Jean M. Lewis
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View article: Single step capture and assessment of multiple plasma extracellular vesicle biomarkers in Alzheimer’s disease detection
Single step capture and assessment of multiple plasma extracellular vesicle biomarkers in Alzheimer’s disease detection Open
Background Blood tests for Alzheimer’s disease (AD) that measure biomarkers could be useful as minimally‐invasive ways to give patients more and earlier access to screening. While some AD biomarkers can be detected in plasma, they need to …
View article: Development of a blood-based extracellular vesicle classifier for detection of early-stage pancreatic ductal adenocarcinoma
Development of a blood-based extracellular vesicle classifier for detection of early-stage pancreatic ductal adenocarcinoma Open
Background Pancreatic ductal adenocarcinoma (PDAC) has an overall 5-year survival rate of just 12.5% and thus is among the leading causes of cancer deaths. When detected at early stages, PDAC survival rates improve substantially. Testing h…
View article: Early-stage multi-cancer detection using an extracellular vesicle protein-based blood test
Early-stage multi-cancer detection using an extracellular vesicle protein-based blood test Open
Background Detecting cancer at early stages significantly increases patient survival rates. Because lethal solid tumors often produce few symptoms before progressing to advanced, metastatic disease, diagnosis frequently occurs when surgica…
View article: Simultaneous Isolation of Circulating Nucleic Acids and EV-Associated Protein Biomarkers From Unprocessed Plasma Using an AC Electrokinetics-Based Platform
Simultaneous Isolation of Circulating Nucleic Acids and EV-Associated Protein Biomarkers From Unprocessed Plasma Using an AC Electrokinetics-Based Platform Open
The power of personalized medicine is based on a deep understanding of cellular and molecular processes underlying disease pathogenesis. Accurately characterizing and analyzing connections between these processes is dependent on our abilit…
View article: Plasma Biomarker for Post-concussive Syndrome: A Pilot Study Using an Alternating Current Electro-Kinetic Platform
Plasma Biomarker for Post-concussive Syndrome: A Pilot Study Using an Alternating Current Electro-Kinetic Platform Open
Background: Technology platforms that afford biomarker discovery in patients suffering from traumatic brain injury (TBI) remain an unmet medical need. Here, we describe an observational pilot study to explore the utility of an alter…
View article: A Pilot Proof-Of-Principle Analysis Demonstrating Dielectrophoresis (DEP) as a Glioblastoma Biomarker Platform
A Pilot Proof-Of-Principle Analysis Demonstrating Dielectrophoresis (DEP) as a Glioblastoma Biomarker Platform Open
Extracellular vesicles (EVs) are small, membrane-bound particles released by all cells that have emerged as an attractive biomarker platform. We study the utility of a dielectrophoretic (DEP) micro-chip device for isolation and characteriz…
View article: INNV-19. PLASMA EXTRACELLULAR VESICLE GLIAL FIBRILLARY ACIDIC PROTEIN AND TAU AS BIOMARKERS FOR BRAIN CANCER
INNV-19. PLASMA EXTRACELLULAR VESICLE GLIAL FIBRILLARY ACIDIC PROTEIN AND TAU AS BIOMARKERS FOR BRAIN CANCER Open
Early detection of brain cancer remains a challenging proposition. We applied a novel alternating current electrokinetic (ACE) chip device that relies on the dielectrophoretic (DEP) force to isolate and analyze the proteomic content of ext…