Jeanne Bigot
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View article: The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity
The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity Open
Innate immune memory, also called trained immunity, refers to the ability of innate immune cells to gain memory characteristics after transient stimulation, resulting in a nonspecific modified inflammatory response upon secondary remote ch…
View article: Allergic bronchopulmonary aspergillosis in cystic fibrosis: Case-control study from the French registry
Allergic bronchopulmonary aspergillosis in cystic fibrosis: Case-control study from the French registry Open
Allergic bronchopulmonary aspergillosis (ABPA) is a significant complication in people with cystic fibrosis (pwCF), driven by hypersensitivity to Aspergillus fumigatus. This study aimed to identify factors associated with the development o…
View article: Microsporidiosis in Patients with Autoimmune Diseases Undergoing Monoclonal Antibody Associated Therapy
Microsporidiosis in Patients with Autoimmune Diseases Undergoing Monoclonal Antibody Associated Therapy Open
View article: Antifungal activity of ETD151 against azole-susceptible and -resistant Aspergillus fumigatus clinical isolates
Antifungal activity of ETD151 against azole-susceptible and -resistant Aspergillus fumigatus clinical isolates Open
Aspergillus fumigatus is an opportunistic pathogen responsible for a wide spectrum of severe diseases, depending on the host's immune status. Current therapeutic options against this fungus are limited, and the emergence of resistance agai…
View article: New insights into the echinocandin resistance in<i>Candida</i>spp. in the clinical setting
New insights into the echinocandin resistance in<i>Candida</i>spp. in the clinical setting Open
Despite a huge consumption of echinocandins, the emergence of resistance in Candida spp has remained overall limited. Here, we depicted the epidemiology of Candida spp in our center face to the echinocandins’ consumption. We postulate new …
View article: Molecular epidemiology of<i>Candida africana</i>isolates collected from vagina swabs in French Guiana
Molecular epidemiology of<i>Candida africana</i>isolates collected from vagina swabs in French Guiana Open
Candida africana corresponds to the clade 13 of Candia albicans . It has been mostly involved in vulvovaginal candidiasis worldwide but few data exist in South America. The aim of our study was to investigate the prevalence of C. africana …
View article: Pulmonary Histoplasmosis in People Living with Human Immunodeficiency Virus in French Guiana: Clinical Epidemiology, Medical Imaging and Prognostic
Pulmonary Histoplasmosis in People Living with Human Immunodeficiency Virus in French Guiana: Clinical Epidemiology, Medical Imaging and Prognostic Open
View article: Pulmonary cystic echinococcosis in a child
Pulmonary cystic echinococcosis in a child Open
This case report describes the presentation, diagnosis, and treatment of a 13‐year‐old boy with pulmonary cystic echinococcosis. The patient presented with low‐volume hemoptysis, and lung imaging revealed a large cystic mass, as well as sm…
View article: Effect of Flagellin Pre-Exposure on the Inflammatory and Antifungal Response of Bronchial Epithelial Cells to Fungal Pathogens
Effect of Flagellin Pre-Exposure on the Inflammatory and Antifungal Response of Bronchial Epithelial Cells to Fungal Pathogens Open
Bronchial epithelial cells (BEC) play a crucial role in innate immunity against inhaled fungi. Indeed, in response to microorganisms, BEC synthesize proinflammatory cytokines involved in the recruitment of neutrophils. We have recently sho…
View article: Machine learning to improve the interpretation of intercalating dye-based quantitative PCR results
Machine learning to improve the interpretation of intercalating dye-based quantitative PCR results Open
View article: Usefulness of ß-d-Glucan Assay for the First-Line Diagnosis of Pneumocystis Pneumonia and for Discriminating between Pneumocystis Colonization and Pneumocystis Pneumonia
Usefulness of ß-d-Glucan Assay for the First-Line Diagnosis of Pneumocystis Pneumonia and for Discriminating between Pneumocystis Colonization and Pneumocystis Pneumonia Open
According to the immunodepression status, the diagnosis of Pneumocystis jirovecii pneumonia (PjP) may be difficult. Molecular methods appear very sensitive, but they lack specificity because Pj DNA can be detected in Pneumocystis-colonized…
View article: Antifungal combination therapy for invasive fungal infections in a paediatric oncology and haematology department: A retrospective analysis of practice
Antifungal combination therapy for invasive fungal infections in a paediatric oncology and haematology department: A retrospective analysis of practice Open
View article: Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 Expression
Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 Expression Open
In the coronavirus disease 2019 (COVID-19) health crisis, one major challenge is to identify the susceptibility factors of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in order to adapt the recommendations for populations, …
View article: 410: Pseudomonas aeruginosa modulates SARS-CoV-2 infectivity in CF airway epithelial cells by increasing expression of the host protease TMPRSS2
410: Pseudomonas aeruginosa modulates SARS-CoV-2 infectivity in CF airway epithelial cells by increasing expression of the host protease TMPRSS2 Open
View article: Innate immune memory of bronchial epithelial cells
Innate immune memory of bronchial epithelial cells Open
Les cellules épithéliales bronchiques (CEB) sont essentielles dans la défense immunitaire innée. La mémoire immunitaire innée, décrite chez les macrophages, est la capacité de ces cellules à mémoriser une première stimulation et de réagir …
View article: Flagellin from<i>Pseudomonas aeruginosa</i>modulates SARS-CoV-2 infectivity in CF airway epithelial cells by increasing TMPRSS2 expression
Flagellin from<i>Pseudomonas aeruginosa</i>modulates SARS-CoV-2 infectivity in CF airway epithelial cells by increasing TMPRSS2 expression Open
The major challenge of the COVID-19 health crisis is to identify the factors of susceptibility to SARS-Cov2 in order to adapt the recommendations to the populations and to reduce the risk of getting COVID-19 to the most vulnerable people e…
View article: Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus
Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus Open
Aspergillus fumigatus is an environmental filamentous fungus that can be pathogenic for humans, wherein it is responsible for a large variety of clinical forms ranging from allergic diseases to life-threatening disseminated infectio…
View article: Update on SLC6A14 in lung and gastrointestinal physiology and physiopathology: focus on cystic fibrosis
Update on SLC6A14 in lung and gastrointestinal physiology and physiopathology: focus on cystic fibrosis Open
The solute carrier family 6 member 14 (SLC6A14) protein imports and concentrates all neutral amino acids as well as the two cationic acids lysine and arginine into the cytoplasm of different cell types. Primarily described as involved in s…
View article: Comparison of the MICs Obtained by Gradient Concentration Strip and EUCAST Methods for Four Azole Drugs and Amphotericin B against Azole-Susceptible and -Resistant <i>Aspergillus</i> Section <i>Fumigati</i> Clinical Isolates
Comparison of the MICs Obtained by Gradient Concentration Strip and EUCAST Methods for Four Azole Drugs and Amphotericin B against Azole-Susceptible and -Resistant <i>Aspergillus</i> Section <i>Fumigati</i> Clinical Isolates Open
Reference methods used to assess the drug susceptibilities of Aspergillus fumigatus isolates consisted of EUCAST and CLSI standardized broth microdilution techniques. Considering the increasing rate and the potential impact on the clinical…
View article: Multicentric Evaluation of the Bio-Evolution Toxoplasma gondii Assay for the Detection of<i>Toxoplasma</i>DNA in Immunocompromised Patients
Multicentric Evaluation of the Bio-Evolution Toxoplasma gondii Assay for the Detection of<i>Toxoplasma</i>DNA in Immunocompromised Patients Open
PCR-based methods are a key tool for the diagnosis of toxoplasmosis in immunocompromised patients. Laboratory-developed protocols lack standardization. This study aimed to assess the performances of a commercial kit for the detection of To…
View article: <i>In Vitro</i> Susceptibility of <i>Fusarium</i> to Isavuconazole
<i>In Vitro</i> Susceptibility of <i>Fusarium</i> to Isavuconazole Open
To evaluate the in vitro susceptibility of Fusarium to isavuconazole, 75 clinical isolates were identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry and then tested with a broth microdilution method…