threat. We developed ePOCT+, a digital clinical de…
View article: Provider's and stakeholders' experiences with and perceptions of the benefits and challenges of delivering care for noncommunicable diseases within HIV care services in Rwanda
Provider's and stakeholders' experiences with and perceptions of the benefits and challenges of delivering care for noncommunicable diseases within HIV care services in Rwanda Open
Background The growing burden of noncommunicable diseases (NCDs) among people living with HIV (PLHIV) in sub-Saharan Africa, including Rwanda, presents a complex healthcare challenge. Delivering NCD care within HIV services is crucial for …
View article: Enhancing Global Health Security in Sub-Saharan Africa: The case for integrated One Health surveillance against zoonotic diseases and environmental threats
Enhancing Global Health Security in Sub-Saharan Africa: The case for integrated One Health surveillance against zoonotic diseases and environmental threats Open
View article: Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo
Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo Open
The emergence of resistance is of great concern in the control of TB, especially to the new and repurposed drugs needed for the treatment of rifampicin resistance. We report a patient from South Kivu in the Eastern Democratic Republic of t…
View article: A Case Report of Venous Ulcer Mimicking Cutaneous Leishmaniasis
A Case Report of Venous Ulcer Mimicking Cutaneous Leishmaniasis Open
Venous ulcers can sometimes be difficult to diagnose accurately because they can resemble other skin lesions such as cutaneous leishmaniasis. Here, we present a patient with a venous ulcer that mimics cutaneous leishmaniasis and mycetoma l…
View article: Kinetics of hematological and biochemical biomarkers are key tools for monitoring disease progression in Marburg virus-infected patients in Rwanda
Kinetics of hematological and biochemical biomarkers are key tools for monitoring disease progression in Marburg virus-infected patients in Rwanda Open
Marburg Virus Disease (MVD) is a severe disease with a fatality rate of up to 90%. Limited studies have suggested hematological and biochemical biomarkers for managing MVD, but data on key markers correlated with MVD development are scarce…
View article: Rwandan National Reference Laboratory Championing Biosafety and Biosecurity While Leading the Response to Marburg Virus Outbreak in the Country
Rwandan National Reference Laboratory Championing Biosafety and Biosecurity While Leading the Response to Marburg Virus Outbreak in the Country Open
The Marburg virus (MARV) is an extremely contagious zoonotic virus that leads to severe hemorrhagic fever in humans, with a fatality rate as high as 90%. It is known for causing nosocomial outbreaks in hospitals and laboratories globally. …
View article: Perceptions about COVID-19 vaccine among healthcare workers in Rwanda: A mixed-methods study
Perceptions about COVID-19 vaccine among healthcare workers in Rwanda: A mixed-methods study Open
This study reveals discrepancies in HCWs vaccine confidence in Rwanda, highlighting the need for targeted educational interventions to strengthen national COVID-19 response efforts.
View article: Paucibacillary Tuberculosis Drives the Low Positive Predictive Value of Xpert MTB/RIF Ultra for Rifampicin Resistance Detection in Low-Prevalence Settings
Paucibacillary Tuberculosis Drives the Low Positive Predictive Value of Xpert MTB/RIF Ultra for Rifampicin Resistance Detection in Low-Prevalence Settings Open
Background Xpert MTB/RIF Ultra (Ultra) aimed to improve the specificity in identifying rifampicin-resistant tuberculosis (RR-TB), compared to Xpert MTB/RIF. Methods In a nationwide study in Rwanda, patients diagnosed with RR-TB by Ultra be…
View article: The Mpox Response Among Key Populations at High Risk of or Living with HIV in Rwanda: Leveraging the Successful National HIV Control Program for More Impactful Interventions
The Mpox Response Among Key Populations at High Risk of or Living with HIV in Rwanda: Leveraging the Successful National HIV Control Program for More Impactful Interventions Open
Mpox, an emerging zoonotic infectious disease, presents a significant public health threat, especially among high-risk groups like female sex workers and men who have sex with men. This commentary reviews and summarizes Rwanda’s response t…
View article: Half-decade of scaling up malaria control: malaria trends and impact of interventions from 2018 to 2023 in Rwanda
Half-decade of scaling up malaria control: malaria trends and impact of interventions from 2018 to 2023 in Rwanda Open
View article: Natural language processing to evaluate texting conversations between patients and healthcare providers during COVID-19 Home-Based Care in Rwanda at scale
Natural language processing to evaluate texting conversations between patients and healthcare providers during COVID-19 Home-Based Care in Rwanda at scale Open
Community isolation of patients with communicable infectious diseases limits spread of pathogens but our understanding of isolated patients’ needs and challenges is incomplete. Rwanda deployed a digital health service nationally to assist …
View article: Rift Valley Fever in Rwanda Is Urging for Enhancing Global Health Security Through Multisectoral One Health Strategy
Rift Valley Fever in Rwanda Is Urging for Enhancing Global Health Security Through Multisectoral One Health Strategy Open
Rift Valley fever (RVF) is a devastating zoonotic mosquito-borne viral hemorrhagic fever disease that threats human and animal health and biodiversity in Africa, including in Rwanda. RVF is increasingly outbreaking in Africa, leading to de…
View article: Kinetics of Hematological and Biochemical Biomarkers Predict Disease Outcome in Marburg Virus-Infected Patients in Rwanda
Kinetics of Hematological and Biochemical Biomarkers Predict Disease Outcome in Marburg Virus-Infected Patients in Rwanda Open
View article: Developing and Implementing Community Health Workers-Led Digital Integrated Diseases Screening System to Provide Healthcare for Patients at Community Level in Rwanda
Developing and Implementing Community Health Workers-Led Digital Integrated Diseases Screening System to Provide Healthcare for Patients at Community Level in Rwanda Open
View article: Genomic and transmission dynamics of the 2024 Marburg virus outbreak in Rwanda
Genomic and transmission dynamics of the 2024 Marburg virus outbreak in Rwanda Open
View article: Evidence-Based Guidance for One Health Preparedness, Prevention, and Response Strategies to Marburg Virus Disease Outbreaks
Evidence-Based Guidance for One Health Preparedness, Prevention, and Response Strategies to Marburg Virus Disease Outbreaks Open
Objectives: Marburg virus disease (MVD) is on the WHO list for pandemic-prone pathogens. The current outbreak in Rwanda provides an opportunity to map outbreaks and generate information to inform policymaking, resource mobilization, and gu…
View article: Genomic characterization uncovers transmission dynamics of Marburg Virus in Rwanda following a single zoonotic spillover event
Genomic characterization uncovers transmission dynamics of Marburg Virus in Rwanda following a single zoonotic spillover event Open
The ongoing outbreak of Marburg virus disease (MVD) in Rwanda marks the third largest historically, though it has exhibited the lowest fatality rate. Genomic analysis has identified a lineage with limited internal diversity most closely re…
View article: A case report of venous ulcer mimicking cutaneous leishmaniasis
A case report of venous ulcer mimicking cutaneous leishmaniasis Open
View article: Prescription Practices and Usage of Antimicrobials in a Tertiary Teaching Hospital in Rwanda: A Call for Antimicrobial Stewardship
Prescription Practices and Usage of Antimicrobials in a Tertiary Teaching Hospital in Rwanda: A Call for Antimicrobial Stewardship Open
Background: Antimicrobial resistance (AMR) is a global problem that results in high morbidity and mortality, particularly in low- and middle-income countries. Inappropriate use of antimicrobials is a major driver of AMR. This study aimed t…
View article: Emerging Threat of Marburg Virus Disease: Epidemiology, Clinical Management, and the One Health Strategy for Prevention and Control
Emerging Threat of Marburg Virus Disease: Epidemiology, Clinical Management, and the One Health Strategy for Prevention and Control Open
Objectives: Marburg virus disease (MVD), caused by the Marburg virus, is a severe zoonotic viral hemorrhagic fever with high mortality that threats the Global Health Security. Marburg virus is on the WHO list for the next pandemic-prone pa…
View article: Diversity and Distribution of Fungal Infections in Rwanda: High Risk and Gaps in Knowledge, Policy, and Interventions
Diversity and Distribution of Fungal Infections in Rwanda: High Risk and Gaps in Knowledge, Policy, and Interventions Open
Fungal infections (FIs) are spreading globally, raising a significant public health concern. However, its documentation remains sparse in Africa, particularly in Rwanda. This report provides a comprehensive review of FIs in Rwanda based on…
View article: Natural language processing to evaluate texting conversations between patients and healthcare providers during COVID-19 Home-Based Care in Rwanda at scale
Natural language processing to evaluate texting conversations between patients and healthcare providers during COVID-19 Home-Based Care in Rwanda at scale Open
Isolation of patients with communicable infectious diseases limits spread of pathogens but can be difficult to manage outside hospitals. Rwanda deployed a digital health service nationally to assist public health clinicians to remotely mon…
View article: Prescription Practices and Usage of Antimicrobials in a Tertiary Teaching Hospital in Rwanda: A Call for Antimicrobial Stewardship
Prescription Practices and Usage of Antimicrobials in a Tertiary Teaching Hospital in Rwanda: A Call for Antimicrobial Stewardship Open
Antimicrobial resistance (AMR) is a global threat associated with high morbidity and mortality, particularly in low- and middle-income countries. Inappropriate use of antimicrobials is one of the major drivers of the AMR pandemic. This stu…
View article: Uncovering the Diversity and Distribution of Fungal Infections in Rwanda: Assessing Risks and Documenting Knowledge and Policy Gaps
Uncovering the Diversity and Distribution of Fungal Infections in Rwanda: Assessing Risks and Documenting Knowledge and Policy Gaps Open
Fungal infections (FIs) are spreading globally causing a significant public health concern. However, its documentation remains sparse in Africa, particularly in Rwanda. This literature review, aims to assess the risk and document current g…
View article: Safety of high-dose amikacin in the first week of all-oral rifampicin-resistant tuberculosis treatment for the prevention of acquired resistance (STAKE): protocol for a single-arm clinical trial
Safety of high-dose amikacin in the first week of all-oral rifampicin-resistant tuberculosis treatment for the prevention of acquired resistance (STAKE): protocol for a single-arm clinical trial Open
Introduction An effective rifampicin-resistant tuberculosis (RR-TB) treatment regimen should include prevention of resistance amplification. While bedaquiline (BDQ) has been recommended in all-oral RR-TB treatment regimen since 2019, resis…
View article: Assessing the adoption and utilization of the Rwanda COVID-19 data analytics system: a mixed methods approach
Assessing the adoption and utilization of the Rwanda COVID-19 data analytics system: a mixed methods approach Open
Introduction: Rwanda has been widely lauded for its exceptional response to the COVID-19 pandemic. However, although Rwanda established a national system for COVID-19 testing and vaccination data, concerns have been raised about data fragm…
View article: Shaping the future of global access to safe, effective, appropriate and quality health products
Shaping the future of global access to safe, effective, appropriate and quality health products Open
View article: High Rates of False Rifampicin Resistance in Paucibacillary Tuberculosis Patients by Xpert MTB/RIF Ultra
High Rates of False Rifampicin Resistance in Paucibacillary Tuberculosis Patients by Xpert MTB/RIF Ultra Open