Jean Eberlein
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View article: Apelin signaling acts as a molecular switch between endothelial and hematopoietic stem cell fates
Apelin signaling acts as a molecular switch between endothelial and hematopoietic stem cell fates Open
Hematopoietic stem and progenitor cells (HSPCs) emerge from arterial endothelial cells (ECs) through a process termed endothelial-to-hematopoietic-transition (EHT), a process induced by paracrine signals and driven by a transcriptional cas…
View article: Neural progenitor–derived Apelin controls tip cell behavior and vascular patterning
Neural progenitor–derived Apelin controls tip cell behavior and vascular patterning Open
During angiogenesis, vascular tip cells guide nascent vascular sprouts to form a vascular network. Apelin, an agonist of the G protein–coupled receptor Aplnr, is enriched in vascular tip cells, and it is hypothesized that vascular-derived …
View article: Molecular and Cellular Mechanisms of Vascular Development in Zebrafish
Molecular and Cellular Mechanisms of Vascular Development in Zebrafish Open
The establishment of a functional cardiovascular system is crucial for the development of all vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular diseases, which are among the top 10 causes of death …
View article: Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state
Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state Open
To form new blood vessels (angiogenesis), endothelial cells (ECs) must be activated and acquire highly migratory and proliferative phenotypes. However, the molecular mechanisms that govern these processes are incompletely understood. Here,…