Jeferson Luís Franco
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View article: Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A
Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A Open
Galectins, a family of glycan-binding proteins, play crucial roles in various cellular functions, acting at both intracellular and extracellular levels. Among them, Galectin-3 (Gal-3) stands out as a unique member, possessing an intrinsica…
View article: Effect of foliar sodium selenite fertilization on oxidative stress and productivity in <i>Olea europaea</i> L., biofortification and quality of extra virgin olive oil
Effect of foliar sodium selenite fertilization on oxidative stress and productivity in <i>Olea europaea</i> L., biofortification and quality of extra virgin olive oil Open
Background Fertilization of plants with selenium (Se) can enhance their resistance to abiotic stresses and improve human health and nutrition. However, Se fertilization in olive trees remains underexplored. This study evaluated the effect …
View article: Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A
Galectin-3 Mediated Endocytosis of the Orphan G-Protein-Coupled Receptor GPRC5A Open
Galectins, a family of glycan-binding proteins, play crucial roles in various cellular functions, acting at both intracellular and extracellular levels. Among them, Galectin-3 (Gal-3) stands out as a unique member, possessing an intrinsica…
View article: Assessing the Effects of Palm Oil Consumption on Life Expectancy, Metabolic Markers, and Oxidative Stress in <i>Drosophila melanogaster</i>
Assessing the Effects of Palm Oil Consumption on Life Expectancy, Metabolic Markers, and Oxidative Stress in <i>Drosophila melanogaster</i> Open
Palm oil is the world's second most consumed vegetable oil, sourced from the tropical palm tree Elaeis guineensis . Its consumption has been associated with a higher incidence of cardiovascular disease, largely due to its elevated palmitic…
View article: Increased Iron Levels and Oxidative Stress Mediate Age-Related Impairments in Male and Female Drosophila melanogaster
Increased Iron Levels and Oxidative Stress Mediate Age-Related Impairments in Male and Female Drosophila melanogaster Open
Aging is characterized by a functional decline in the physiological functions and organic systems, causing frailty, illness, and death. Ferroptosis is an iron- (Fe-) dependent regulated cell death, which has been implicated in the pathogen…
View article: Exposure of Zebrafish (Danio rerio) to Clioquinol Reveals Embryological and Developmental Toxicity
Exposure of Zebrafish (Danio rerio) to Clioquinol Reveals Embryological and Developmental Toxicity Open
Clioquinol (CQ) belongs to the 8-hydroxyquinoline family of antimicrobial agents. In the 1970s, CQ was withdrawn from the market due to reported neurotoxicity in humans. Although oral use was discontinued, topical formulations for treating…
View article: Assessing the disparity: comparative toxicity of Copper in zebrafish larvae exposes alarming consequences of permissible concentrations in Brazil
Assessing the disparity: comparative toxicity of Copper in zebrafish larvae exposes alarming consequences of permissible concentrations in Brazil Open
Copper (Cu) is a naturally occurring metal with essential micronutrient properties. However, this metal might also pose increased adverse environmental and health risks due to industrial and agricultural activities. In Brazil, the maximum …
View article: Fungal compound 1-octen-3-ol induces mitochondrial morphological alterations and respiration dysfunctions in Drosophila melanogaster
Fungal compound 1-octen-3-ol induces mitochondrial morphological alterations and respiration dysfunctions in Drosophila melanogaster Open
Fungal volatile organic compounds (VOCs) comprise a group of compounds commonly found in damp or water-damaged indoor places affecting air quality. Indoor fungal pollution is a severe threat to human health, contributing to the onset of al…
View article: Effects of caffeine on brain antioxidant status and mitochondrial respiration in acetaminophen-intoxicated mice
Effects of caffeine on brain antioxidant status and mitochondrial respiration in acetaminophen-intoxicated mice Open
Hepatic encephalopathy is a pathophysiological complication of acute liver failure, which may be triggered by hepatotoxic drugs such as acetaminophen (APAP). Although APAP is safe in therapeutic concentration, APAP overdose may induce neur…
View article: <i>Croton campestris</i> A. St.-Hill Methanolic Fraction in a Chlorpyrifos-Induced Toxicity Model in <i>Drosophila melanogaster</i>: Protective Role of Gallic Acid
<i>Croton campestris</i> A. St.-Hill Methanolic Fraction in a Chlorpyrifos-Induced Toxicity Model in <i>Drosophila melanogaster</i>: Protective Role of Gallic Acid Open
Croton campestris A. St-Hill popularly known as “velame do campo” is a native species of the savannah from northeastern Brazil, being used in folk medicine due to its beneficial effects in the treatment of many diseases, inflammation, deto…
View article: Acute Exposure to Permethrin Modulates Behavioral Functions, Redox, and Bioenergetics Parameters and Induces DNA Damage and Cell Death in Larval Zebrafish
Acute Exposure to Permethrin Modulates Behavioral Functions, Redox, and Bioenergetics Parameters and Induces DNA Damage and Cell Death in Larval Zebrafish Open
Permethrin (PM) is a synthetic pyrethroid insecticide widely used as domestic repellent. Damage effects to nontarget organisms have been reported, particularly in the early stages of development. Studies indicate redox unbalance as seconda…
View article: Determination of the effects of two feed supplements on Drosophila melanogaster
Determination of the effects of two feed supplements on Drosophila melanogaster Open
Pleurotus spp. are considered extremely rich mushroom species from the nutritional pointof view, providing immune-enhancement effects when consumed. However, few mushroomshave been tested for their phenotypic and genotypic responses in ani…
View article: <i>Anacardium microcarpum</i> Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6‐OHDA
<i>Anacardium microcarpum</i> Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6‐OHDA Open
Parkinson’s disease is a degenerative and progressive illness characterized by the degeneration of dopaminergic neurons. 6‐hydroxydopamine (6‐OHDA) is a widespread model for induction of molecular and behavioral alterations similar to Park…
View article: Exposure of <i>Drosophila melanogaster</i> to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP70/83
Exposure of <i>Drosophila melanogaster</i> to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP70/83 Open
Mancozeb (MZ), a manganese‐ and zinc‐containing ethylene‐bis‐dithiocarbamate, is a broad‐spectrum fungicide. Harmful effects of this fungicide have been reported in nontarget organisms via a not fully understood mechanism. Drosophila melan…
View article: Anacardium microcarpum extract and fractions protect against paraquat-induced toxicity in Drosophila melanogaster
Anacardium microcarpum extract and fractions protect against paraquat-induced toxicity in Drosophila melanogaster Open
Anacardium microcarpum Ducke (Anacardiaceae) is a native species of Brazil used in folk medicine for the treatment of several illnesses although its antioxidant activity has been reported in vitro, there is no evidence of this effect in an…
View article: Eugenia uniflora leaf essential oil promotes mitochondrial dysfunction in Drosophila melanogaster through the inhibition of oxidative phosphorylation
Eugenia uniflora leaf essential oil promotes mitochondrial dysfunction in Drosophila melanogaster through the inhibition of oxidative phosphorylation Open
We evaluate the effects of Eugenia uniflora essential oil on mitochondrial bioenergetics in Drosophila melanogaster.
View article: Cytoprotective effect of Eugenia uniflora L. against the waste contaminant mercury chloride
Cytoprotective effect of Eugenia uniflora L. against the waste contaminant mercury chloride Open
Environmental stressors such as mercury are important for the search of substances to lower induced oxidative damage. Accordingly, secondary metabolites from plants with antioxidant activity represent an interesting alternative. The aim of…
View article: HPLC-DAD phenolic profile, cytotoxic and anti-kinetoplastidae activity of<i>Melissa officinalis</i>
HPLC-DAD phenolic profile, cytotoxic and anti-kinetoplastidae activity of<i>Melissa officinalis</i> Open
Context Melissa officinalis subsp. inodora Bornm. (Lamiaceae) has been used since ancient times in folk medicine against various diseases, but it has not been investigated against protozoa. Objective To evaluate the activities of M. offici…
View article: Ethnobotany and antioxidant evaluation of commercialized medicinal plants from the Brazilian Pampa
Ethnobotany and antioxidant evaluation of commercialized medicinal plants from the Brazilian Pampa Open
Despite the importance of medicinal plants for the healthcare of local people, the knowledge about medicinal species used in the Pampa biome has been neglected over the years. In this study, an ethnobotanical survey was employed aiming to …
View article: Phytochemical Composition, Antifungal and Antioxidant Activity of <i>Duguetia furfuracea</i> A. St.‐Hill
Phytochemical Composition, Antifungal and Antioxidant Activity of <i>Duguetia furfuracea</i> A. St.‐Hill Open
Background. Duguetia furfuracea is popular plant used in popular medicine. Hypothesis/Purpose. This claim evaluated the phytochemical composition of the hydroethanolic extract (HEDF), fractions of Duguetia furfuracea , and antioxidant and …
View article: High‐Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression in <i>Drosophila melanogaster</i>
High‐Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression in <i>Drosophila melanogaster</i> Open
The consumption of a high‐fat diet (HFD) causes alteration in normal metabolism affecting lifespan of flies; however molecular mechanism associated with this damage in flies is not well known. This study evaluates the effects of ingestion …