Jeff Caswell
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View article: Antimicrobial susceptibility and genomic determinants of resistance and virulence in Mycoplasma cynos and Mycoplasma felis
Antimicrobial susceptibility and genomic determinants of resistance and virulence in Mycoplasma cynos and Mycoplasma felis Open
Mycoplasma cynos and Mycoplasma felis are important respiratory pathogens in dogs and cats. Due to the challenges of culturing these fastidious bacteria, little is known about their antimicrobial susceptibility or mechanisms of pathogenici…
View article: Integrated MicroRNA–mRNA Sequencing Analysis Identifies Regulators and Networks Involved in Feline Hypertrophic Cardiomyopathy
Integrated MicroRNA–mRNA Sequencing Analysis Identifies Regulators and Networks Involved in Feline Hypertrophic Cardiomyopathy Open
Cardiac remodeling in feline hypertrophic cardiomyopathy (HCM) is poorly understood. To investigate underlying molecular mechanisms, we determined microRNA–mRNA interactions, regulatory networks, and upstream regulators using left ventricl…
View article: Antimicrobial Susceptibility and Genomic Determinants of Resistance and Virulence in <i>Mycoplasma cynos</i> and <i>Mycoplasma felis</i>
Antimicrobial Susceptibility and Genomic Determinants of Resistance and Virulence in <i>Mycoplasma cynos</i> and <i>Mycoplasma felis</i> Open
Mycoplasma cynos and Mycoplasma felis are important respiratory pathogens in dogs and cats. Due to the challenges of culturing these fastidious bacteria, little is known about their antimicrobial susceptibility or mechanisms of pathogenici…
View article: Identification of fibrinogen Aα-chain as an amyloid precursor protein in a case of canine coronary artery amyloidosis
Identification of fibrinogen Aα-chain as an amyloid precursor protein in a case of canine coronary artery amyloidosis Open
Spontaneous amyloid deposition occurs in the coronary arteries in older dogs, but the pathogenesis, including the precursor protein, is not known. We conducted proteome analysis using liquid chromatography–tandem mass spectrometry to ident…
View article: Herd-level occurrence and risk factors associated with respiratory and enteric pathogens from dairy calves in Ontario: A cross-sectional study
Herd-level occurrence and risk factors associated with respiratory and enteric pathogens from dairy calves in Ontario: A cross-sectional study Open
This cross-sectional herd-level study aimed to determine the occurrence of and risk factors for pathogens associated with neonatal calf diarrhea (NCD) and bovine respiratory disease (BRD) on Ontario dairy farms. From April to August 2022, …
View article: Age-Dependent Pathogenesis of Aquatic Bird Bornavirus 1 in Turkeys
Age-Dependent Pathogenesis of Aquatic Bird Bornavirus 1 in Turkeys Open
Aquatic bird bornavirus 1, an orthobornavirus in the family Bornaviridae, displays a broad host range among avian species, including poultry. The pathogenesis of orthobornaviruses is mediated by the host immune response against the infecte…
View article: Evaluation of potential novel biomarkers for feline hypertrophic cardiomyopathy
Evaluation of potential novel biomarkers for feline hypertrophic cardiomyopathy Open
Hypertrophic cardiomyopathy (HCM) is the most common cardiomyopathy in cats. The diagnosis can be difficult, requiring advanced echocardiographic skills. Additionally, circulating biomarkers (N-terminal pro-B type natriuretic peptide and c…
View article: Herd-level risk factors associated with preweaning mortality on Ontario dairy farms
Herd-level risk factors associated with preweaning mortality on Ontario dairy farms Open
The objective of this cross-sectional, herd-level study was to identify associations between calf management practices and herd-level preweaning mortality on Ontario dairy farms. From April to August 2022, a convenience sample of 100 dairy…
View article: Effects of inflammatory stimuli on the development of Mycoplasma bovis pneumonia in experimentally challenged calves
Effects of inflammatory stimuli on the development of Mycoplasma bovis pneumonia in experimentally challenged calves Open
Many cattle infected with Mycoplasma bovis remain healthy while others develop severe chronic respiratory disease. We hypothesized that inflammatory stimuli such as co-pathogens worsen disease outcomes in M. bovis-infected calves. Calves (…
View article: Bovine astrovirus and its role in lymphocytic encephalitis in cattle in Ontario, Canada, 1988–2019
Bovine astrovirus and its role in lymphocytic encephalitis in cattle in Ontario, Canada, 1988–2019 Open
Astroviruses have been found in cattle and other species with encephalitis. Our objective was to determine the frequency of neurotropic bovine astrovirus (BoAstV) in cases of encephalitis in cattle ≥ 4-mo-old. Of 56 cases of idiopathic lym…
View article: Exploring herd-level perinatal calf mortality risk factors in eastern Canadian dairy farms
Exploring herd-level perinatal calf mortality risk factors in eastern Canadian dairy farms Open
This closed cohort study aimed to identify the associations between dairy calf management practices and herd-level perinatal calf mortality risk. From February 2020 to June 2021, predominantly Holstein dairy farms in Québec (n = 1,832) and…
View article: Feline myocardial transcriptome in health and in hypertrophic cardiomyopathy—A translational animal model for human disease
Feline myocardial transcriptome in health and in hypertrophic cardiomyopathy—A translational animal model for human disease Open
Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats, characterized by primary left ventricular hypertrophy. Feline HCM closely resembles human HCM and is suggested as translational animal model for the human disease.…
View article: Bronchopneumonia with interstitial pneumonia in feedlot cattle: Epidemiologic characteristics of affected animals
Bronchopneumonia with interstitial pneumonia in feedlot cattle: Epidemiologic characteristics of affected animals Open
Bronchopneumonia with interstitial pneumonia (BIP) of feedlot cattle is characterized by gross and histologic lesions of cranioventral bronchopneumonia (BP) and caudodorsal interstitial pneumonia. This study described the characteristics a…
View article: Bronchopneumonia with interstitial pneumonia in beef feedlot cattle: Characterization and laboratory investigation
Bronchopneumonia with interstitial pneumonia in beef feedlot cattle: Characterization and laboratory investigation Open
Bronchopneumonia with interstitial pneumonia (BIP) has been considered a variant of acute interstitial pneumonia (AIP) rather than a distinct disease. This study compared 18 BIP, 24 bronchopneumonia (BP), and 13 AIP cases in feedlot beef c…
View article: Laboratory investigation of cases of fatal bacterial pneumonia in dairy cows.
Laboratory investigation of cases of fatal bacterial pneumonia in dairy cows. Open
This study describes seasonal and annual trends, major pathogens, antimicrobial resistance profiles, and suggested predisposing factors in Ontario dairy cows submitted to a diagnostic laboratory for postmortem investigation of pneumonia an…
View article: Juvenile hyperinsulinism in a Maine Coon kitten
Juvenile hyperinsulinism in a Maine Coon kitten Open
Case summary A 5.5 month-old intact male Maine Coon cat was presented to a referral hospital for a history of muscle fasciculations, lethargy and seizures associated with refractory hypoglycemia. Diagnostic testing for hypothyroidism, hypo…
View article: Acute interstitial pneumonia and the biology of 3-methylindole in feedlot cattle
Acute interstitial pneumonia and the biology of 3-methylindole in feedlot cattle Open
Acute interstitial pneumonia (AIP) of cattle has been recognized for many decades. While the pathogenesis and risk factors for this condition in pastured cattle are relatively well characterized, there remains a poor understanding of the d…
View article: The effect of aerosolized bacterial lysate on experimentally induced <i>Mannheimia haemolytica</i> pneumonia in calves.
The effect of aerosolized bacterial lysate on experimentally induced <i>Mannheimia haemolytica</i> pneumonia in calves. Open
Bovine respiratory disease (BRD) often occurs during specific periods of increased susceptibility when stress, viral infection, or reduced air quality are thought to suppress respiratory defences. The innate immune system is rapidly respon…
View article: Reporting guidelines for manuscripts on tumor prognosis
Reporting guidelines for manuscripts on tumor prognosis Open
Keywords neoplasia, observational study design, oncology, pathology, prognostic markers, reporting guidelines, scientific publishing, surgical pathology, veterinary
View article: Protective and Anti-Inflammatory Effects of Protegrin-1 on Citrobacter rodentium Intestinal Infection in Mice
Protective and Anti-Inflammatory Effects of Protegrin-1 on Citrobacter rodentium Intestinal Infection in Mice Open
Infectious intestinal colitis, manifesting as intestinal inflammation, diarrhea, and epithelial barrier disruption, affects millions of humans worldwide and, without effective treatment, can result in death. In addition to this, the signif…
View article: Pathology of the cardiovascular system
Pathology of the cardiovascular system Open
Learning materials for veterinary pathologists and veterinary students, on diagnostic pathology of the cardiovascular system
View article: Gross pathology description and interpretation
Gross pathology description and interpretation Open
These notes supplement the fresh specimens shown in gross pathology laboratories for VETM 3450 intended to develop competence in pathologic description and interpretation. Topics covered include: introduction to pathologic description and …
View article: Effect of aerosolized bacterial lysate on development of naturally occurring respiratory disease in beef calves
Effect of aerosolized bacterial lysate on development of naturally occurring respiratory disease in beef calves Open
Background Bovine respiratory disease (BRD) is a major problem affecting beef cattle after arrival to feedlots. Alternatives to antibiotics are needed for prevention. Hypothesis Stimulation of pulmonary innate immune responses at the time …
View article: Proteomic 2D-DIGE Analysis of Milk Whey from Dairy Cows with Staphylococcus aureus Mastitis Reveals Overexpression of Host Defense Proteins
Proteomic 2D-DIGE Analysis of Milk Whey from Dairy Cows with Staphylococcus aureus Mastitis Reveals Overexpression of Host Defense Proteins Open
Bovine mastitis remains a primary focus of dairy cattle disease research due to its considerable negative economic impact on the dairy industry. Subclinical mastitis (SCM), commonly caused by Staphylococcus aureus, lacks overt clinical sig…
View article: Pulmonary and systemic responses to aerosolized lysate of Staphylococcus aureus and Escherichia coli in calves
Pulmonary and systemic responses to aerosolized lysate of Staphylococcus aureus and Escherichia coli in calves Open
Background Constitutive and inducible defenses protect the respiratory tract from bacterial infection. The objective of this study was to characterize the response to an aerosolized lysate of killed bacteria, as a basis for studying the re…
View article: Mass spectrometry data for proteins in BALF following bacterial lysate
Mass spectrometry data for proteins in BALF following bacterial lysate Open
Mass spectrometry data for proteins in bronchoalveolar lavage fluid in 4 calves (A4, A3, A5, A6) before and 24 hours after aerosolization with heat-killed lysate of Escherichia coli and Staphylococcus aureus.
View article: Additional file 13 of Pulmonary and systemic responses to aerosolized lysate of Staphylococcus aureus and Escherichia coli in calves
Additional file 13 of Pulmonary and systemic responses to aerosolized lysate of Staphylococcus aureus and Escherichia coli in calves Open
Additional file 13. Data.