Jeff Skinner
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View article: Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial
Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial Open
CIS43LS is a long-acting monoclonal antibody specific for the Plasmodium falciparum circumsporozoite protein expressed on sporozoites. We previously reported that CIS43LS is protective against P. falciparum infection as detected by thick b…
View article: Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein
Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein Open
The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the Plasmodium falciparum circumsporozoite protein (PfCSP). Here, using an antigen-agnostic st…
View article: Infection length and host environment influence on Plasmodium falciparum dry season reservoir
Infection length and host environment influence on Plasmodium falciparum dry season reservoir Open
View article: Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5 Open
View article: Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria
Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria Open
View article: Subcutaneous Administration of a Monoclonal Antibody to Prevent Malaria
Subcutaneous Administration of a Monoclonal Antibody to Prevent Malaria Open
Subcutaneous administration of L9LS to children was protective against P. falciparum infection and clinical malaria over a period of 6 months. (Funded by the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov …
View article: Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses
Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses Open
(Cell Host & Microbe 31, 97–111.e1–e12; January 11, 2023) In Figure 6A, the authors discovered after publication that the neutralization NT50 values of two similar IGHV1-46/IGKV3-20 mAbs (COV30-14 and COV72-37) for several SARS-CoV-2 varia…
View article: Autoantibodies Inhibit Plasmodium falciparum Growth and Associate with Protection from Clinical Malaria
Autoantibodies Inhibit Plasmodium falciparum Growth and Associate with Protection from Clinical Malaria Open
View article: Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses
Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses Open
Humanity has faced three recent outbreaks of novel betacoronaviruses, emphasizing the need to develop approaches that broadly target coronaviruses. Here, we identify 55 monoclonal antibodies from COVID-19 convalescent donors that bind dive…
View article: Safety and Efficacy of a Monoclonal Antibody against Malaria in Mali
Safety and Efficacy of a Monoclonal Antibody against Malaria in Mali Open
CIS43LS was protective against P. falciparum infection over a 6-month malaria season in Mali without evident safety concerns. (Funded by the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov number, NCT043291…
View article: Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season
Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season Open
View article: Broadly neutralizing antibodies target the coronavirus fusion peptide
Broadly neutralizing antibodies target the coronavirus fusion peptide Open
The potential for future coronavirus outbreaks highlights the need to broadly target this group of pathogens. We used an epitope-agnostic approach to identify six monoclonal antibodies that bind to spike proteins from all seven human-infec…
View article: Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support
Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support Open
Several infectious and autoimmune diseases are associated with an expansion of CD21 − CD27 − atypical B cells (atBCs) that up-regulate inhibitory receptors and exhibit altered B cell receptor (BCR) signaling. The function of atBCs remains …
View article: Broadly neutralizing antibodies target the coronavirus fusion peptide
Broadly neutralizing antibodies target the coronavirus fusion peptide Open
The potential for future coronavirus outbreaks highlights the need to develop strategies and tools to broadly target this group of pathogens. Here, using an epitope-agnostic approach, we identified six monoclonal antibodies that bound to s…
View article: Atypical B cells upregulate co-stimulatory molecules during malaria and secrete antibodies with T follicular helper cell support
Atypical B cells upregulate co-stimulatory molecules during malaria and secrete antibodies with T follicular helper cell support Open
Several infectious and autoimmune diseases are associated with an expansion of CD21 - CD27 - atypical B cells (atBCs). The function of atBCs remains unclear and few studies have investigated the biology of pathogen-specific atBCs during ac…
View article: Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern Open
Bispecific antibodies targeting multiple regions of the SARS-CoV-2 spike protein comparably neutralize variants of concern and wild-type virus.
View article: Functional human IgA targets a conserved site on malaria sporozoites
Functional human IgA targets a conserved site on malaria sporozoites Open
A functional human IgA response to malaria targets a conserved epitope in the N terminus of the Plasmodium falciparum circumsporozoite protein.
View article: Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype
Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype Open
In malaria-naïve children and adults, Plasmodium falciparum -infected red blood cells ( Pf -iRBCs) trigger fever and other symptoms of systemic inflammation. However, in endemic areas where individuals experience repeated Pf infections ove…
View article: Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants
Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants Open
The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and therapeutic antibodies underscores the urgent need for new antibody-based tools that potently neutralize variants by targeting multiple sites of the s…
View article: <i>Plasmodium falciparum</i> –specific IgM B cells dominate in children, expand with malaria, and produce functional IgM
<i>Plasmodium falciparum</i> –specific IgM B cells dominate in children, expand with malaria, and produce functional IgM Open
IgG antibodies play a role in malaria immunity, but whether and how IgM protects from malaria and the biology of Plasmodium falciparum (Pf)–specific IgM B cells is unclear. In a Mali cohort spanning infants to adults, we conducted longitud…
View article: Dendritic cell responses to Plasmodium falciparum in a malaria-endemic setting
Dendritic cell responses to Plasmodium falciparum in a malaria-endemic setting Open
View article: Dendritic cell responses to&nbsp;Plasmodium falciparum&nbsp;in a malaria-endemic setting
Dendritic cell responses to Plasmodium falciparum in a malaria-endemic setting Open
Background Plasmodium falciparum causes the majority of malaria cases worldwide and children in sub-Saharan Africa are the most vulnerable group affected. Non-sterile clinical immunity that protects from symptoms develops slowly and is rel…
View article: Dendritic cell responses to Plasmodium falciparum in a malaria-endemic setting
Dendritic cell responses to Plasmodium falciparum in a malaria-endemic setting Open
Background: Plasmodium falciparum causes the majority of malaria cases world-wide, mostly affecting children in sub-Saharan Africa. Non-sterile clinical immunity that protects from symptoms develops slowly and is relatively short-lived. Mo…
View article: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season
Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season Open
View article: <i>Plasmodium falciparum</i>malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype
<i>Plasmodium falciparum</i>malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype Open
In malaria-naïve children and adults, Plasmodium falciparum -infected red blood cells ( Pf -iRBCs) trigger fever and other symptoms of systemic inflammation. However, in endemic areas where individuals experience repeated Pf infections ove…
View article: Strong impact of closing schools, closing bars and wearing masks during the COVID-19 pandemic: results from a simple and revealing analysis
Strong impact of closing schools, closing bars and wearing masks during the COVID-19 pandemic: results from a simple and revealing analysis Open
Many complex mathematical and epidemiological methods have been used to model the Covid-19 pandemic. We took a different approach. Making no assumptions, we simply plotted cases, hospitalizations and deaths, on a log 2 Y axis and a linear …
View article: Dendritic cell responses to&nbsp;Plasmodium falciparum&nbsp;in a malaria-endemic setting
Dendritic cell responses to Plasmodium falciparum in a malaria-endemic setting Open
Background: Plasmodium falciparum causes the majority of malaria cases world-wide, mostly affecting children in sub-Saharan Africa. Non-sterile clinical immunity that protects from symptoms develops slowly and is relatively short-lived. Mo…
View article: <i>Plasmodium falciparum</i>-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM
<i>Plasmodium falciparum</i>-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM Open
IgG antibodies are known to play a central role in naturally acquired immunity to blood-stage malaria in humans, but little is known about the IgM response to blood-stage malaria, the mechanisms by which IgM may protect, or the underlying …
View article: PD-1 Expression on NK Cells in Malaria-Exposed Individuals Is Associated with Diminished Natural Cytotoxicity and Enhanced Antibody-Dependent Cellular Cytotoxicity
PD-1 Expression on NK Cells in Malaria-Exposed Individuals Is Associated with Diminished Natural Cytotoxicity and Enhanced Antibody-Dependent Cellular Cytotoxicity Open
Natural killer (NK) cells are key effector cells of innate resistance capable of destroying tumors and virus-infected cells through cytotoxicity and rapid cytokine production. The control of NK cell responses is complex and only partially …
View article: A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation
A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation Open