Jeffrey C. Horowitz
YOU?
Author Swipe
View article: SARS-CoV-2 innate immune recognition and implications for respiratory health
SARS-CoV-2 innate immune recognition and implications for respiratory health Open
The ongoing global health impact of SARS-CoV-2, particularly on lung and respiratory health, underscores the critical need to decipher the intricate interplay between the virus and the host innate immune system. This review provides an ana…
View article: A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis
A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis Open
The B-cell lymphoma-2 (Bcl-2) family proteins, key regulators of apoptosis, are frequently dysregulated in cancer, tipping the balance of cell survival and apoptosis in favor of survival. The ubiquitin-proteasome system (UPS) is a critical…
View article: The additional accuracy gained by CBCT in shape-sensing robotic bronchoscopy
The additional accuracy gained by CBCT in shape-sensing robotic bronchoscopy Open
View article: BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza
BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza Open
Influenza A viruses (IAVs) pose a significant public health threat, with host factors playing a crucial role in disease severity. We investigated the role of Bcl-2-interacting killer (BIK) in IAV infection using cellular and mouse models, …
View article: Incidental Pulmonary Nodule Detection and Factors Influencing Follow-Up: A Retrospective Study in an Academic Medical Center
Incidental Pulmonary Nodule Detection and Factors Influencing Follow-Up: A Retrospective Study in an Academic Medical Center Open
View article: Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial
Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial Open
Introduction Targeted oxygenation protocols in mechanically ventilated patients are critical in avoiding the deleterious effects of hypoxaemia and hyperoxaemia. Peripheral oxygen saturation (SpO2) is a practical metric that commonly drives…
View article: Recurrent Endobronchial Coil Migration Associated With Needle Biopsy Following Pulmonary Artery Pseudoaneurysm Embolization
Recurrent Endobronchial Coil Migration Associated With Needle Biopsy Following Pulmonary Artery Pseudoaneurysm Embolization Open
Endobronchial coil migration is a rare complication of pulmonary artery embolization, occurring when coils erode through a vessel into an airway. We describe a patient who underwent embolization of pulmonary artery pseudoaneurysms associat…
View article: PAI-1 interaction with sortilin-related receptor 1 is required for lung fibrosis
PAI-1 interaction with sortilin-related receptor 1 is required for lung fibrosis Open
Mutation studies of plasminogen activator inhibitor 1 (PAI-1) have previously implied that PAI-1 promotes lung fibrosis via a vitronectin-dependent (VTN-dependent) mechanism. In the present study, employing 2 distinct murine fibrosis model…
View article: Plasma proteomic profiles correlate with organ dysfunction in COVID‐19 ARDS
Plasma proteomic profiles correlate with organ dysfunction in COVID‐19 ARDS Open
Severe COVID‐19 is often complicated by hypoxemic respiratory failure and acute respiratory distress syndrome (ARDS). Mechanisms governing lung injury and repair in ARDS remain poorly understood. We hypothesized that plasma proteomics may …
View article: Role of glycosylation mutations at the N-terminal domain of SARS-CoV-2 XEC variant in immune evasion, cell-cell fusion, and spike stability
Role of glycosylation mutations at the N-terminal domain of SARS-CoV-2 XEC variant in immune evasion, cell-cell fusion, and spike stability Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, producing new variants that drive global coronavirus disease 2019 surges. XEC, a recombinant of KS.1.1 and KP.3.3, contains T22N and F59S mutations in the sp…
View article: Neutralization and spike stability of JN.1-derived LB.1, KP.2.3, KP.3, and KP.3.1.1 subvariants
Neutralization and spike stability of JN.1-derived LB.1, KP.2.3, KP.3, and KP.3.1.1 subvariants Open
During the summer of 2024, coronavirus disease 2019 (COVID-19) cases surged globally, driven by variants derived from JN.1 subvariants of severe acute respiratory syndrome coronavirus 2 that feature new mutations, particularly in the N-ter…
View article: Immune Evasion, Cell-Cell Fusion, and Spike Stability of the SARS-CoV-2 XEC Variant: Role of Glycosylation Mutations at the N-terminal Domain
Immune Evasion, Cell-Cell Fusion, and Spike Stability of the SARS-CoV-2 XEC Variant: Role of Glycosylation Mutations at the N-terminal Domain Open
SUMMARY SARS-CoV-2 continues to evolve, producing new variants that drive global COVID-19 surges. XEC, a recombinant of KS.1.1 and KP.3.3, contains T22N and F59S mutations in the spike protein’s N-terminal domain (NTD). The T22N mutation, …
View article: Neutralization and Stability of JN.1-derived LB.1, KP.2.3, KP.3 and KP.3.1.1 Subvariants
Neutralization and Stability of JN.1-derived LB.1, KP.2.3, KP.3 and KP.3.1.1 Subvariants Open
SUMMARY During the summer of 2024, COVID-19 cases surged globally, driven by variants derived from JN.1 subvariants of SARS-CoV-2 that feature new mutations, particularly in the N-terminal domain (NTD) of the spike protein. In this study, …
View article: Eosinophilic reactive airways disease after immune checkpoint inhibitor treatment
Eosinophilic reactive airways disease after immune checkpoint inhibitor treatment Open
Immune checkpoint inhibitors (ICI) are increasingly utilized as first‐line treatment for many solid tumour malignancies. One downside of ICI therapy is autoimmune‐mediated organ inflammation, or immune‐related adverse events (irAE). ICI‐re…
View article: PAI-1 Interaction with Sortilin Related Receptor-1 is Required for Lung Fibrosis
PAI-1 Interaction with Sortilin Related Receptor-1 is Required for Lung Fibrosis Open
Plasminogen activator inhibitor-1 (PAI-1) has been previously shown to promote lung fibrosis via a mechanism that requires an intact vitronectin (VTN) binding site. In the present study, employing two distinct murine fibrosis models, we fi…
View article: Longitudinal transcriptomic analysis reveals persistent enrichment of iron homeostasis and erythrocyte function pathways in severe COVID-19 ARDS
Longitudinal transcriptomic analysis reveals persistent enrichment of iron homeostasis and erythrocyte function pathways in severe COVID-19 ARDS Open
Introduction The acute respiratory distress syndrome (ARDS) is a common complication of severe COVID-19 and contributes to patient morbidity and mortality. ARDS is a heterogeneous syndrome caused by various insults, and results in acute hy…
View article: Neutralization escape, infectivity, and membrane fusion of JN.1-derived SARS-CoV-2 SLip, FLiRT, and KP.2 variants
Neutralization escape, infectivity, and membrane fusion of JN.1-derived SARS-CoV-2 SLip, FLiRT, and KP.2 variants Open
View article: Characteristics of JN.1-derived SARS-CoV-2 subvariants SLip, FLiRT, and KP.2 in neutralization escape, infectivity and membrane fusion
Characteristics of JN.1-derived SARS-CoV-2 subvariants SLip, FLiRT, and KP.2 in neutralization escape, infectivity and membrane fusion Open
SUMMARY SARS-CoV-2 variants derived from the immune evasive JN.1 are on the rise worldwide. Here, we investigated JN.1-derived subvariants SLip, FLiRT, and KP.2 for their ability to be neutralized by antibodies in bivalent-vaccinated human…
View article: Distinct patterns of SARS-CoV-2 BA.2.87.1 and JN.1 variants in immune evasion, antigenicity, and cell-cell fusion
Distinct patterns of SARS-CoV-2 BA.2.87.1 and JN.1 variants in immune evasion, antigenicity, and cell-cell fusion Open
The rapid evolution of SARS-CoV-2 variants presents a constant challenge to the global vaccination effort. In this study, we conducted a comprehensive investigation into two newly emerged variants, BA.2.87.1 and JN.1, focusing on their neu…
View article: Distinct Patterns of SARS-CoV-2 BA.2.87.1 and JN.1 Variants in Immune Evasion, Antigenicity and Cell-Cell Fusion
Distinct Patterns of SARS-CoV-2 BA.2.87.1 and JN.1 Variants in Immune Evasion, Antigenicity and Cell-Cell Fusion Open
The rapid evolution of SARS-CoV-2 variants presents a constant challenge to the global vaccination effort. In this study, we conducted a comprehensive investigation into two newly emerged variants, BA.2.87.1 and JN.1, focusing on their neu…
View article: Corrigendum: Brief research report: impact of vaccination on antibody responses and mortality from severe COVID-19
Corrigendum: Brief research report: impact of vaccination on antibody responses and mortality from severe COVID-19 Open
[This corrects the article DOI: 10.3389/fimmu.2024.1325243.].
View article: Brief research report: impact of vaccination on antibody responses and mortality from severe COVID-19
Brief research report: impact of vaccination on antibody responses and mortality from severe COVID-19 Open
Introduction While it is established that vaccination reduces risk of hospitalization, there is conflicting data on whether it improves outcome among hospitalized COVID-19 patients. This study evaluated clinical outcomes and antibody (Ab) …
View article: Effect of SARS-CoV-2 IgG Seroconversion After Convalescent Plasma Transfusion on Hospital Outcomes in COVID-19
Effect of SARS-CoV-2 IgG Seroconversion After Convalescent Plasma Transfusion on Hospital Outcomes in COVID-19 Open
Background: Convalescent plasma increases SARS-CoV-2 clearance in COVID-19, especially in patients lacking pre-existing antibodies.Research Question: In hospitalized COVID-19 patients receiving convalescent plasma, does conversion to a pos…
View article: Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA.2.86 and FLip variants
Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA.2.86 and FLip variants Open
View article: RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension
RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension Open
Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with limited treatment options. Endothelial dysfunction plays a central role in the development and progression of PAH, yet the underlying mechanisms are incomp…
View article: Synergistic Role of NK Cells and Monocytes in Promoting Atherogenesis in Severe COVID-19 Patients
Synergistic Role of NK Cells and Monocytes in Promoting Atherogenesis in Severe COVID-19 Patients Open
Clinical data demonstrate an increased predisposition to cardiovascular disease (CVD) following severe COVID-19 infection. This may be driven by a dysregulated immune response associated with severe disease. Monocytes and vascular tissue r…
View article: Immune Evasion, Infectivity, and Fusogenicity of SARS-CoV-2 Omicron BA.2.86 and FLip Variants
Immune Evasion, Infectivity, and Fusogenicity of SARS-CoV-2 Omicron BA.2.86 and FLip Variants Open
Evolution of SARS-CoV-2 requires the reassessment of current vaccine measures. Here, we characterized BA.2.86 and the XBB-lineage variant FLip by investigating their neutralization alongside D614G, BA.1, BA.2, BA.4/5, XBB.1.5, and EG.5.1 b…
View article: Increased COVID-19 Mortality and Deficient SARS-CoV-2 Immune Response Are Not Associated with Higher Levels of Endemic Coronavirus Antibodies
Increased COVID-19 Mortality and Deficient SARS-CoV-2 Immune Response Are Not Associated with Higher Levels of Endemic Coronavirus Antibodies Open
The impact of pre-existing common cold coronavirus (CCCoV) antibodies (Abs) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and pathogenesis remains poorly defined. We evaluated these associations in a coho…
View article: Persistent hypoxia promotes myofibroblast differentiation via <scp>GPR</scp>‐81 and differential regulation of <scp>LDH</scp> isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts
Persistent hypoxia promotes myofibroblast differentiation via <span>GPR</span>‐81 and differential regulation of <span>LDH</span> isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts Open
Hypoxia, a state of insufficient oxygen availability, promotes cellular lactate production. Lactate levels are increased in lungs from patients with idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive scar formation, …
View article: The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype Open
Aging is the most prominent nonmodifiable risk factor for various human diseases including Idiopathic pulmonary fibrosis. Aging progressively alters extracellular matrix components and is associated with the accumulation of senescent cells…