Jean Révilloud
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View article: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Force propagation between epithelial cells depends on active coupling and mechano-structural polarization Open
Cell-generated forces play a major role in coordinating the large-scale behavior of cell assemblies, in particular during development, wound healing, and cancer. Mechanical signals propagate faster than biochemical signals, but can have si…
View article: Author response: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Author response: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization Open
View article: Light-driven biological actuators to probe the rheology of 3D microtissues
Light-driven biological actuators to probe the rheology of 3D microtissues Open
The mechanical properties of biological tissues are key to their physical integrity and function. Although external loading or biochemical treatments allow the estimation of these properties globally, it remains difficult to assess how suc…
View article: The intriguing role of collagen on the rheology of cancer cell spheroids
The intriguing role of collagen on the rheology of cancer cell spheroids Open
View article: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Force propagation between epithelial cells depends on active coupling and mechano-structural polarization Open
Cell-generated forces play a major role in coordinating the large-scale behavior of cell assemblies, in particular during development, wound healing and cancer. Mechanical signals propagate faster than biochemical signals, but can have sim…
View article: The intriguing role of collagen on the rheology of cancer cell spheroids
The intriguing role of collagen on the rheology of cancer cell spheroids Open
View article: Light-driven biological actuators to probe the rheology of 3D microtissues
Light-driven biological actuators to probe the rheology of 3D microtissues Open
The mechanical properties of biological tissues are key to the regulation of their physical integrity and function. Although the application of external loading or biochemical treatments allows to estimate these properties globally, it rem…
View article: Characterization of Loss-Of-Function KCNJ2 Mutations in Atypical Andersen Tawil Syndrome
Characterization of Loss-Of-Function KCNJ2 Mutations in Atypical Andersen Tawil Syndrome Open
Andersen-Tawil Syndrome (ATS) is a rare disease defined by the association of cardiac arrhythmias, periodic paralysis and dysmorphic features, and is caused by KCNJ2 loss-of-function mutations. However, when extracardiac symptoms are atypi…
View article: Viscoelastic Properties in Cancer: From Cells to Spheroids
Viscoelastic Properties in Cancer: From Cells to Spheroids Open
AFM-based rheology methods enable the investigation of the viscoelastic properties of cancer cells. Such properties are known to be essential for cell functions, especially for malignant cells. Here, the relevance of the force modulation m…
View article: Viscoelastic properties in cancer: from cells to spheroids
Viscoelastic properties in cancer: from cells to spheroids Open
View article: Mechanical properties of 3D tumor spheroids measured by AFM
Mechanical properties of 3D tumor spheroids measured by AFM Open
International audience
View article: Functional mapping of the N-terminal arginine cluster and C-terminal acidic residues of Kir6.2 channel fused to a G protein-coupled receptor
Functional mapping of the N-terminal arginine cluster and C-terminal acidic residues of Kir6.2 channel fused to a G protein-coupled receptor Open
Ion channel-coupled receptors (ICCRs) are original man-made ligand-gated ion channels created by fusion of G protein-coupled receptors (GPCRs) to the inward-rectifier potassium channel Kir6.2. GPCR conformational changes induced by ligand …
View article: Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors
Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors Open
Ligand-gated ion channels enable intercellular transmission of action potential through synapses by transducing biochemical messengers into electrical signal. We designed artificial ligand-gated ion channels by coupling G protein-coupled r…
View article: Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues
Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues Open
ATP-sensitive potassium channels (K-ATP channels) play a key role in adjusting the membrane potential to the metabolic state of cells. They result from the unique combination of two proteins: the sulfonylurea receptor (SUR), an ATP-binding…