Jean Pastré
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View article: Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial
Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial Open
French Ministry of Health.
View article: Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people Open
View article: Sarcoidosis-Associated Pulmonary Hypertension
Sarcoidosis-Associated Pulmonary Hypertension Open
Sarcoidosis-associated pulmonary hypertension (SAPH) is a very severe complication of the disease, largely impacting its morbidity and being one of its strongest predictors of mortality. With the recent modifications of the hemodynamic def…
View article: A cystic and bullous lung disease associated with a PIK3CA-related overgrowth syndrome
A cystic and bullous lung disease associated with a PIK3CA-related overgrowth syndrome Open
A bullous and cystic lung disease diagnosed in the context of a clinically and genetically diagnosed PROS https://bit.ly/48GnoJy.
View article: High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities
High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities Open
Although sarcoidosis is generally regarded as a benign condition, approximately 20–30% of patients will develop a chronic and progressive disease. Advanced pulmonary fibrotic sarcoidosis and cardiac involvement are the main contributors to…
View article: Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension
Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension Open
View article: Recovery of Endothelium-dependent vascular relaxation impairment in convalescent COVID-19 patients: Insight from a pilot study
Recovery of Endothelium-dependent vascular relaxation impairment in convalescent COVID-19 patients: Insight from a pilot study Open
View article: Proteomic Biomarkers for Survival in Systemic Sclerosis-associated Pulmonary Hypertension
Proteomic Biomarkers for Survival in Systemic Sclerosis-associated Pulmonary Hypertension Open
BACKGROUND : interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc–PH-ILD) generally have a poor p…
View article: External validation and longitudinal application of the DO-GAP index to individualise survival prediction in idiopathic pulmonary fibrosis
External validation and longitudinal application of the DO-GAP index to individualise survival prediction in idiopathic pulmonary fibrosis Open
Background The Distance-Oxygen-Gender-Age-Physiology (DO-GAP) index has been shown to improve prognostication in idiopathic pulmonary fibrosis (IPF) compared to the Gender-Age-Physiology (GAP) score. We sought to externally validate the DO…
View article: Psychometric Properties of a Machine Learning–Based Patient-Reported Outcome Measure on Medication Adherence: Single-Center, Cross-Sectional, Observational Study
Psychometric Properties of a Machine Learning–Based Patient-Reported Outcome Measure on Medication Adherence: Single-Center, Cross-Sectional, Observational Study Open
Background Medication adherence plays a critical role in controlling the evolution of chronic disease, as low medication adherence may lead to worse health outcomes, higher mortality, and morbidity. Assessment of their patients' medication…
View article: Transbronchial cryobiopsy proven amyloid diffuse cystic lung disease complicating a transthyretin mutated (ATTRm) amyloidosis: a case report
Transbronchial cryobiopsy proven amyloid diffuse cystic lung disease complicating a transthyretin mutated (ATTRm) amyloidosis: a case report Open
We present a case report of transbronchial cryobiopsy proven diffuse amyloid cystic lung disease complicating a homozygous Val122Ile (V122I) transthyretin mutated amyloidosis (ATTRm). To the best of our knowledge, this is the first case in…
View article: Psychometric Properties of a Machine Learning–Based Patient-Reported Outcome Measure on Medication Adherence: Single-Center, Cross-Sectional, Observational Study (Preprint)
Psychometric Properties of a Machine Learning–Based Patient-Reported Outcome Measure on Medication Adherence: Single-Center, Cross-Sectional, Observational Study (Preprint) Open
BACKGROUND Medication adherence plays a critical role in controlling the evolution of chronic disease, as low medication adherence may lead to worse health outcomes, higher mortality, and morbidity. Assessment of their patients' medicatio…
View article: Derivation and validation of a simple multidimensional index incorporating exercise capacity parameters for survival prediction in idiopathic pulmonary fibrosis
Derivation and validation of a simple multidimensional index incorporating exercise capacity parameters for survival prediction in idiopathic pulmonary fibrosis Open
Introduction The gender-age-physiology (GAP) index is an easy-to-use baseline mortality prediction model in idiopathic pulmonary fibrosis (IPF). The GAP index does not incorporate exercise capacity parameters such as 6 min walk distance (6…
View article: Risk for Recurrent Venous Thromboembolism in Patients With Subsegmental Pulmonary Embolism Managed Without Anticoagulation
Risk for Recurrent Venous Thromboembolism in Patients With Subsegmental Pulmonary Embolism Managed Without Anticoagulation Open
Heart and Stroke Foundation of Canada and French Ministry of Health Programme Hospitalier de Recherche Clinique.
View article: Sarcoidosis-Like Cancer-Associated Granulomatosis: Characteristics and a Case-Control Comparison with Sarcoidosis
Sarcoidosis-Like Cancer-Associated Granulomatosis: Characteristics and a Case-Control Comparison with Sarcoidosis Open
(1) Background: Systemic granulomatosis developed in a context of malignancy has already been reported. Our objective was to describe the clinical, radiological, functional, biological, and evolutive characteristics of sarcoidosis-like can…
View article: Accuracy of the GAP Score in IPF Patients Treated with Antifibrotic Therapy
Accuracy of the GAP Score in IPF Patients Treated with Antifibrotic Therapy Open
Rationale: The Gender, Age, and Physiology (GAP) index has proven to be an easy tool for predicting disease stage and survival in idiopathic pulmonary fibrosis (IPF) patients.However, how this scoring system performs in the era of antifibr…
View article: Prognosis of Idiopathic Pulmonary Fibrosis in the Antifibrotic Era Stratified by the GAP Score
Prognosis of Idiopathic Pulmonary Fibrosis in the Antifibrotic Era Stratified by the GAP Score Open
Rationale: The impact of antifibrotic treatments on the prognosis of patients with idiopathic pulmonary fibrosis (IPF) is still debated.We sought to evaluate the prognosis of IPF patients and their response to treatment in a large single-c…
View article: Impact of the new definition for pulmonary hypertension in patients with lung disease: an analysis of the United Network for Organ Sharing database
Impact of the new definition for pulmonary hypertension in patients with lung disease: an analysis of the United Network for Organ Sharing database Open
The implications of the recent change in the definition of pulmonary hypertension on epidemiology and outcomes are not known. We sought to determine the percentage of patients with the two most common lung diseases that would be reclassifi…
View article: Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes
Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes Open
Research question There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristic…
View article: Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms
Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms Open
Among patients with chronic obstructive pulmonary disease admitted to the hospital with an acute worsening of respiratory symptoms, pulmonary embolism was detected in 5.9% of patients using a predefined diagnostic algorithm. Further resear…
View article: Does 1-minute walk test predict results of 6-minute walk test in patients with idiopathic pulmonary fibrosis?
Does 1-minute walk test predict results of 6-minute walk test in patients with idiopathic pulmonary fibrosis? Open
The 1MWD obtained during the first minute of a 6MWD shows a strong correlation to total 6MWD and retains its ability to predict transplant-free survival. 1MWT may serve as a practical substitute for the more cumbersome 6MWT. Our findings r…
View article: DOES SURGICAL LUNG BIOPSY CHANGE MANAGEMENT IN HOSPITALIZED PATIENTS WITH SUSPECTED INTERSTITIAL LUNG DISEASE?
DOES SURGICAL LUNG BIOPSY CHANGE MANAGEMENT IN HOSPITALIZED PATIENTS WITH SUSPECTED INTERSTITIAL LUNG DISEASE? Open
View article: Circulating tumour cells as a potential biomarker for lung cancer screening: a prospective cohort study
Circulating tumour cells as a potential biomarker for lung cancer screening: a prospective cohort study Open
View article: IPF Clinical Trial Pulmonary Function Testing Entry Criteria: How Low Can We Go?
IPF Clinical Trial Pulmonary Function Testing Entry Criteria: How Low Can We Go? Open
View article: Development and Validation of a Clinical Diagnostic Score System for the Diagnosis of IPF in Patients with Interstitial Lung Disease
Development and Validation of a Clinical Diagnostic Score System for the Diagnosis of IPF in Patients with Interstitial Lung Disease Open
View article: HRCT Interpretation in Patients with ILD: Out with the Old, In with the New
HRCT Interpretation in Patients with ILD: Out with the Old, In with the New Open
View article: Idiopathic Pulmonary Fibrosis Patients with Severe Physiologic Deficits: Characteristics and Outcomes
Idiopathic Pulmonary Fibrosis Patients with Severe Physiologic Deficits: Characteristics and Outcomes Open
View article: The Zanclean palaeofloras around the Mont-Dore strato-volcano: A window into upper Neogene vegetation and environments in the Massif Central (Puy de Dome, France)
The Zanclean palaeofloras around the Mont-Dore strato-volcano: A window into upper Neogene vegetation and environments in the Massif Central (Puy de Dome, France) Open
View article: HRCT evaluation of patients with interstitial lung disease: comparison of the 2018 and 2011 diagnostic guidelines
HRCT evaluation of patients with interstitial lung disease: comparison of the 2018 and 2011 diagnostic guidelines Open
Background and aims: Chest high-resolution computed tomography (HRCT) is the central diagnostic tool in discerning idiopathic pulmonary fibrosis (IPF) from other interstitial lung disease (ILDs). In 2018, new guidelines were published and …
View article: Peripheral arterial disease and systematic detection of circulating tumor cells: rationale and design of the DETECTOR prospective cohort study
Peripheral arterial disease and systematic detection of circulating tumor cells: rationale and design of the DETECTOR prospective cohort study Open