Jeanne Neuffer
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View article: Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro
Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro Open
In Alzheimer’s disease, microglial phagocytosis is engaged in the pathogenesis as it clears abnormal protein accumulations, debris, and apoptotic cells in the early stages of Alzheimer’s disease, but fuels neuroinflammation and accelerates…
View article: Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification
Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification Open
INTRODUCTION An integrative polygenic risk score (iPRS) capturing the neurodegenerative and vascular contribution to dementia could identify high‐risk individuals and improve risk prediction. METHODS We developed an iPRS for dementia (iPRS…
View article: Un meilleur mode de vie est associé à un moindre risque de démence et un moindre déclin cognitif quelle que soit la susceptibilité génétique pour la maladie d’Alzheimer
Un meilleur mode de vie est associé à un moindre risque de démence et un moindre déclin cognitif quelle que soit la susceptibilité génétique pour la maladie d’Alzheimer Open
International audience
View article: Associations of the LIBRA risk score with cognitive resistance to susceptibility genes for dementia
Associations of the LIBRA risk score with cognitive resistance to susceptibility genes for dementia Open
Background Some older adults succeed in maintaining excellent cognition despite high genetic risk for Alzheimer’s disease (AD), reflecting cognitive resistance (CR) to potential neuropathologies. Although the etiological factors for CR are…
View article: Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline
Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline Open
INTRODUCTION Evaluating whether genetic susceptibility modifies the impact of lifestyle‐related factors on dementia is critical for prevention. METHODS We studied 5170 participants from a French cohort of older persons free of dementia at …
View article: Nutrition, mode de vie et prévention du vieillissement cérébral : caractérisation de combinaisons, mécanismes et groupes à risque au moyen de l’épidémiologie moléculaire
Nutrition, mode de vie et prévention du vieillissement cérébral : caractérisation de combinaisons, mécanismes et groupes à risque au moyen de l’épidémiologie moléculaire Open
Dementia is the leading pathology of cognitive ageing. This complex syndrome results from genetic and environmental factors. Lifestyle factors, in particular nutrition, have shown robust associations with cognitive ageing in observational …
View article: A Mediterranean Diet‐Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three‐City Cohort Study
A Mediterranean Diet‐Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three‐City Cohort Study Open
Scope Evidence on the Mediterranean diet (MD) and age‐related cognitive decline (CD) is still inconclusive partly due to self‐reported dietary assessment. The aim of the current study is to develop an MD‐ metabolomic score (MDMS) and inves…
View article: Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons
Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons Open
The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut–brain axis, signal to the brain and influence cognition. Human studies have so far had limited success in identifying early metabolic alterati…