Jean Sippy
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<span>DNA</span> Packaging Specificity in the λ‐Like Phages: Gifsy‐1 Open
DNA viruses recognize viral DNA and package it into virions. Specific recognition is needed to distinguish viral DNA from host cell DNA. The λ‐like Escherichia coli phages are interesting and good models to examine genome packaging by larg…
DNA Packaging Specificity in the λ-like Phages: Gifsy-1 Open
DNA viruses recognize viral DNA and package it into virions. Specific recognition is needed to distinguish viral DNA from host cell DNA. The λ-like phages are interesting and good models to examine viral DNA packaging, and the Escherichia …
View article: Reviewer #2 (Public Review): Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction
Reviewer #2 (Public Review): Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction Open
Many dsDNA viruses utilize ATP-powered "terminase" motors to package their genomes into procapsid shells. Here we use a single-molecule DNA grip/slip assay with rapid solution exchange to probe effects of nucleotide binding/dissociation in…
View article: Reviewer #1 (Public Review): Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction
Reviewer #1 (Public Review): Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction Open
Many dsDNA viruses utilize ATP-powered "terminase" motors to package their genomes into procapsid shells. Here we use a single-molecule DNA grip/slip assay with rapid solution exchange to probe effects of nucleotide binding/dissociation in…
View article: Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction
Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction Open
Many dsDNA viruses utilize ATP-powered “terminase” motors to package their genomes into procapsid shells. Here we use a single-molecule DNA grip/slip assay with rapid solution exchange to probe effects of nucleotide binding/dissociation in…
View article: Author Response: Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction
Author Response: Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction Open
Many dsDNA viruses utilize ATP-powered "terminase" motors to package their genomes into procapsid shells. Here we use a single-molecule DNA grip/slip assay with rapid solution exchange to probe effects of nucleotide binding/dissociation in…
View article: Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction
Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction Open
Many dsDNA viruses utilize ATP-powered “terminase” motors to package their genomes into procapsid shells. Here we use a single-molecule DNA grip/slip assay with rapid solution exchange to probe effects of nucleotide binding/dissociation in…
View article: Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction
Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction Open
Many dsDNA viruses utilize ATP-powered “terminase” motors to package their genomes into procapsid shells. Here we use a single-molecule DNA grip/slip assay with rapid solution exchange to probe effects of nucleotide binding/dissociation in…
Acidic residues and a predicted, highly conserved α‐helix are critical for the endonuclease/strand separation functions of bacteriophage λ’s TerL Open
Summary Complementation, endonuclease, strand separation, and packaging assays using mutant TerL λ ’s, coupled with bioinformatic information and modeling of its endonuclease, identified five residues, D401, E408, D465, E563, and E586, as …
View article: Evidence that a catalytic glutamate and an ‘Arginine Toggle’ act in concert to mediate ATP hydrolysis and mechanochemical coupling in a viral DNA packaging motor
Evidence that a catalytic glutamate and an ‘Arginine Toggle’ act in concert to mediate ATP hydrolysis and mechanochemical coupling in a viral DNA packaging motor Open
ASCE ATPases include ring-translocases such as cellular helicases and viral DNA packaging motors (terminases). These motors have conserved Walker A and B motifs that bind Mg2+-ATP and a catalytic carboxylate that activates water for hydrol…
DNA Topology and the Initiation of Virus DNA Packaging Open
During progeny assembly, viruses selectively package virion genomes from a nucleic acid pool that includes host nucleic acids. For large dsDNA viruses, including tailed bacteriophages and herpesviruses, immature viral DNA is recognized and…