Jeffrey S. Berger
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View article: Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health
Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health Open
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with an increased risk of vascular dysfunction and cardiovascular disease. We validate our previously developed Systemic Lupus Erythematosus Activity Platelet-Gene Expressi…
View article: Platelets induce endothelial cell mitochondrial dysfunction in myocardial infarction
Platelets induce endothelial cell mitochondrial dysfunction in myocardial infarction Open
Coronary endothelial dysfunction plays a key role in the pathogenesis of acute coronary syndromes. During myocardial infarction (MI), activated platelets release prothrombotic and proinflammatory factors, contributing to vascular injury an…
View article: Platelets impair the resolution of inflammation in atherosclerotic plaques in insulin-resistant mice after lipid lowering
Platelets impair the resolution of inflammation in atherosclerotic plaques in insulin-resistant mice after lipid lowering Open
Insulin resistance impairs benefits of lipid-lowering treatment, as evidenced by higher cardiovascular disease risk in individuals with type 2 diabetes versus those without. Because platelet activity is higher in insulin-resistant patients…
View article: Association of Lipoprotein(a) With Major Adverse Limb Events and All‐Cause Mortality Following Revascularization for Chronic Limb‐Threatening Ischemia: A Substudy of the BEST‐CLI Trial
Association of Lipoprotein(a) With Major Adverse Limb Events and All‐Cause Mortality Following Revascularization for Chronic Limb‐Threatening Ischemia: A Substudy of the BEST‐CLI Trial Open
Background The BEST‐CLI (Best Endovascular Versus Best Surgical Therapy in Patients With Critical Limb Ischemia) trial tested the optimal initial revascularization strategy in patients with chronic limb‐threatening ischemia. Little is know…
View article: Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction
Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction Open
MBCT-Brief was associated with greater 6-month reductions in stress than an active control among adherent participants. More frequent mindfulness practice was associated with greater improvements in psychological outcomes. Strategies to en…
View article: The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people Open
Background An elevated neutrophil‐lymphocyte ratio (NLR) has been associated with Alzheimer’s disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation in…
View article: Platelet aggregation and ApoE genotypes in the Framingham Heart Study
Platelet aggregation and ApoE genotypes in the Framingham Heart Study Open
Background Apolipoprotein (Apo) E4, a main susceptibility gene for Alzheimer’s disease (AD) is associated with increased vascular dysfunction, amyloid pathology, and neurodegeneration. The effector pathways leading to increased vascular ri…
View article: Prevalence of cardiovascular events in a population-based registry of patients with systemic lupus erythematosus
Prevalence of cardiovascular events in a population-based registry of patients with systemic lupus erythematosus Open
Background The Manhattan Lupus Surveillance Program (MLSP), a population-based retrospective registry of patients with systemic lupus erythematosus (SLE), was used to investigate the prevalence of cardiovascular disease events (CVE) and co…
View article: A Platelet Reactivity ExpreSsion Score derived from patients with peripheral artery disease predicts cardiovascular risk
A Platelet Reactivity ExpreSsion Score derived from patients with peripheral artery disease predicts cardiovascular risk Open
Platelets are key mediators of atherothrombosis, yet, limited tools exist to identify individuals with a hyperreactive platelet phenotype. In this study, we investigate the association of platelet hyperreactivity and cardiovascular events,…
View article: Cardiovascular adverse event reporting in psoriasis and psoriatic arthritis biological therapy clinical trials
Cardiovascular adverse event reporting in psoriasis and psoriatic arthritis biological therapy clinical trials Open
What is known about this subject in regard to women and their families? The prevalence of psoriasis is similar between men and women. Women with psoriasis often respond better to systemic treatments and yet may experience more adverse effe…
View article: Atherosclerosis quantification and cardiovascular risk: the ISCHEMIA trial
Atherosclerosis quantification and cardiovascular risk: the ISCHEMIA trial Open
Background and Aims The aim of this study was to determine the prognostic value of coronary computed tomography angiography (CCTA)–derived atherosclerotic plaque analysis in ISCHEMIA. Methods Atherosclerosis imaging quantitative computed t…
View article: LENSOID BODIES WITHIN THE MIRADOR FORMATION, GALE CRATER - ALPHA PARTICLE X-RAY SPECTROMETER (APXS) GEOCHEMISTRY AND IMPLICATIONS FOR DEPOSITIONAL ENVIRONMENT AND TIMING
LENSOID BODIES WITHIN THE MIRADOR FORMATION, GALE CRATER - ALPHA PARTICLE X-RAY SPECTROMETER (APXS) GEOCHEMISTRY AND IMPLICATIONS FOR DEPOSITIONAL ENVIRONMENT AND TIMING Open
International audience
View article: Operationalizing a 3-year standalone, accelerated medical school curriculum to nurture physicians to become primary care and health system leaders
Operationalizing a 3-year standalone, accelerated medical school curriculum to nurture physicians to become primary care and health system leaders Open
The United States faces a shortage of primary care physicians. To address this, there have been pioneering efforts to develop accelerated pathways with a primary care focused curriculum for undergraduate medical education. The New York Uni…