Jean Xiang Ying Sim
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View article: Severity of respiratory-syncytial-virus and other respiratory viruses versus seasonal influenza amongst hospitalized cancer patients
Severity of respiratory-syncytial-virus and other respiratory viruses versus seasonal influenza amongst hospitalized cancer patients Open
Background More data is required to contextualize disease burden attributable to respiratory-viral-infections (RVIs) in hematology/oncology patients; including vaccine-preventable RVIs (eg. influenza, respiratory-syncytial-virus[RSV]) and …
View article: Building a coronavirus disease 2019 healthcare registry in an evolving pandemic
Building a coronavirus disease 2019 healthcare registry in an evolving pandemic Open
COVID-19 emerged in Wuhan, China in December 2019 and was declared a pandemic on March 11, 2020. As there were many unknowns about COVID-19, an immediate priority early in the pandemic was to collect high-quality data to understand disease…
View article: Severity of respiratory syncytial virus versus SARS-CoV-2 Omicron and influenza infection amongst hospitalized Singaporean adults: a national cohort study
Severity of respiratory syncytial virus versus SARS-CoV-2 Omicron and influenza infection amongst hospitalized Singaporean adults: a national cohort study Open
National Medical Research Council, Singapore.
View article: P-420. Epidemiology of Patients with Laboratory-confirmed <i>Aspergillus</i> species in a Singaporean Hospital
P-420. Epidemiology of Patients with Laboratory-confirmed <i>Aspergillus</i> species in a Singaporean Hospital Open
Background Aspergillus species is an opportunistic mould associated with serious complications, healthcare costs and mortality, especially in immunocompromised patients. WHO has declared Aspergillus fumigatus as a “critical pathogen”. This…
View article: P-410. Gastrointestinal multi-drug resistant bacterial tango in Singapore General Hospital
P-410. Gastrointestinal multi-drug resistant bacterial tango in Singapore General Hospital Open
Background The gastrointestinal tract (GIT) is an ideal reservoir of antibiotic resistance genes where, under antibiotic pressure, multidrug resistant organisms (MDROs) express and disseminate resistance genes via horizontal gene transfer.…
View article: P-706. Adenovirus Type 21 Outbreak among Haematology and liver transplant patients at a large tertiary care hospital in Singapore
P-706. Adenovirus Type 21 Outbreak among Haematology and liver transplant patients at a large tertiary care hospital in Singapore Open
Background Human adenoviruses (HAdVs) commonly cause acute respiratory illness, with documented outbreaks in military settings. HAdV infections frequently precipitate severe pneumonia amongst immunocompromised patients, with associated mor…
View article: Building a Coronavirus Disease 2019 (COVID-19) healthcare registry in an evolving pandemic
Building a Coronavirus Disease 2019 (COVID-19) healthcare registry in an evolving pandemic Open
Objective: COVID-19 emerged in Wuhan, China in December 2019 and was declared a pandemic on March 11, 2020. As there were many unknowns about COVID-19, an immediate priority early in the pandemic was to collect high-quality data to underst…
View article: Incubation Periods of SARS-CoV-2 Wild-Type, Delta, and Omicron Variants–Dominant Periods in Singapore
Incubation Periods of SARS-CoV-2 Wild-Type, Delta, and Omicron Variants–Dominant Periods in Singapore Open
This study in Singapore analysed the incubation periods of the following SARS-CoV-2 variants: Wuhan-Hu-1, Delta, and Omicron. Three pandemic waves were examined: Wuhan-Hu-1 (January 2020–March 2021), Delta (May–October 2021), and Omicron (…
View article: Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study
Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study Open
Duke-NUS Academic Medical Center Nurturing Clinician Researcher Scheme, and the Genedant-GIS Innovation Program.
View article: Comparing automated surveillance systems for detection of pathogen-related clusters in healthcare settings
Comparing automated surveillance systems for detection of pathogen-related clusters in healthcare settings Open
Background Detection of pathogen-related clusters within a hospital is key to early intervention to prevent onward transmission. Various automated surveillance methods for outbreak detection have been implemented in hospital settings. Howe…
View article: Prediction model to identify infectious COVID-19 patients in the emergency department
Prediction model to identify infectious COVID-19 patients in the emergency department Open
Background: Real-time reverse-transcriptase polymerase chain reaction (RT-PCR) has been the gold standard for diagnosing coronavirus disease 2019 (COVID-19) but has a lag time for the results. An effective prediction algorithm for infectio…
View article: Burnout among COVID-19 hospital-based contact tracers in Singapore: results of a mixed-method, cross-sectional multicentre study
Burnout among COVID-19 hospital-based contact tracers in Singapore: results of a mixed-method, cross-sectional multicentre study Open
Introduction: During the coronavirus disease 2019 (COVID-19) pandemic, contact tracers were under immense pressure to deliver effective and timely contact tracing, raising concerns of higher susceptibility to burnout. Our study aimed to de…
View article: 733. The attributable mortality, length of stay, and healthcare costs of methicillin-resistant <i>Staphylococcus aureus</i> infections in Singapore
733. The attributable mortality, length of stay, and healthcare costs of methicillin-resistant <i>Staphylococcus aureus</i> infections in Singapore Open
Background Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are known to compromise patient outcomes and increase healthcare costs. Previous evidence on the prolongation of length of stay due to MRSA infections in Si…
View article: Discovery of the sixth<i>Candida auris</i>clade in Singapore
Discovery of the sixth<i>Candida auris</i>clade in Singapore Open
Summary Background The emerging fungal pathogen Candida auris poses a serious threat to global public health due to its worldwide distribution, multidrug-resistance, high transmissibility, propensity to cause outbreaks and high mortality r…
View article: A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine
A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine Open
Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be another option for disease prevention if demonstrated to be safe and immunogenic. Phas…
View article: Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine
Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine Open
Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. An alternative form of the mRNA vaccine is the self-amplifying mRNA (sa-mRNA) vaccine, which encodes an alphavirus r…
View article: Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes
Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes Open
Ensuring high vaccination and even booster vaccination coverage is critical in preventing severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines currently in use, the mRNA vaccines have shown remarkable effectivene…
View article: Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine
Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine Open
Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. This vaccine platform has been extended to encode an alphavirus replicase that self-amplifies the full length mRNA a…
View article: Favorable vaccine-induced SARS-CoV-2–specific T cell response profile in patients undergoing immune-modifying therapies
Favorable vaccine-induced SARS-CoV-2–specific T cell response profile in patients undergoing immune-modifying therapies Open
BACKGROUNDPatients undergoing immune-modifying therapies demonstrate a reduced humoral response after COVID-19 vaccination, but we lack a proper evaluation of the effect of such therapies on vaccine-induced T cell responses.METHODSWe longi…
View article: Favourable vaccine-induced SARS-CoV-2 specific T cell response profile in patients undergoing immune-modifying therapies
Favourable vaccine-induced SARS-CoV-2 specific T cell response profile in patients undergoing immune-modifying therapies Open
Patients undergoing immune-modifying therapies demonstrate a reduced humoral response after COVID-19 vaccination, but we lack a proper evaluation of the impact of such therapies on vaccine-induced T cell responses. Here, we longitudinally …
View article: <i>Candida glabrata</i> chorioamnionitis in a twin pregnancy following in vitro fertilisation: a rare cause of septic miscarriage
<i>Candida glabrata</i> chorioamnionitis in a twin pregnancy following in vitro fertilisation: a rare cause of septic miscarriage Open
Candida glabrata chorioamnionitis is uncommon and associated with poor fetal outcomes. We present a case of C. glabrata chorioamnionitis of a dichorionic diamniotic pregnancy conceived by fresh embryo transfer. Despite antifungal therapy w…
View article: 392. 3D-DOSS – Using Digital Twins and Spatiotemporal Data Mapping for Infectious Disease Surveillance and Outbreak Investigations
392. 3D-DOSS – Using Digital Twins and Spatiotemporal Data Mapping for Infectious Disease Surveillance and Outbreak Investigations Open
Background The COVID-19 pandemic has brought to light the importance of contact tracing in outbreak management. Digital technologies have been leveraged to enhance contact tracing in community settings. However, within complex hospital env…
View article: 775. Risk Factors for Healthcare Associated Central Line-Associated Bloodstream Infection (CLABSI) to Identify Novel Infection Prevention Areas - A Case-Control Study
775. Risk Factors for Healthcare Associated Central Line-Associated Bloodstream Infection (CLABSI) to Identify Novel Infection Prevention Areas - A Case-Control Study Open
Background The International Nosocomial Infection Control Consortium surveillance reported Central line-associated bloodstream infection (CLABSI) rate of 4.1 per 1000 central-line days in 703 ICUs in 50 countries. Methods At the Singapore …