Jean‐Philippe Antignac
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View article: Determination of Chemical Mixtures in Environmental, Food, and Human Samples Using High-Resolution Mass Spectrometry-Based Suspect Screening Approaches
Determination of Chemical Mixtures in Environmental, Food, and Human Samples Using High-Resolution Mass Spectrometry-Based Suspect Screening Approaches Open
Chemical contaminants are widely dispersed in the environment in all its dimensions, posing significant public health problems. Comprehensive knowledge of these stressors is a prerequisite for assessing the associated risk and implementing…
View article: Correction: Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood
Correction: Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood Open
[This corrects the article DOI: 10.3389/fpubh.2025.1621495.].
View article: Une approche analytique innovante pour un aperçu exhaustif de l'exposition interne humaine aux pesticides
Une approche analytique innovante pour un aperçu exhaustif de l'exposition interne humaine aux pesticides Open
Human exposure to contaminants, including pesticides, is generally estimated using indirect methods. Conventionalbiomonitoring methods remain focused on a limited number of known substances, leaving the risks associated withmultiple exposu…
View article: Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood
Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood Open
Background Perfluorooctanoic acid (PFOA) and Perfluorooctane sulfonate (PFOS) are among numerous chemicals in the Per- and polyfluoroalkylated substances (PFAS) group, which are commonly present in various consumer and industrial products.…
View article: O-034 Gaining insight into the chemical exposome of deep endometriosis using metabolomics
O-034 Gaining insight into the chemical exposome of deep endometriosis using metabolomics Open
Study question Do environmental chemicals play a role on deep endometriosis through metabolic disruption? Summary answer The present study support that women with deep endometriosis exhibit a specific metabolic profile associated to the in…
View article: Characterization of POP mixture redistribution and identification of their molecular signature in xenografted fat mice
Characterization of POP mixture redistribution and identification of their molecular signature in xenografted fat mice Open
View article: Associations between blood levels of persistent organic pollutants and oxidative stress biomarkers among women in France in the 90's
Associations between blood levels of persistent organic pollutants and oxidative stress biomarkers among women in France in the 90's Open
View article: Serum Phthalate Biomarkers, Adipose Tissue Metabolites and 20-Years Incidence of Elevated LDL Levels: A Metabolome-Wide Association Study in the&nbsp;<span>GraMo&nbsp;</span>Cohort
Serum Phthalate Biomarkers, Adipose Tissue Metabolites and 20-Years Incidence of Elevated LDL Levels: A Metabolome-Wide Association Study in the <span>GraMo </span>Cohort Open
View article: Projet exploratoire SYALSA -LactOMICS: Le lait maternel : une interface environnement - système d'alimentation durable - santé
Projet exploratoire SYALSA -LactOMICS: Le lait maternel : une interface environnement - système d'alimentation durable - santé Open
International audience
View article: External quality assurance schemes (EQUASs) and interlaboratory comparison investigations (ICIs) for the human biomonitoring of aromatic amines in urine as part of the quality assurance programme under HBM4EU
External quality assurance schemes (EQUASs) and interlaboratory comparison investigations (ICIs) for the human biomonitoring of aromatic amines in urine as part of the quality assurance programme under HBM4EU Open
Aromatic amines were among the selected chemicals in the HBM4EU project. This paper presents the results of the QA/QC programme (with ICI and EQUAS) to ensure analytical comparability and accuracy of the participating laboratories.
View article: Blood levels of persistent organic pollutants among women in France in the 90's: Main profiles and individual determinants
Blood levels of persistent organic pollutants among women in France in the 90's: Main profiles and individual determinants Open
View article: Opportunities offered by latent-based multiblock strategies to integrate biomarkers of chemical exposure and biomarkers of effect in environmental health studies
Opportunities offered by latent-based multiblock strategies to integrate biomarkers of chemical exposure and biomarkers of effect in environmental health studies Open
Modern environmental epidemiology benefits from a new generation of technologies that enable comprehensive profiling of biomarkers, including environmental chemical exposure and omic datasets. The integration and analysis of large and stru…
View article: Harmonized quality assurance/quality control provisions to assess completeness and robustness of MS1 data preprocessing for LC-HRMS-based suspect screening and non-targeted analysis
Harmonized quality assurance/quality control provisions to assess completeness and robustness of MS1 data preprocessing for LC-HRMS-based suspect screening and non-targeted analysis Open
View article: Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment
Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment Open
View article: Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment
Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment Open
View article: Associations between perfluoroalkyl substances and the severity of non-alcoholic fatty liver disease
Associations between perfluoroalkyl substances and the severity of non-alcoholic fatty liver disease Open
Our study showed a significant association between PFHpA and liver steatosis in NAFLD. According to data available in the literature, PFHpA could be implicated in liver steatosis through β-oxidation and biosynthesis of fatty acids.
View article: Widening exposome exploration by means of complementary HRMS analytical platforms: use case on pesticide exposure
Widening exposome exploration by means of complementary HRMS analytical platforms: use case on pesticide exposure Open
Human exposure to food and environmental contaminants (such as pesticides) is generally estimated by indirect methods. Targeted bio-monitoring is a way to assess the internal exposure on a limited number of substances, needing large sample…
View article: Linking blood oxylipin profiles to internal POPs exposure levels in women undergoing in vitro fertilization
Linking blood oxylipin profiles to internal POPs exposure levels in women undergoing in vitro fertilization Open
View article: Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study
Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study Open
These results support that maternal nutritional status may modulate the effect of prenatal exposure to POPs on childhood overweight/obesity. These findings may help to develop a biological hypothesis for future toxicological studies and to…
View article: Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)
Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021) Open
View article: Mixture risk assessment and human biomonitoring: Lessons learnt from HBM4EU
Mixture risk assessment and human biomonitoring: Lessons learnt from HBM4EU Open
View article: External Quality Assurance Schemes (EQUASs) and Inter-Laboratory Comparison Investigations (ICIs)&nbsp; for Human Biomonitoring of Polycyclic Aromatic Hydrocarbon (PAH) Biomarkers in Urine&nbsp; as Part of the Quality Assurance Programme Under HBM4EU
External Quality Assurance Schemes (EQUASs) and Inter-Laboratory Comparison Investigations (ICIs) for Human Biomonitoring of Polycyclic Aromatic Hydrocarbon (PAH) Biomarkers in Urine as Part of the Quality Assurance Programme Under HBM4EU Open
View article: Partitioning of Persistent Organic Pollutants between Adipose Tissue and Serum in Human Studies
Partitioning of Persistent Organic Pollutants between Adipose Tissue and Serum in Human Studies Open
Blood is the most widely used matrix for biomonitoring of persistent organic pollutants (POPs). It is assumed that POPs are homogenously distributed within body lipids at steady state; however, the variability underlying the partitioning o…
View article: Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach
Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach Open
View article: Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias
Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias Open
Hypospadias is a congenital malformation of penile urethra with unknown etiology in most cases. Persistent organic pollutant (POP) exposure may disrupt endocrine function during a critical window of development of male genitalia. In animal…
View article: Persistent organochlorine pesticides in periprostatic adipose tissue from men with prostate cancer: Ethno-geographic variations, association with disease aggressiveness
Persistent organochlorine pesticides in periprostatic adipose tissue from men with prostate cancer: Ethno-geographic variations, association with disease aggressiveness Open
View article: Impact of mixtures of persistent organic pollutants on breast cancer aggressiveness
Impact of mixtures of persistent organic pollutants on breast cancer aggressiveness Open
These novel findings identified a mixture associated with breast cancer aggressiveness in patients with a BMI > 22 kg/ m2.
View article: The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry
The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry Open
View article: Mixture Risk Assessment of Complex Real-Life Mixtures—The PANORAMIX Project
Mixture Risk Assessment of Complex Real-Life Mixtures—The PANORAMIX Project Open
Humans are involuntarily exposed to hundreds of chemicals that either contaminate our environment and food or are added intentionally to our daily products. These complex mixtures of chemicals may pose a risk to human health. One of the go…
View article: Internal exposure levels of persistent organic pollutants, ovarian function and in vitro fertilization outcomes: a multipollutant analysis
Internal exposure levels of persistent organic pollutants, ovarian function and in vitro fertilization outcomes: a multipollutant analysis Open
Background and Aim Women are exposed to complex mixtures of persistent organic pollutants (POPs), with the potential to interfere with the reproductive system. This study aimed 1) to characterize the internal exposure levels of polychlorin…