Jean Legault
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View article: Conventional and industrial by-product fertilization do not induce greenhouse gas emissions in sandy soils under wild lowbush blueberry cropping in eastern Canada
Conventional and industrial by-product fertilization do not induce greenhouse gas emissions in sandy soils under wild lowbush blueberry cropping in eastern Canada Open
View article: Toward Long-Acting Psoriasis Therapy with Phloretin-Loaded Microneedle Patches: Insights from <i>In Vitro</i> Patient-Derived Skin Models
Toward Long-Acting Psoriasis Therapy with Phloretin-Loaded Microneedle Patches: Insights from <i>In Vitro</i> Patient-Derived Skin Models Open
Plaque psoriasis is a chronic inflammatory skin disorder characterized by excessive T lymphocyte infiltration and keratinocyte hyperproliferation, resulting in epidermal thickening. Current treatments often require lifelong administration …
View article: Alkaloids of Delphinium Species Distributed in Georgia and Their Cytotoxic Activity
Alkaloids of Delphinium Species Distributed in Georgia and Their Cytotoxic Activity Open
View article: Conventional and industrial by-product fertilization do not induce greenhouse gas emissions in sandy soils under wild lowbush blueberry cropping in eastern Canada
Conventional and industrial by-product fertilization do not induce greenhouse gas emissions in sandy soils under wild lowbush blueberry cropping in eastern Canada Open
View article: Microneedles with Implantable Tip‐Accumulated Therapeutics for the Long‐Term Management of Psoriasis
Microneedles with Implantable Tip‐Accumulated Therapeutics for the Long‐Term Management of Psoriasis Open
Methotrexate is successfully used as the gold standard for managing moderate‐to‐severe psoriasis. However, the low bioavailability and short half‐life of the oral pills and the invasiveness of the parenteral injections make these suboptima…
View article: Synthesis and pharmacological evaluation of nature-inspired phenacyl glycosides
Synthesis and pharmacological evaluation of nature-inspired phenacyl glycosides Open
View article: Antiproliferative and Anti-Inflammatory Effects of the Polyphenols Phloretin and Balsacone C in a Coculture of T Cells and Psoriatic Keratinocytes
Antiproliferative and Anti-Inflammatory Effects of the Polyphenols Phloretin and Balsacone C in a Coculture of T Cells and Psoriatic Keratinocytes Open
Plaque psoriasis is a chronic inflammatory skin disease causing red inflamed lesions covered by scales. Leukocytes, including dendritic cells and T cells, participate in the inflammation of the skin by producing multiple cytokines, thus co…
View article: Pharmacognostical study of aerial Parts of Thymus collinus Bieb. growing in Georgia
Pharmacognostical study of aerial Parts of Thymus collinus Bieb. growing in Georgia Open
A study of the chemical composition of the essential oil obtained from the aerial parts of Thymus collinus Bieb., collected in Kvemo Kartli floristic area (Georgia), endemic to caucasus, was carried out. The percentage of terpenic componen…
View article: Alkaloids of ATROPA CAUCASICA KREYER and Their Biological Activity
Alkaloids of ATROPA CAUCASICA KREYER and Their Biological Activity Open
View article: Synthesis and Pharmacological Evaluation of Nature-Inspired Phenacyl Glycosides
Synthesis and Pharmacological Evaluation of Nature-Inspired Phenacyl Glycosides Open
View article: Synthesis and Cytotoxicity Evaluation of D- and L-Sugar-Containing Mono- and Bidesmosidic Ursane-Type Saponins
Synthesis and Cytotoxicity Evaluation of D- and L-Sugar-Containing Mono- and Bidesmosidic Ursane-Type Saponins Open
View article: Chemical Composition and Biological Activity of Aerial Parts of Thymus collinus Bieb. Growing in Georgia
Chemical Composition and Biological Activity of Aerial Parts of Thymus collinus Bieb. Growing in Georgia Open
Background: Thymus L is one of the most important genera of the Lamiaceae family.In traditional medicine, leaves and flowers of Thymus species are used as a tonic, antiseptic, analgesic, anti-inflammatory, and antitussive.Complex medicines…
View article: Synthesis and Cytotoxicity of Monomethylated Betulinic Acid 3-<i>O</i>-α-<scp>l</scp>-Rhamnopyranosides
Synthesis and Cytotoxicity of Monomethylated Betulinic Acid 3-<i>O</i>-α-<span>l</span>-Rhamnopyranosides Open
Three original derivatives of the cytotoxic betulinic acid 3-O-α-l-rhamnopyranoside featuring a monomethylated rhamnoside residue were synthesized. An improved catalytic procedure was involved to functionalize the O-3 positio…
View article: STUDY OF THE CYTOTOXIC ACTIVITY OF ALKALOID- CONTAINING FRACTIONS ISOLATED FROM CERTAIN PLANT SPECIES GROWING AND INTRODUCED IN GEORGIA
STUDY OF THE CYTOTOXIC ACTIVITY OF ALKALOID- CONTAINING FRACTIONS ISOLATED FROM CERTAIN PLANT SPECIES GROWING AND INTRODUCED IN GEORGIA Open
The objects of the study were Ephedra procera Fisch (Fam. Ephedraceae), Taxus baccata L. (Fam. Taxaceae) and Mahonia aquifolium (Pursh) Nutt (Fam. Berberidaceae) growing or introduced in Georgia. Biologically active alkaloid-containing sub…
View article: Antioxidant, anti-inflammatory and anticancer activities of Tunisian halophyte Suaeda mollis
Antioxidant, anti-inflammatory and anticancer activities of Tunisian halophyte Suaeda mollis Open
The aim of this study was to investigate the antioxidant, anti-inflammatory, and anticancer properties of Tunisian Suaeda mollis specie after fractionation by increasing polarity of several extracts (Hexane, Dichloromerthane, Methanol and …
View article: GREEN SYNTHESIS OS SILVER NANOPARTICLES USING METHANOLIC EXTRACTS OF GENTIANA SEPTEMFIDA, ERYSIMUM CONTRACTUM AND CHELIDONIUM MAJUS AND EVALUATION OF ANTIBACTERIAL, ANTIFUNGAL AND CYTOTOXIC ACTIVITIES OF OBTAINED AGNPS
GREEN SYNTHESIS OS SILVER NANOPARTICLES USING METHANOLIC EXTRACTS OF GENTIANA SEPTEMFIDA, ERYSIMUM CONTRACTUM AND CHELIDONIUM MAJUS AND EVALUATION OF ANTIBACTERIAL, ANTIFUNGAL AND CYTOTOXIC ACTIVITIES OF OBTAINED AGNPS Open
Biosynthesis of metallic nanoparticles is simple, effective, eco-friendly and inexpensive way. It is a non-toxic method. Biosynthesized nanoparticles are primarily biocompatible and can be used in biomedical applications. Silver nanopartic…
View article: Powerful anti-inflammatory, anti-Herpes and anticancer capacities of Thymelaea microphylla L. and TLC phenolic identification
Powerful anti-inflammatory, anti-Herpes and anticancer capacities of Thymelaea microphylla L. and TLC phenolic identification Open
Thymelaea microphylla is an edible and medicinal species that exhibits high antioxidant activity and phenolic content. Moreover, four fractions (hexane, dichloromethane, methanol and water) were tested towards their ex-vivo antioxidant, an…
View article: Effect of the Chromone Core Substitution of Dirchromone on the Resultant Biological Activities
Effect of the Chromone Core Substitution of Dirchromone on the Resultant Biological Activities Open
Dirchromone is a bioactive vinyl sulfoxide-bearing chromone first isolated from the shrub Dirca palustris. Altogether, 32 of its derivatives were prepared to assess the effect of substitution of its chromone core upon activities aga…
View article: Bio-Guided Fractionation of Retama raetam (Forssk.) Webb & Berthel Polar Extracts
Bio-Guided Fractionation of Retama raetam (Forssk.) Webb & Berthel Polar Extracts Open
The fractionation of the methanolic extract (MeOH-E) of Retama raetam (Forssk.) Webb & Berthel and further analysis by thin layer chromatography resulted in four fractions (F1, F2, F3 and F4) that, in parallel with the MeOH-E, were screene…
View article: Antioxidant, Anti-Inflammatory, and Anti-Aging Potential of a Kalmia angustifolia Extract and Identification of Some Major Compounds
Antioxidant, Anti-Inflammatory, and Anti-Aging Potential of a Kalmia angustifolia Extract and Identification of Some Major Compounds Open
Skin aging is the most visible element of the aging process, giving rise to a major concern for many people. Plants from the Ericaceae family generally have antioxidant and anti-inflammatory properties, making them potential anti-aging act…
View article: Phenolic Extract from Aralia nudicaulis L. Rhizomes Inhibits Cellular Oxidative Stresses
Phenolic Extract from Aralia nudicaulis L. Rhizomes Inhibits Cellular Oxidative Stresses Open
UV-B and IR-A radiation are important inducers of biological changes in skin involving ROS generation. The overloading of antioxidant defense mechanisms by ROS production could lead to photoaging and photocarcinogenesis processes. Various …
View article: The Biological Activity of Monarda didyma L. Essential Oil and Its Effect as a Diet Supplement in Mice and Broiler Chicken
The Biological Activity of Monarda didyma L. Essential Oil and Its Effect as a Diet Supplement in Mice and Broiler Chicken Open
The use of growth-promoting antibiotics in livestock faces increasing scrutiny and opposition due to concerns about the increased occurrence of antibiotic-resistant bacteria. Alternative solutions are being sought, and plants of Lamiaceae …
View article: Hemisynthesis and Biological Evaluation of Cinnamylated, Benzylated, and Prenylated Dihydrochalcones from a Common Bio-Sourced Precursor
Hemisynthesis and Biological Evaluation of Cinnamylated, Benzylated, and Prenylated Dihydrochalcones from a Common Bio-Sourced Precursor Open
Several families of naturally occurring C-alkylated dihydrochalcones display a broad range of biological activities, including antimicrobial and cytotoxic properties, depending on their alkylation sidechain. The catalytic Friedel–Crafts al…
View article: Isolation and characterization of triterpenoid saponins from leaves of Aralia nudicaulis L
Isolation and characterization of triterpenoid saponins from leaves of Aralia nudicaulis L Open
View article: Total Synthesis, Isolation, Surfactant Properties, and Biological Evaluation of Ananatosides and Related Macrodilactone-Containing Rhamnolipids
Total Synthesis, Isolation, Surfactant Properties, and Biological Evaluation of Ananatosides and Related Macrodilactone-Containing Rhamnolipids Open
Rhamnolipids are a specific class of microbial surfactants, which hold great biotechnological and therapeutic potential. However, their exploitation at the industrial level is hampered because they are mainly produced by the opportunistic …
View article: Total Synthesis, Isolation, Surfactant Properties, and Biological Evaluation of Ananatosides and Related Macrodilactone-Containing Rhamnolipids
Total Synthesis, Isolation, Surfactant Properties, and Biological Evaluation of Ananatosides and Related Macrodilactone-Containing Rhamnolipids Open
Rhamnolipids are a specific class of microbial surfactants, which hold great biotechnological and therapeutic potential. However, their exploitation at the industrial level is hampered because they are mainly produced by the opportunistic …
View article: Total synthesis, isolation, surfactant properties, and biological evaluation of ananatosides and related macrodilactone-containing rhamnolipids
Total synthesis, isolation, surfactant properties, and biological evaluation of ananatosides and related macrodilactone-containing rhamnolipids Open
We show that macrolactonization of gluco- and rhamnolipids dramatically interfere with their surfactant properties and biological activity.
View article: Synthesis and Cytotoxicity of Epiandrosterone Hydrazones
Synthesis and Cytotoxicity of Epiandrosterone Hydrazones Open
View article: Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis
Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis Open
Psoriasis is a skin disorder characterized by epidermal hyperplasia, hyperkeratosis, and inflammation. The treatments currently available on the market only improve patients’ quality of life and are associated with undesirable side effects…