Jeff Errington
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View article: The zinc bound form of the actinomycete derived natural product compound JBIR-141 induces a mitotic phenotype in fission yeast
The zinc bound form of the actinomycete derived natural product compound JBIR-141 induces a mitotic phenotype in fission yeast Open
This study was designed to identify the natural product compound produced by the actinomycete strain "S149" which is capable of inducing a strong small cell phenotype, called wee, in the fission yeast Schizosaccharomyces pombe. We purified…
View article: Antibiotic fosmidomycin protects bacteria from cell wall perturbations by antagonizing oxidative damage-mediated cell lysis
Antibiotic fosmidomycin protects bacteria from cell wall perturbations by antagonizing oxidative damage-mediated cell lysis Open
Cell wall peptidoglycan is a defining component of bacterial cells, and its biosynthesis is a major target for medically important antibiotics. Recent studies have revealed that antibiotics can kill cells not only by their direct effects o…
View article: Biosynthesis of the quinovosamycin nucleoside antibiotics diverges from that of tunicamycins by additional sugar processing genes
Biosynthesis of the quinovosamycin nucleoside antibiotics diverges from that of tunicamycins by additional sugar processing genes Open
Nucleoside antibiotics tunicamycins and quinovosamycins are closely related microbial natural products with significant antibacterial and antifungal properties. In this study, we identify and elucidate the structure of a new quinovosamycin…
View article: Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A
Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A Open
Persiathiacin A is a novel thiopeptide antibiotic produced by Actinokineospora species UTMC 2448. It has potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis. Thiope…
View article: Roles of PknB and CslA in cell wall morphogenesis of<i>Streptomyces</i>
Roles of PknB and CslA in cell wall morphogenesis of<i>Streptomyces</i> Open
Streptomyces are filamentous bacteria living mostly in the soil and best known for their ability to produce specialised metabolites, including antibiotics. They grow as tip-extending, branching hyphal filaments to form a multicellular myce…
View article: Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2 Open
View article: Biosynthesis of the Quinovosamycin Nucleoside Antibiotics Diverge from Tunicamycins by Additional Sugar Processing Genes
Biosynthesis of the Quinovosamycin Nucleoside Antibiotics Diverge from Tunicamycins by Additional Sugar Processing Genes Open
View article: Chemistry and biology of specialized metabolites produced by <i>Actinomadura</i>
Chemistry and biology of specialized metabolites produced by <i>Actinomadura</i> Open
Actinomadura represents a promising source of natural products. This review emphasizes the specialized metabolites produced by this genus, their biological activities, and selected biosynthetic pathways.
View article: On the mechanisms of lysis triggered by perturbations of bacterial cell wall biosynthesis
On the mechanisms of lysis triggered by perturbations of bacterial cell wall biosynthesis Open
View article: Dissecting the roles of peptidoglycan synthetic and autolytic activities in the walled to L-form bacterial transition
Dissecting the roles of peptidoglycan synthetic and autolytic activities in the walled to L-form bacterial transition Open
Bacterial cells are surrounded by a peptidoglycan (PG) wall, which is a crucial target for antibiotics. It is well known that treatment with cell wall-active antibiotics occasionally converts bacteria to a non-walled “L-form” state that re…
View article: Repurposing drugs with specific activity against L-form bacteria
Repurposing drugs with specific activity against L-form bacteria Open
Cell wall deficient “L- form” bacteria are of growing medical interest as a possible source of recurrent or persistent infection, largely because of their complete resistance to cell wall active antibiotics such as β-lactams. Antibiotics t…
View article: On the mechanisms of lysis triggered by perturbations of bacterial cell wall biosynthesis
On the mechanisms of lysis triggered by perturbations of bacterial cell wall biosynthesis Open
Cell wall synthesis is an essential function for the growth of almost all bacteria, and a major target for our most effective antibiotics. Inhibition of cell wall synthesis by antibiotics such as β-lactams is thought to cause explosive lys…
View article: Discovery of Demurilactone A: A Specific Growth Inhibitor of L-Form <i>Bacillus subtilis</i>
Discovery of Demurilactone A: A Specific Growth Inhibitor of L-Form <i>Bacillus subtilis</i> Open
Metabolic profiling of the extracts from a library of actinobacteria led to the identification of a novel polyketide, demurilactone A, produced by Streptomyces strain DEM21308. The structure of the compound was assigned based on a d…
View article: Mirubactin C rescues the lethal effect of cell wall biosynthesis mutations in Bacillus subtilis
Mirubactin C rescues the lethal effect of cell wall biosynthesis mutations in Bacillus subtilis Open
Growth of most rod-shaped bacteria is accompanied by the insertion of new peptidoglycan into the cylindrical cell wall. This insertion, which helps maintain and determine the shape of the cell, is guided by a protein machine called the rod…
View article: Chromosome remodelling by SMC/Condensin in <i>B. subtilis</i> is regulated by monomeric Soj/ParA during growth and sporulation
Chromosome remodelling by SMC/Condensin in <i>B. subtilis</i> is regulated by monomeric Soj/ParA during growth and sporulation Open
SMC complexes, loaded at ParB- parS sites, are key mediators of chromosome organization in bacteria. ParA/Soj proteins interact with ParB/Spo0J in a pathway involving adenosine triphosphate (ATP)-dependent dimerization and DNA binding, fac…
View article: Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355
Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355 Open
View article: L-Form Switching in Escherichia coli as a Common β-Lactam Resistance Mechanism
L-Form Switching in Escherichia coli as a Common β-Lactam Resistance Mechanism Open
Bacterial L-forms require specialized culture techniques and are neither widely reported nor well understood in human infections. To date, most of the studies have been conducted on Gram-positive and stable L-form bacteria, which usually r…
View article: Systematic whole-genome sequencing reveals an unexpected diversity among actinomycetoma pathogens and provides insights into their antibacterial susceptibilities
Systematic whole-genome sequencing reveals an unexpected diversity among actinomycetoma pathogens and provides insights into their antibacterial susceptibilities Open
Mycetoma is a neglected tropical chronic granulomatous inflammatory disease of the skin and subcutaneous tissues. More than 70 species with a broad taxonomic diversity have been implicated as agents of mycetoma. Understanding the full rang…
View article: Mircubactin B rescues the lethal effect of cell wall biosynthesis mutations in <i>Bacillus subtilis</i>
Mircubactin B rescues the lethal effect of cell wall biosynthesis mutations in <i>Bacillus subtilis</i> Open
Growth of most rod-shaped bacteria is accompanied by the insertion of new peptidoglycan into the cylindrical cell wall. This insertion, which helps maintain and determine the shape of the cell, is guided by a complex protein machinery call…
View article: Discovery, Isolation, Heterologous Expression and Mode of Action Studies of the Antibiotic Polyketide Tatiomicin from Amycolatopsis sp. DEM30355
Discovery, Isolation, Heterologous Expression and Mode of Action Studies of the Antibiotic Polyketide Tatiomicin from Amycolatopsis sp. DEM30355 Open
A genomic and bioactivity informed analysis of the metabolome of the extremophile Amycolatopsis sp. DEM30355 has allowed for the discovery and isolation of the polyketide antibiotic tatiomicin. Identification of the biosynthetic gene clust…
View article: Discovery, Isolation, Heterologous Expression and Mode-of Action Studies of the Antibiotic Polyketide Tatiomicin from Amycolatopsis sp. DEM30355
Discovery, Isolation, Heterologous Expression and Mode-of Action Studies of the Antibiotic Polyketide Tatiomicin from Amycolatopsis sp. DEM30355 Open
A genomic and bioactivity informed analysis of the metabolome of the extremophile Amycolatopsis sp. DEM30355 has allowed for the discovery and isolation of the polyketide antibiotic tatiomicin. Identification of the biosynthetic gene clust…
View article: Systematic whole-genome sequencing reveals an unexpected diversity among actinomycetoma pathogens and provides insights into their antibacterial susceptibilities
Systematic whole-genome sequencing reveals an unexpected diversity among actinomycetoma pathogens and provides insights into their antibacterial susceptibilities Open
Mycetoma is a neglected tropical chronic granulomatous inflammatory disease of the skin and subcutaneous tissues. More than 70 species with a broad taxonomic diversity have been implicated as agents of mycetoma. Understanding the full rang…
View article: Chromosome remodelling by SMC/Condensin in <i>B. subtilis</i> is regulated by Soj/ParA during growth and sporulation
Chromosome remodelling by SMC/Condensin in <i>B. subtilis</i> is regulated by Soj/ParA during growth and sporulation Open
SMC complexes, loaded at ParB- parS sites, are key mediators of chromosome organization in bacteria. ParA/Soj proteins interact with ParB/Spo0J in a pathway involving ATP-dependent dimerization and DNA binding, leading to chromosome segreg…
View article: Characterization of the L-form switch in the Gram-negative pathogen <i>Streptobacillus moniliformis</i>
Characterization of the L-form switch in the Gram-negative pathogen <i>Streptobacillus moniliformis</i> Open
Almost all major classes of bacteria are surrounded by a peptidoglycan cell wall, which is a crucial target for antibiotics. It is now understood that many bacteria can tolerate loss of the cell wall provided that they are in an isotonic e…
View article: CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc
CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc Open
ATP- and GTP-dependent molecular switches are extensively used to control functions of proteins in a wide range of biological processes. However, CTP switches are rarely reported. Here, we report that a nucleoid occlusion protein Noc is a …
View article: L-form switching confers antibiotic, phage and stress tolerance in pathogenic <i>Escherichia coli</i>
L-form switching confers antibiotic, phage and stress tolerance in pathogenic <i>Escherichia coli</i> Open
The bacterial L-form is induced by exposure to cell wall targeting antibiotics or innate immune effectors such as lysozyme and is likely to be important in many human infections. Here, we demonstrate that the osmotically fragile L-form is …
View article: A novel bipartite antitermination system widespread in conjugative elements of Gram-positive bacteria
A novel bipartite antitermination system widespread in conjugative elements of Gram-positive bacteria Open
Transcriptional regulation allows adaptive and coordinated gene expression, and is essential for life. Processive antitermination systems alter the transcription elongation complex to allow the RNA polymerase to read through multiple termi…
View article: Screening and Purification of Natural Products from Actinomycetes that Induce a “Rounded” Morphological Phenotype in Fission Yeast
Screening and Purification of Natural Products from Actinomycetes that Induce a “Rounded” Morphological Phenotype in Fission Yeast Open
This study was designed to identify and investigate bioactive natural product compounds that alter the cellular shape of the fission yeast Schizosaccharomyces pombe and induce a “rounded” or “small” cellular morphological phenotype. Bioass…
View article: CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc
CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc Open
ATP and GTP-dependent molecular switches are extensively used to control functions of proteins in a wide range of biological processes. However, CTP switches are rarely reported. Here, we report that a nucleoid occlusion protein Noc is a C…
View article: Discovery of the Antibiotic Polyketide Tatiomicin via a Genomics Guided Analysis of Amycolatopsis sp. DEM30355
Discovery of the Antibiotic Polyketide Tatiomicin via a Genomics Guided Analysis of Amycolatopsis sp. DEM30355 Open
The application of genomic techniques to the investigation of understudied species of actinobacteria provides an expedited route to the discovery of new bioactive natural products. We report the isolation of the antibiotic polyketide tatio…