Jean Isnard
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View article: Seizure-related biomarkers of sudden unexpected death in epilepsy (SUDEP) in drug-resistant focal epilepsy (REPO2MSE): a prospective, multicentre case–control study
Seizure-related biomarkers of sudden unexpected death in epilepsy (SUDEP) in drug-resistant focal epilepsy (REPO2MSE): a prospective, multicentre case–control study Open
French Ministry of Health (Programme Hospitalier de Recherche Clinique National 2009).
View article: High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex
High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex Open
The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric diso…
View article: Insights from stereoelectroencephalography in <scp> <i>KCNT1</i> </scp> ‐related focal epilepsy suggest a multifocal and migrating epileptogenic network
Insights from stereoelectroencephalography in <span> <i>KCNT1</i> </span> ‐related focal epilepsy suggest a multifocal and migrating epileptogenic network Open
The most characteristic syndrome related to KCNT1 is epilepsy of infancy with migrating focal seizures. Unifocal epilepsies have also been reported, the most common being sleep‐related hypermotor epilepsy (SHE) of frontal origin. Only 10 c…
View article: Visceral and emotional responses to direct electrical stimulations of the cortex
Visceral and emotional responses to direct electrical stimulations of the cortex Open
Objective Visceral sensations are bodily symptoms which are component manifestations of emotions frequently reported during epileptic seizures. Nowadays, the underlying mechanism and location of brain areas involved in the processing of th…
View article: Predictors of outcomes after surgery for medically intractable insular epilepsy: A systematic review and individual participant data <scp>meta‐analysis</scp>
Predictors of outcomes after surgery for medically intractable insular epilepsy: A systematic review and individual participant data <span>meta‐analysis</span> Open
Insular epilepsy (IE) is an increasingly recognized cause of drug‐resistant epilepsy amenable to surgery. However, concerns of suboptimal seizure control and permanent neurological morbidity hamper widespread adoption of surgery for IE. We…
View article: Epileptic spasms are associated with increased stereo‐electroencephalography derived functional connectivity in tuberous sclerosis complex
Epileptic spasms are associated with increased stereo‐electroencephalography derived functional connectivity in tuberous sclerosis complex Open
Objective Epileptic spasms (ES) are common in tuberous sclerosis complex (TSC). However, the underlying network alterations and relationship with epileptogenic tubers are poorly understood. We examined interictal functional connectivity (F…
View article: Peri‐ictal hypoxemia during temporal lobe seizures: A <scp>SEEG</scp> study
Peri‐ictal hypoxemia during temporal lobe seizures: A <span>SEEG</span> study Open
Focal seizures originating from the temporal lobe are commonly associated with peri‐ictal hypoxemia (PIH). During the course of temporal lobe seizures, epileptic discharges often not only spread within various parts of the temporal lobe bu…
View article: Surgical outcome of temporal plus epilepsy is improved by multilobar resection
Surgical outcome of temporal plus epilepsy is improved by multilobar resection Open
Objective Temporal plus epilepsy (TPE) represents a rare type of epilepsy characterized by a complex epileptogenic zone including the temporal lobe and the close neighboring structures. We investigated whether the complete resection of tem…
View article: A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials
A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials Open
Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials at distant sites because of white matter connectivity. Cortico-c…
View article: The Role of Hybrid FDG-PET/MRI on Decision-Making in Presurgical Evaluation of Drug-Resistant Epilepsy.
The Role of Hybrid FDG-PET/MRI on Decision-Making in Presurgical Evaluation of Drug-Resistant Epilepsy. Open
Background: When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60-90 % to 20-65 %). Hybrid FDG-PET/MRI may provide additional information …
View article: Epileptogenicity in tuberous sclerosis complex: A stereoelectroencephalographic study
Epileptogenicity in tuberous sclerosis complex: A stereoelectroencephalographic study Open
Objective In tuberous sclerosis complex (TSC)‐associated drug‐resistant epilepsy, the optimal invasive electroencephalographic (EEG) and operative approach remains unclear. We examined the role of stereo‐EEG in TSC and used stereo‐EEG data…
View article: Slow cortico-cortical connectivity (2-5Hz) is a new robust signature of conscious states
Slow cortico-cortical connectivity (2-5Hz) is a new robust signature of conscious states Open
While long-range cortico-cortical functional connectivity has been reported by several studies as a necessary condition of conscious state, precise empirical evidence is still scarce. In the present work we provide such a direct and conclu…
View article: How the insula speaks to the heart: Cardiac responses to insular stimulation in humans
How the insula speaks to the heart: Cardiac responses to insular stimulation in humans Open
Despite numerous studies suggesting the role of insular cortex in the control of autonomic activity, the exact location of cardiac motor regions remains controversial. We provide here a functional mapping of autonomic cardiac responses to …
View article: The Insula and Its Epilepsies
The Insula and Its Epilepsies Open
Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semio…
View article: BLAST : a short computerized test to measure the ability to stay on task. Normative behavioral data and detailed cortical dynamics.
BLAST : a short computerized test to measure the ability to stay on task. Normative behavioral data and detailed cortical dynamics. Open
This article provides an exhaustive description of a new short computerized test to assess on a second-to-second basis the ability of individuals to stay on task, that is, to apply selectively and repeatedly task-relevant cognitive process…
View article: Stereo‐electroencephalography‐guided radiofrequency thermocoagulation in patients with focal epilepsy: A systematic review and meta‐analysis
Stereo‐electroencephalography‐guided radiofrequency thermocoagulation in patients with focal epilepsy: A systematic review and meta‐analysis Open
Summary Objective Despite the increasing number of studies reporting results of stereo‐electroencephalography (SEEG)–guided radiofrequency‐thermocoagulation ( SEEG ‐guided RF ‐ TC ) in the treatment of patients with drug‐resistant focal ep…
View article: Stereo electroencephalography–guided radiofrequency thermocoagulation (SEEG‐guided RF‐TC) in drug‐resistant focal epilepsy: Results from a 10‐year experience
Stereo electroencephalography–guided radiofrequency thermocoagulation (SEEG‐guided RF‐TC) in drug‐resistant focal epilepsy: Results from a 10‐year experience Open
Summary Objective Stereo electroencephalography ( SEEG )–guided radiofrequency thermocoagulation ( SEEG ‐guided RF ‐ TC ) has been proposed since 2004 as a possible treatment of some focal drug‐resistant epilepsy. The aim of this study is …