Jean‐Louis Bayart
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View article: <i>Borrelia spielmanii</i>–Associated Neuroborreliosis in Patient Receiving Rituximab, Belgium
<i>Borrelia spielmanii</i>–Associated Neuroborreliosis in Patient Receiving Rituximab, Belgium Open
A 58-year-old woman in Belgium with a history of follicular lymphoma treated with rituximab sought care for a rapid sensory-motor deficit. Seronegative neuroborreliosis caused by Borrelia spielmanii was diagnosed, likely related to humoral…
View article: Vaccine‐induced humoral response of BNT162b2 and mRNA-1273 against BA.1, BA.5, and XBB.1.5. (sub)variants 6 months after a homologous booster: is immunogenicity equivalent?
Vaccine‐induced humoral response of BNT162b2 and mRNA-1273 against BA.1, BA.5, and XBB.1.5. (sub)variants 6 months after a homologous booster: is immunogenicity equivalent? Open
View article: Double trouble: Unmasking two hook effects on Siemens Atellica® - Total PSA and total hCG assays
Double trouble: Unmasking two hook effects on Siemens Atellica® - Total PSA and total hCG assays Open
The "hook effect" or "prozone phenomenon" occurs when the concentration of a particular analyte saturates the antibodies used in the test, resulting in falsely low or negative results despite the presence of high analyte concentrations. We…
View article: Vaccine‐Induced Humoral Response of BNT162b2 and MRNA-1273 Against BA.1, BA.5, and XBB.1.5. (Sub)Variants 6 Months after a Homologous Booster: Is Immunogenicity Equivalent?
Vaccine‐Induced Humoral Response of BNT162b2 and MRNA-1273 Against BA.1, BA.5, and XBB.1.5. (Sub)Variants 6 Months after a Homologous Booster: Is Immunogenicity Equivalent? Open
View article: Evaluation of Neutralizing Capacity of Tixagevimab plus Cilgavimab (AZD7442) against Different SARS‐CoV‐2 Variants: A Case Report Study with Comparison to a Vaccinated Population
Evaluation of Neutralizing Capacity of Tixagevimab plus Cilgavimab (AZD7442) against Different SARS‐CoV‐2 Variants: A Case Report Study with Comparison to a Vaccinated Population Open
AZD7442 (150 mg of tixagevimab plus 150 mg of cilgavimab) has been approved for the preexposure prophylaxis of COVID‐19 and for the treatment of adults and adolescents with COVID‐19 who do not require supplemental oxygen and who are at inc…
View article: Evaluation of neutralizing capacity of tixagevimab plus cilgavimab: a case-series study with comparison to a vaccinated population
Evaluation of neutralizing capacity of tixagevimab plus cilgavimab: a case-series study with comparison to a vaccinated population Open
AZD7442 (150 mg of tixagevimab plus 150 mg cilgavimab) has been approved for the pre-exposure prophylaxis of COVID-19 and for the treatment of adults and adolescents with COVID-19 who do not require supplemental oxygen and who are at incre…
View article: Humoral and cellular response three months following bivalent booster administration
Humoral and cellular response three months following bivalent booster administration Open
Studies about the evaluation of the humoral and cellular response following the bivalent booster administration are still scarce. The aim of this study was to assess the humoral and cellular response in a cohort of healthcare workers that …
View article: Kinetics and ability of binding antibody and surrogate virus neutralization tests to predict neutralizing antibodies against the SARS-CoV-2 Omicron variant following BNT162b2 booster administration
Kinetics and ability of binding antibody and surrogate virus neutralization tests to predict neutralizing antibodies against the SARS-CoV-2 Omicron variant following BNT162b2 booster administration Open
Objectives To assess the long-term humoral immunity induced by booster administration, as well as the ability of binding antibody and surrogate virus neutralization tests (sVNT) to predict neutralizing antibodies (NAbs) against the SARS-Co…
View article: Peri-infection titers of neutralizing and binding antibodies as a predictor of COVID-19 breakthrough infections in vaccinated healthcare professionals: importance of the timing
Peri-infection titers of neutralizing and binding antibodies as a predictor of COVID-19 breakthrough infections in vaccinated healthcare professionals: importance of the timing Open
Objectives The BNT162b2 messenger RNA vaccine is highly effective in reducing COVID‐19 infection, hospitalization and death. However, many subjects developed a breakthrough infection despite a full vaccination scheme. Since the waned effic…
View article: Clinical performance evaluation of the Fluorecare® SARS-CoV-2 & Influenza A/B & RSV rapid antigen combo test in symptomatic individuals
Clinical performance evaluation of the Fluorecare® SARS-CoV-2 & Influenza A/B & RSV rapid antigen combo test in symptomatic individuals Open
View article: Vaccine‐induced binding and neutralizing antibodies against Omicron 6 months after a homologous BNT162b2 booster
Vaccine‐induced binding and neutralizing antibodies against Omicron 6 months after a homologous BNT162b2 booster Open
Evidence about the long‐term persistence of the booster‐mediated immunity against Omicron is mandatory for pandemic management and deployment of vaccination strategies. A total of 155 healthcare professionals (104 COVID‐19 naive and 51 wit…
View article: Nucleocapsid serum antigen determination in SARS-CoV-2 infected patients using the single molecule array technology and prediction of disease severity
Nucleocapsid serum antigen determination in SARS-CoV-2 infected patients using the single molecule array technology and prediction of disease severity Open
View article: Serum SARS-CoV-2 Antigens for the Determination of COVID-19 Severity
Serum SARS-CoV-2 Antigens for the Determination of COVID-19 Severity Open
The diagnostic of SARS-CoV-2 infection relies on reverse transcriptase polymerase chain reactions (RT-PCR) performed on nasopharyngeal (NP) swabs. Nevertheless, false negative results can be obtained with inadequate sampling procedures mak…
View article: Waning of IgG, Total and Neutralizing Antibodies 6 Months Post-Vaccination with BNT162b2 in Healthcare Workers
Waning of IgG, Total and Neutralizing Antibodies 6 Months Post-Vaccination with BNT162b2 in Healthcare Workers Open
Data about the long-term duration of antibodies after SARS-CoV-2 vaccination are still scarce and are important to design vaccination strategies. In this study, 231 healthcare professionals received the two-dose regimen of BNT162b2. Of the…
View article: Waning of IgG, total and neutralizing antibodies 6 months post-vaccination with BNT162b2 in healthcare workers
Waning of IgG, total and neutralizing antibodies 6 months post-vaccination with BNT162b2 in healthcare workers Open
Data about the duration of humoral response following COVID-19 vaccines are mandatory to establish appropriate population vaccination strategy. This study reports on the antibody decline observed in a population of COVID-19 naïve and COVID…
View article: Efficient Maternal to Neonate Transfer of Neutralizing Antibodies after SARS-CoV-2 Vaccination with BNT162b2: A Case-Report and Discussion of the Literature
Efficient Maternal to Neonate Transfer of Neutralizing Antibodies after SARS-CoV-2 Vaccination with BNT162b2: A Case-Report and Discussion of the Literature Open
This case reports on the successful maternal to fetal transfer of neutralizing antibodies after vaccination with BNT162b2 in a pregnant woman at 25 weeks of gestation. The levels of neutralizing antibodies were approximately 5-fold higher …
View article: Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2
Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2 Open
Background: Little is known about potential confounding factors influencing the humoral response in individuals having received the BNT162b2 vaccine. Methods: Blood samples from 231 subjects were collected before and 14, 28, and 42 days fo…
View article: False-positive pregnancy test: beware of familial hCG syndrome
False-positive pregnancy test: beware of familial hCG syndrome Open
TO THE EDITOR, A 41-year-old woman under contraceptive treatment with hormonal intrauterine device and without relevant medical history presented to the emergency department (ED) of the Cliniques Universitaires Saint-Luc in Brussels, Belgi…
View article: A colossal, enigmatic, and long-lasting high-sensitivity cardiac troponin T elevation
A colossal, enigmatic, and long-lasting high-sensitivity cardiac troponin T elevation Open
View article: Confounding Factors Influencing the Kinetic and the Magnitude of Serological Response Following Administration of BNT162b2
Confounding Factors Influencing the Kinetic and the Magnitude of Serological Response Following Administration of BNT162b2 Open
Background: Little is known about potential confounding factors influencing the humoral response in individuals having received the BNT162b2 vaccine. Methods: Blood samples from 231 subjects were collected before and 14, 28 and 42 days fol…
View article: Antibody titers decline 3-month post-vaccination with BNT612b2
Antibody titers decline 3-month post-vaccination with BNT612b2 Open
Introduction: Several studies reported on the humoral response in subjects having received theBNT162b2 mRNA COVID-19 vaccine. However, data on the kinetics of antibodies 3 months postvaccinationare currently lacking and are important to dr…
View article: Early antibody response in health-care professionals after two doses of SARS-CoV-2 mRNA vaccine (BNT162b2)
Early antibody response in health-care professionals after two doses of SARS-CoV-2 mRNA vaccine (BNT162b2) Open
View article: The underestimated issue of non-reproducible cardiac troponin I and T results: case series and systematic review of the literature
The underestimated issue of non-reproducible cardiac troponin I and T results: case series and systematic review of the literature Open
Cardiac troponins (cTn) are the preferred biomarkers for the evaluation of myocardial injury and play a key role in the diagnosis of acute myocardial infarction (MI). Pre-analytical or analytical issues and interferences affecting troponin…
View article: Antibody titres decline 3-month post-vaccination with BNT162b2
Antibody titres decline 3-month post-vaccination with BNT162b2 Open
Several studies reported on the humoral response in subjects having received the BNT162b2 mRNA COVID-19 vaccine. However, data on the kinetics of antibodies 3 months post-vaccination are currently lacking and are important to drive the fut…
View article: Biological variation data and analytical specification goal estimates of the thrombin generation assay with and without thrombomodulin in healthy individuals
Biological variation data and analytical specification goal estimates of the thrombin generation assay with and without thrombomodulin in healthy individuals Open
Background Evaluation of an individual’s thrombin‐generating capacity enables a global assessment of the coagulation cascade and is therefore thought to better reflect the clotting function of blood. However, the lack of standardization st…
View article: Usefulness of a Non-Streptavidin Bead Technology to Overcome Biotin Interference: Proof of Principle with 25-OH Vitamin D, TSH, and FT4
Usefulness of a Non-Streptavidin Bead Technology to Overcome Biotin Interference: Proof of Principle with 25-OH Vitamin D, TSH, and FT4 Open
To the Editor: Biotin interference has become a matter of concern with immunoassays using the biotin-streptavidin immobilization system because of the risk of falsely low and falsely high results observed in sandwich and competitive assays…
View article: A challenging diagnosis of a nonsecretor plasma cell dyscrasia with pleomorphic plasmablastic morphology
A challenging diagnosis of a nonsecretor plasma cell dyscrasia with pleomorphic plasmablastic morphology Open
This report highlights the importance of integrating clinical, radiological, genetic, and pathological laboratory findings to make a correct diagnosis especially with challenging and rare entities.
View article: Analytical and clinical evaluation of new automated chemiluminescent immunoassays for the detection of IgG and IgM anti-Bartonella henselae antibodies
Analytical and clinical evaluation of new automated chemiluminescent immunoassays for the detection of IgG and IgM anti-Bartonella henselae antibodies Open
View article: Neutralization of biotin interference: preliminary evaluation of the VeraTest Biotin™, VeraPrep Biotin™ and BioT-Filter<sup>®</sup>
Neutralization of biotin interference: preliminary evaluation of the VeraTest Biotin™, VeraPrep Biotin™ and BioT-Filter<sup>®</sup> Open
View article: A Challenging Case of Falsely Elevated Free Thyroid Hormones
A Challenging Case of Falsely Elevated Free Thyroid Hormones Open
CASE DESCRIPTION : The patient was a 73-year-old woman suffering from a right calcaneus (heel bone) fracture. She was treated with nebivolol, olmesartan, hydrochlorothiazide, and simvastatine for hypertension and hypercholesterolemia. The …