Jeanna M. Wheeler
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View article: Tri-snRNP activity modulates tauopathy phenotypes
Tri-snRNP activity modulates tauopathy phenotypes Open
Alzheimer’s disease (AD) and other tauopathies are neurodegenerative disorders with devastating consequences for cognition and memory. Pathogenic accumulation of tau can be modeled in Caenorhabditis elegans, which recapitulate human neurod…
View article: Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy
Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy Open
View article: Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration
Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration Open
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by clinical symptoms of memory and cognitive deficiencies. Postmortem evaluation of AD brain tissue shows proteinopathy that closely associate with the prog…
View article: Tau–RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change
Tau–RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change Open
Alzheimer’s disease and related disorders feature neurofibrillary tangles and other neuropathological lesions composed of detergent-insoluble tau protein. In recent structural biology studies of tau proteinopathy, aggregated tau forms a di…
View article: Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease Open
View article: Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice Open
The kinase TTBK1 is predominantly expressed in the central nervous system and has been implicated in neurodegenerative diseases including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis through its…
View article: Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain
Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain Open
The poly(A) RNA binding proteins MSUT2 and PABPN1 regulate the accumulation of pathological tau in two mouse models of tauopathy.
View article: DOPA Decarboxylase Modulates Tau Toxicity
DOPA Decarboxylase Modulates Tau Toxicity Open
Loss of the DDC bas-1 reduced tau-induced toxicity in a C. elegans model of tauopathy, while loss of no other dopamine or serotonin synthesis genes tested had this effect. Because loss of activity upstream of DDC could reduce suppression o…
View article: The phosphatase calcineurin regulates pathological TDP-43 phosphorylation
The phosphatase calcineurin regulates pathological TDP-43 phosphorylation Open
View article: High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration
High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration Open