Jean X. Jiang
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View article: Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1 Open
Microglia are brain-resident macrophages critical for cerebral development, function, and homeostasis. During development, yolk sac-derived microglial progenitor cells colonize and populate the brain following a well-defined spatiotemporal…
View article: Correction: Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter
Correction: Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter Open
[This corrects the article DOI: 10.1371/journal.pone.0056792.].
View article: Mechano-activated connexin hemichannels mediate intercellular glutathione transport and support lens redox homeostasis
Mechano-activated connexin hemichannels mediate intercellular glutathione transport and support lens redox homeostasis Open
Redox homeostasis and transparency in the ocular lens are closely associated with the distribution of the antioxidant reduced glutathione (GSH). While the synthesis and recycling of GSH have been well characterized, the mechanisms governin…
View article: How cell crowding causes cancer cells to spread
How cell crowding causes cancer cells to spread Open
Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread.
View article: Osteocyte connexin hemichannels and prostaglandin E <sub>2</sub> release dictate bone marrow mesenchymal stromal cell commitment
Osteocyte connexin hemichannels and prostaglandin E <sub>2</sub> release dictate bone marrow mesenchymal stromal cell commitment Open
Bone is a dynamic organ constantly undergoing remodeling with both bone formation and resorption. Bone formation is mediated by osteoblasts originating from the differentiation of bone marrow (BM) mesenchymal stem and progenitor cells (BM-…
View article: Extracellular vesicles released by glioblastoma cancer cells drive tumor invasiveness via Connexin-43 gap junctions
Extracellular vesicles released by glioblastoma cancer cells drive tumor invasiveness via Connexin-43 gap junctions Open
Background Although invasiveness is one of the major determinants of the poor glioblastoma (GBM) outcome, the mechanisms of GBM invasion are only partially understood. Among the intrinsic and environmental processes promoting cell-to-cell …
View article: Activation of connexin hemichannels enhances mechanosensitivity and anabolism in disused and aged bone
Activation of connexin hemichannels enhances mechanosensitivity and anabolism in disused and aged bone Open
Mechanical loading, essential for bone health, promotes bone formation and remodeling. However, the positive response diminishes in cases of disuse and aging, leading to bone loss and an increased fracture risk. This study demonstrates tha…
View article: Dermatopontin-expressing fibroblasts mediate an essential skin macrophage niche
Dermatopontin-expressing fibroblasts mediate an essential skin macrophage niche Open
Fibroblasts are present in all tissues and are crucial for maintaining tissue homeostasis. We previously identified fibroblasts marked by Dermatopontin ( Dpt ) but their role in supporting macrophage homeostasis remains unclear. Here, we g…
View article: Connexin 43 hemichannels and related diseases
Connexin 43 hemichannels and related diseases Open
Connexin 43 (Cx43) protein forms hemichannels (connexons) and gap junctions, with hemichannels consisting of six Cx43 molecules and gap junctions formed by two hemichannels. While gap junctions are prevalent in organs like the heart and li…
View article: Basophils drive the resolution and promote wound healing in adult and aged mice
Basophils drive the resolution and promote wound healing in adult and aged mice Open
An active resolution is critical to control the duration of inflammation and limit its pathological consequences. Defects in resolution during wound healing allow the emergence of chronic wounds, a common complication in the elderly. Here,…
View article: Connexin hemichannels drive lactation-induced osteocyte acidification and perilacunar-canalicular remodeling
Connexin hemichannels drive lactation-induced osteocyte acidification and perilacunar-canalicular remodeling Open
The maternal skeleton experiences significant bone loss during lactation, followed by rapid restoration post weaning. Parathyroid-related protein (PTHrP)-induced acidification of the perilacunar matrix by osteocytes is crucial in this proc…
View article: Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS
Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS Open
The extracellular superoxide dismutases (ecSODs) secreted by Microplitis bicoloratus reduce the reactive oxygen species (ROS) stimulated by the Microplitis bicoloratus bracovirus. Here, we demonstrate that the bacterial transferase hexapep…
View article: Gap Junctions or Hemichannel-Dependent and Independent Roles of Connexins in Fibrosis, Epithelial–Mesenchymal Transitions, and Wound Healing
Gap Junctions or Hemichannel-Dependent and Independent Roles of Connexins in Fibrosis, Epithelial–Mesenchymal Transitions, and Wound Healing Open
Fibrosis initially appears as a normal response to damage, where activated fibroblasts produce large amounts of the extracellular matrix (ECM) during the wound healing process to assist in the repair of injured tissue. However, the excessi…
View article: DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages
DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages Open
Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or through self-renewal. While the presence of a nurturing niche is likely crucial to support the survival and function of self-renewing RMs, evidence regardi…
View article: Protocol for altering connexin hemichannel function in primary chicken lens fiber cells using high-titer retroviral RCAS(A) infection
Protocol for altering connexin hemichannel function in primary chicken lens fiber cells using high-titer retroviral RCAS(A) infection Open
Connexins (Cxs) play a crucial role in maintaining lens transparency. Here, we present a protocol for altering Cx hemichannel (HC) function in primary chicken lens fiber cells using high-titer retroviral replication competent avian sarcoma…
View article: The Role of Gap Junctions Dysfunction in the Development of Cataracts: From Loss of Cell-to-Cell Transfer to Blurred Vision—Review
The Role of Gap Junctions Dysfunction in the Development of Cataracts: From Loss of Cell-to-Cell Transfer to Blurred Vision—Review Open
Mutations of lens connexins are linked to congenital cataracts. However, the role of connexin mutations in the development of age-related lens opacification remains largely unknown. Here, we present a focused review of the literature on le…
View article: Autocrine Factors Produced by Mesenchymal Stem Cells in Response to Cell–Cell Contact Inhibition Have Anti-Tumor Properties
Autocrine Factors Produced by Mesenchymal Stem Cells in Response to Cell–Cell Contact Inhibition Have Anti-Tumor Properties Open
Recently, mesenchymal stem cell (MSC) therapies have been questioned as MSCs are capable of both promoting and inhibiting tumorigenesis. Both MSCs and tumor cells replicate to increase their population size; however, MSCs, but not tumor ce…
View article: Connexin 43 hemichannels and prostaglandin E2 release in anabolic function of the skeletal tissue to mechanical stimulation
Connexin 43 hemichannels and prostaglandin E2 release in anabolic function of the skeletal tissue to mechanical stimulation Open
Bone adapts to changes in the physical environment by modulating remodeling through bone resorption and formation to maintain optimal bone mass. As the most abundant connexin subtype in bone tissue, connexin 43 (Cx43)-forming hemichannels …
View article: Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone
Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone Open
Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize Csf1 to stimulate osteoclastogenesis. We rece…