Jeanmarie R. Gonzalez
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View article: Early life tolerance depends on a subset of specialized dendritic cells and is reinforced by the skin microbiota
Early life tolerance depends on a subset of specialized dendritic cells and is reinforced by the skin microbiota Open
Summary Early life establishment of tolerance to commensal bacteria at barrier surfaces carries enduring implications for immune health but remains poorly understood. Here we show that this process is controlled by microbial interaction wi…
View article: An anti‐siglec‐8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells
An anti‐siglec‐8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells Open
Background Sialic acid‐binding immunoglobulin‐like lectin (Siglec)‐8 is expressed on mast cells and eosinophils, but information about Siglec‐8 expression and function in the lung is limited. A humanized antibody, AK002, targeting Siglec‐8…
View article: Alternative splicing of interleukin-33 and type 2 inflammation in asthma
Alternative splicing of interleukin-33 and type 2 inflammation in asthma Open
Significance Type 2 inflammation occurs in a large subgroup of asthmatics and is the target of multiple novel therapies for asthma; however, the mechanisms that drive type 2 inflammation in chronic asthma are poorly understood. In this stu…