Explanipedia

Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology Open

James Weldon Johnson, Benjamin C. Gadomski, Daniel P. Regan, Jed Johnson, Brad B. Nelson , et al. · 2024

Patient-specific tissue engineered vascular graft for aortic arch reconstruction Open

Hidenori Hayashi, Jacqueline Contento, Kazuyuki Matsushita, Paige Mass, Vincent Cleveland , et al. · 2024

Our patient-specific polycaprolactone/poly-L-lactide-co-ε-caprolactone tissue-engineered vascular grafts demonstrated optimal anatomical fit maintaining ideal hemodynamics and neotissue formation in a porcine model. This study provides a p…

A Protocol for co-Injecting Cells with Pulverized Fibers for Improved Cell Survival and Engraftment Open

Ana I. Salazar‐Puerta, Neil Ott, Ludmila Diaz‐Starokozheva, Devleena Das, William Lawrence , et al. · 2024

Adipose tissue is crucial for medical applications such as tissue reconstruction, cosmetic procedures, and correcting soft tissue deformities. Significant advances in the use of adipose tissue have been achieved through Coleman's studies i…

Evaluation of a novel polymer coil for endovascular occlusion of intracranial aneurysms in a rabbit model Open

David-R. Bisharat, Jed Johnson, Ruben Mühl‐Benninghaus, Toshiki Tomori, James Lago , et al. · 2023

Background and Purpose The results of the preclinical study of a novel polymer coil in treatment of elastase induced aneurysms will be presented in this paper. Material and Methods We induced 16 aneurysms in 16 New Zealand white rabbits at…

Assessing the Biocompatibility and Regeneration of Electrospun‐Nanofiber Composite Tracheal Grafts Open

Lily Kreber, Lumei Liu, Sayali Dharmadhikari, Zheng Hong Tan, Coreena Chan , et al. · 2023

Objective Composite tracheal grafts (CTG) combining decellularized scaffolds with external biomaterial support have been shown to support host‐derived neotissue formation. In this study, we examine the biocompatibility, graft epithelializa…

Validity of Customized Branched Tissue Engineered Vascular Graft in a Porcine Model Open

Hidenori Hayashi, Jacqueline Contento, Kazuyuki Matsushita, Tatsuya Watanabe, Nora Lee , et al. · 2023

Injectable pulverized electrospun poly(lactic‐co‐glycolic acid) fibers improve human adipose tissue engraftment and volume retention Open

Devleena Das, William Lawrence, Ludmila Diaz‐Starokozheva, Ana I. Salazar‐Puerta, Neil Ott , et al. · 2023

Autologous adipose tissue is commonly used for tissue engraftment for the purposes of soft tissue reconstruction due to its relative abundance in the human body and ease of acquisition using liposuction methods. This has led to the adoptio…

Simple fabrication of an electrospun polystyrene microfiber filter that meets<span>N95</span>filtering facepiece respirator filtration and breathability standards Open

Madeline G. Jensen, Patrick T. O’Shaughnessy, Marlee Shaffer, Sooyoun Yu, Yun Young Choi , et al. · 2022

During the global spread of COVID‐19, high demand and limited availability of melt‐blown filtration material led to a manufacturing backlog of N95 Filtering Facepiece Respirators (FFRs). This shortfall prompted the search for alternative f…

Location matters: Offset in tissue-engineered vascular graft implantation location affects wall shear stress in porcine models Open

Jacqueline Contento, Paige Mass, Vincent Cleveland, Seda Aslan, Kazuyuki Matsushita , et al. · 2022

Serial evaluation of segmental esophageal reconstruction using a polyurethane scaffold in a pig model Open

Tiffany L. Sarrafian, Jennifer L. Brazzell, Matthew Barron, Johnathon M. Aho, Ellen W. Blanco , et al. · 2022

The PU scaffold provides a matrix across which formation of new tissue can occur. The mechanisms through which this happens remain unclear, but likely a combination of fibrosis and tissue contraction, in conjunction with new tissue formati…

Novel reinforcement of corrugated nanofiber tissue-engineered vascular graft to prevent aneurysm formation for arteriovenous shunts in an ovine model Open

Kazuyuki Matsushita, Hidenori Hayashi, Katherine Nurminsky, Tyler Dunn, Yusheng He , et al. · 2022

The Imperative to Reimagine Assisted Living Open

Sheryl Zimmerman, Paula Carder, Lindsay Schwartz, Johanna Silbersack, Helena Temkin‐Greener , et al. · 2021

Rotator cuff repair using a bioresorbable nanofiber interposition scaffold: a biomechanical and histologic analysis in sheep Open

Anthony A. Romeo, Jeremiah T. Easley, Daniel P. Regan, Eileen S. Hackett, James Weldon Johnson , et al. · 2021

Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings Open

Lumei Liu, Sayali Dharmadhikari, Robert A. Pouliot, Michael Li, Peter M. Minneci , et al. · 2021

Synthetic scaffolds for the repair of long-segment tracheal defects are hindered by insufficient biocompatibility and poor graft epithelialization. In this study, we determined if extracellular matrix (ECM) coatings improved the biocompati…

Tracheal Macrophages During Regeneration and Repair of Long‐Segment Airway Defects Open

Zheng Hong Tan, Sayali Dharmadhikari, Lumei Liu, Gabrielle Wolter, Kimberly M. Shontz , et al. · 2021

Objectives/Hypothesis Tissue‐engineered tracheal grafts (TETGs) offer a potential solution for repair of long‐segment airway defects. However, preclinical and clinical TETGs have been associated with chronic inflammation and macrophage inf…

Standardization of Microcomputed Tomography for Tracheal Tissue Engineering Analysis Open

Jakob M. Townsend, Robert A. Weatherly, Jed Johnson, Michael S. Detamore · 2020

Tracheal tissue engineering has become an active area of interest among clinical and scientific communities; however, methods to evaluate success of in vivo tissue-engineered solutions remain primarily qualitative. These evaluation …

Applications of Electrospinning for Tissue Engineering in Otolaryngology Open

Ashley Heilingoetter, S. Smith, Prashant Malhotra, Jed Johnson, Tendy Chiang · 2020

Objective: In tissue engineering, biomaterials create a 3D scaffold for cell-to-cell adhesion, proliferation and tissue formation. Because of their similarity to extracellular matrix and architectural adaptability, nanofibers are of partic…

Improving patient outcomes with regenerative medicine: How the Regenerative Medicine Manufacturing Society plans to move the needle forward in cell manufacturing, standards, 3D bioprinting, artificial intelligence-enabled automation, education, and training Open

Joshua Hunsberger, Carl G. Simon, Claudia Zylberberg, Preveen Ramamoorthy, Thomas C. Tubon , et al. · 2020

The Regenerative Medicine Manufacturing Society (RMMS) is the first and only professional society dedicated toward advancing manufacturing solutions for the field of regenerative medicine. RMMS's vision is to provide greater patient access…

Corrugated nanofiber tissue-engineered vascular graft to prevent kinking for arteriovenous shunts in an ovine model Open

Kazuyuki Matsushita, Takahiro Inoue, Sara Abdollahi, Enoch Yeung, Chin Siang Ong , et al. · 2020

Biodegradable electrospun patch containing cell adhesion or antimicrobial compounds for trachea repair <i>in vivo</i> Open

Jakob M. Townsend, Makenna E Hukill, Kar‐Ming Fung, Devan G Ohst, Jed Johnson , et al. · 2019

Difficulty breathing due to tracheal stenosis (i.e. narrowed airway) diminishes the quality of life and can potentially be life-threatening. Tracheal stenosis can be caused by congenital anomalies, external trauma, infection, intubation-re…

Deconstructing tissue engineered trachea: Assessing the role of synthetic scaffolds, segmental replacement and cell seeding on graft performance Open

Sayali Dharmadhikari, Lumei Liu, Kimberly M. Shontz, Matthew Wiet, Audrey White , et al. · 2019

In vivo implantation of 3-dimensional printed customized branched tissue engineered vascular graft in a porcine model Open

Enoch Yeung, Takahiro Inoue, Kazuyuki Matsushita, Justin D. Opfermann, Paige Mass , et al. · 2019

Electrospun scaffolds limit the regenerative potential of the airway epithelium Open

Cynthia Schwartz, Jacob T. Stack, Cynthia L. Hill, Scott W. Lallier, Tendy Chiang , et al. · 2019

Objective Significant morbidity and mortality are associated with clinical use of synthetic tissue‐engineered tracheal grafts (TETG). Our previous work focused on an electrospun polyethylene terephthalate and polyurethane (PET/PU) TETG tha…

Factors Influencing Poor Outcomes in Synthetic Tissue‐Engineered Tracheal Replacement Open

Victoria K. Pepper, Cameron A. Best, Kaila Buckley, Cynthia Schwartz, Ekene Onwuka , et al. · 2019

Objectives Humans receiving tissue‐engineered tracheal grafts have experienced poor outcomes ultimately resulting in death or the need for graft explantation. We assessed the performance of the synthetic scaffolds used in humans with an ov…

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model Open

Matthew Wiet, Sayali Dharmadhikari, Audrey White, Susan D. Reynolds, Jed Johnson , et al. · 2019

Treatment options for congenital or secondary long segment tracheal defects have historically been limited due to an inability to replace functional tissue. Tissue engineering holds great promise as a potential solution with its ability to…

Topical biomaterials to prevent post-tonsillectomy hemorrhage Open

Lumei Liu, Cole Rodman, Noah Worobetz, Jed Johnson, Charles Elmaraghy , et al. · 2019

Despite advances in surgical technique, postoperative hemorrhage remains a common cause of mortality and morbidity for patients following tonsillectomy. Application of biomaterials at the time of tonsillectomy can potentially accelerate mu…

Deconstructing Tissue Engineered Trachea: Assessing the Role of Synthetic Scaffolds, Segmental Replacement and Cell Seeding on Graft Performance Open

Sayali Dharmadhikari, Lumei Liu, Kimberly M. Shontz, Matthew Wiet, Audrey White , et al. · 2019

Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors Open

Yanchun Liu, Yijie Wang, Jason Chakroff, Jed Johnson, Aidan Farrell , et al. · 2018

This study compared side-by-side the impact of donor age on the production of tissue-engineered small intestine (TESI). Each age represents a specific period of life: E18 for fetuses, 5-day-old pups for neonates, 21-day-old rats for weanli…

Solvent Retention in Electrospun Fibers Affects Scaffold Mechanical Properties Open

Anthony R. D’Amato, Michael T. K. Bramson, David T. Corr, Devan L. Puhl, Ryan J. Gilbert , et al. · 2018

Electrospinning is a robust material fabrication method allowing for fine control of mechanical, chemical, and functional properties in scaffold manufacturing. Electrospun fiber scaffolds have gained prominence for their potential in a var…

Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation Open

Cameron A. Best, Takuma Fukunishi, Joseph D. Drews, Ramak Khosravi, Kan N. Hor , et al. · 2018

Most tissue-engineered arterial grafts are complicated by aneurysmal dilation secondary to insufficient neotissue formation after scaffold degradation. The optimal graft would form an organized multilayered structure with a robust extracel…

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