J. W. Blake
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View article: Sulfotransferase-Mediated Chlorination of 1-Hydroxymethylpyrene to a Mutagen Capable of Penetrating Indicator Cells
Sulfotransferase-Mediated Chlorination of 1-Hydroxymethylpyrene to a Mutagen Capable of Penetrating Indicator Cells Open
Methylated polycyclic aromatic hydrocarbons are common in the human environment. Many of them are stronger carcinogens than their purely aromatic congeners. They may be metabolized to benzylic alcohols. We report here on biochemical and to…
View article: Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating indicator cells.
Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating indicator cells. Open
Methylated polycyclic aromatic hydrocarbons are common in the human environment. Many of them are stronger carcinogens than their purely aromatic congeners. They may be metabolized to benzylic alcohols. We report here on biochemical and to…
View article: Drug Interactions in the Horse: Effects of Chloramphenicol, Quinidine, and Oxyphenbutazone on Phenylbutazone Metabolism
Drug Interactions in the Horse: Effects of Chloramphenicol, Quinidine, and Oxyphenbutazone on Phenylbutazone Metabolism Open
SUMMARY The plasma half-life of phenylbutazone in horses was not increased after pretreatment with chloramphenicol or quinidine, but was increased after oxyphenbutazone. This increased plasma half-life after oxyphenbutazone is consistent w…
View article: The gas-liquid chromatograph and the electron capture detection in equine drug testing.
The gas-liquid chromatograph and the electron capture detection in equine drug testing. Open
Three gas-liquid chromatographic (G.L.C.) procedures discussed have been designed around the four "esses" of detection tests--speed, sensitivity, simplicity, and specificity. These techniques are admirably applicable to the very low plasma…
View article: A review of the pharmacology, pharmacokinetics and behavioral effects of procaine in thoroughbred horses.
A review of the pharmacology, pharmacokinetics and behavioral effects of procaine in thoroughbred horses. Open
Since procaine has both local anaesthetic and central stimulant actions its presence in the blood or urine of racing horses is forbidden. After rapid intravenous injection of procaine HC1 (2.5 mg/Kg) in thoroughbred mares plasma levels of …