Jean Pierre Pallais
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View article: Macrophage-Derived CCL24 Promotes Cardiac Fibrosis Via Fibroblast CCR3
Macrophage-Derived CCL24 Promotes Cardiac Fibrosis Via Fibroblast CCR3 Open
BACKGROUND: Inflammation is a significant risk factor and contributor to the development of cardiovascular disease by driving adaptive and maladaptive responses to cardiac injury. Macrophages are the most abundant immune cells in the heart…
View article: A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide
A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide Open
The complement 3a receptor (C3aR) is a G-protein-coupled receptor (GPCR) involved in inflammatory, metabolic, and neurological diseases. Two endogenous ligands (C3a and TLQP-21) and small molecules (SB290157 and JR14a) differentially signa…
View article: Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism
Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism Open
G protein-coupled receptors (GPCRs) are leading druggable targets for several medicines, but many GPCRs are still untapped for their therapeutic potential due to poor understanding of specific signaling properties. The complement C3a recep…
View article: Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis
Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis Open
The ΔTLQP-21 mouse line can be a valuable resource to conduct mechanistic studies on the necessary role of TLQP-21 in physiology and disease, while also serving as a platform to test the specificity of novel antibodies or immunoassays dire…
View article: Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis
Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis Open
Pro-peptide precursors are processed into biologically active peptide hormones or neurotransmitters, each playing an essential role in physiology and disease. Genetic loss of function of a pro-peptide precursor results in the simultaneous …
View article: The molecular identity of the TLQP-21 peptide receptor
The molecular identity of the TLQP-21 peptide receptor Open
The TLQP-21 neuropeptide has been implicated in functions as diverse as lipolysis, neurodegeneration and metabolism, thus suggesting an important role in several human diseases. Three binding targets have been proposed for TLQP-21: C3aR1, …
View article: Inhibition of Orexin/Hypocretin Neurons Ameliorates Elevated Physical Activity and Energy Expenditure in the A53T Mouse Model of Parkinson’s Disease
Inhibition of Orexin/Hypocretin Neurons Ameliorates Elevated Physical Activity and Energy Expenditure in the A53T Mouse Model of Parkinson’s Disease Open
Aside from the classical motor symptoms, Parkinson’s disease also has various non-classical symptoms. Interestingly, orexin neurons, involved in the regulation of exploratory locomotion, spontaneous physical activity, and energy expenditur…
View article: Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis
Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis Open
Multiple sclerosis (MS) is a T-cell-mediated autoimmune disease of the central nervous system (CNS). Worldwide, more than 2.3 million people are diagnosed with MS. Since its clinical manifestations appear typically in the third and fourth …
View article: Pharmacological and chemogenetic orexin/hypocretin intervention ameliorates Hipp-dependent memory impairment in the A53T mice model of Parkinson’s disease
Pharmacological and chemogenetic orexin/hypocretin intervention ameliorates Hipp-dependent memory impairment in the A53T mice model of Parkinson’s disease Open
Parkinson’s disease (PD), classically defined as a progressive motor disorder accompanied with dopaminergic neuron loss and presence of Lewy bodies, is the second most common neurodegenerative disease. PD also has various non-classical sym…
View article: Chemogenetic Modulation of Orexin Neurons Reverses Changes in Anxiety and Locomotor Activity in the A53T Mouse Model of Parkinson’s Disease
Chemogenetic Modulation of Orexin Neurons Reverses Changes in Anxiety and Locomotor Activity in the A53T Mouse Model of Parkinson’s Disease Open
Parkinson's disease (PD) is the second most common neurodegenerative disease. PD symptomology is recognized as heterogeneous and in addition to motor function decline includes cognitive, mood, sleep, and metabolic disorders. Previous studi…
View article: Activating transcription factor 6α deficiency exacerbates oligodendrocyte death and myelin damage in immune‐mediated demyelinating diseases
Activating transcription factor 6α deficiency exacerbates oligodendrocyte death and myelin damage in immune‐mediated demyelinating diseases Open
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) play a critical role in immune‐mediated demyelinating diseases, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE…