Jeffrey Chen
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View article: Price determinants and pricing policies concerning potentially innovative health technologies: a scoping review
Price determinants and pricing policies concerning potentially innovative health technologies: a scoping review Open
Background Policymakers face challenges in developing pricing policies for potentially innovative healthcare technologies (pIHTs) that balance limited budgets, access, and incentives for innovation. This study aimed to map existing evidenc…
View article: Predictors of blood loss, operative time, and length of stay in adult spinal deformity surgery: a retrospective cohort study in Southeastern United States
Predictors of blood loss, operative time, and length of stay in adult spinal deformity surgery: a retrospective cohort study in Southeastern United States Open
Three-column osteotomy was the strongest predictor of perioperative morbidity in ASD surgery, consistently associated with higher blood loss, longer operative times, and prolonged hospital stays. Recognizing its impact can inform surgical …
View article: Assessing a dire fate: Standard gamble and time trade-off utilities for states worse than dead
Assessing a dire fate: Standard gamble and time trade-off utilities for states worse than dead Open
Health utilities, which reflect how people value health conditions, are often elicited using the composite time trade-off (cTTO) method. This asks people how many years they would give up to avoid living in impaired health states. However,…
View article: Feasibility of an Electronic Nose to Aid Biochemical Assessment of Adrenal Lesions
Feasibility of an Electronic Nose to Aid Biochemical Assessment of Adrenal Lesions Open
While slight differences in VOC patterns were detected between functional and nonfunctional adrenal lesions, the electronic nose demonstrated limited discriminative value for clinical practice.
View article: Positivity properties of $q$-hit numbers in the finite general linear group
Positivity properties of $q$-hit numbers in the finite general linear group Open
We consider the problem of counting matrices over a finite field with fixed rank and support contained in a fixed set. The count of such matrices gives a $q$-analogue of the classical rook and hit numbers, known as the $q$-rook and $q$-hit…
View article: Isolated calvarial lesion as the initial presentation of metastatic hepatocellular carcinoma: A case report and review of the literature
Isolated calvarial lesion as the initial presentation of metastatic hepatocellular carcinoma: A case report and review of the literature Open
Background: Hepatocellular carcinoma (HCC) contributes significantly to global cancer-related mortality, often because patients present at advanced stages of the disease. HCC commonly metastasizes to the lung, abdominal lymph nodes, and bo…
View article: Yeast catalysis of hydrogen peroxide as an enhanced chemical treatment method for harvested rainwater
Yeast catalysis of hydrogen peroxide as an enhanced chemical treatment method for harvested rainwater Open
Rainwater is frequently collected at home for many reasons, so household methods of rainwater treatment are necessary for convenience. Usually, the chlorination process with hypochlorite (ClO-) bleach is used, but hydrogen peroxide (H2O2) …
View article: Evaluating the prevalence of psychiatric comorbidities associated with pediatric scoliosis utilizing ResearchMatch
Evaluating the prevalence of psychiatric comorbidities associated with pediatric scoliosis utilizing ResearchMatch Open
Purpose The goal of this study is to characterize the self-reported prevalence of psychiatric comorbidities among patients with adolescent scoliosis. Methods Eligible patients across the US were surveyed using ResearchMatch, a validated on…
View article: Comparing the Upper Instrumented Vertebrae Tilt Angle vs Screw Angle in the Development of Proximal Junction Kyphosis After Adult Spinal Deformity Surgery: Which Matters More?
Comparing the Upper Instrumented Vertebrae Tilt Angle vs Screw Angle in the Development of Proximal Junction Kyphosis After Adult Spinal Deformity Surgery: Which Matters More? Open
BACKGROUND: We sought to determine which aspect of the upper instrumented vertebrae (UIV)—tilt angle or screw angle—was more strongly associated with: (1) proximal junctional kyphosis/failure (PJK/F), (2) other mechanical complications and…
View article: Impact of Targeted Systemic Therapy and Radiotherapy on Patients Undergoing Spine Surgery for Metastatic Renal Cell Carcinoma
Impact of Targeted Systemic Therapy and Radiotherapy on Patients Undergoing Spine Surgery for Metastatic Renal Cell Carcinoma Open
BACKGROUND: In patients undergoing spine surgery for renal cell carcinoma (RCC), we sought to: (1) describe patterns of postoperative targeted systemic therapy and radiotherapy (RT), (2) compare perioperative outcomes among those treated w…
View article: Predictors of acute post-thrombectomy intracranial hemorrhage expansion in anterior circulation infarcts
Predictors of acute post-thrombectomy intracranial hemorrhage expansion in anterior circulation infarcts Open
Background Post-mechanical thrombectomy (MT) intracranial hemorrhage (ICH) is a major source of morbidity in treated acute ischemic stroke patients with large vessel occlusion. ICH expansion may further contribute to morbidity. We sought t…
View article: Who Can Be Discharged Home after Adult Spinal Deformity Surgery?
Who Can Be Discharged Home after Adult Spinal Deformity Surgery? Open
Introduction: After adult spinal deformity (ASD) surgery, patients often require postoperative rehabilitation at an inpatient rehabilitation (IPR) center or a skilled nursing facility (SNF). However, home discharge is often preferred by pa…
View article: Combined Anterior–Posterior vs. Posterior-Only Approach in Adult Spinal Deformity Surgery: Which Strategy Is Superior?
Combined Anterior–Posterior vs. Posterior-Only Approach in Adult Spinal Deformity Surgery: Which Strategy Is Superior? Open
Introduction: Whether a combined anterior–posterior (AP) approach offers additional benefits over the posterior-only (P) approach in adult spinal deformity (ASD) surgery remains unknown. In a cohort of patients undergoing ASD surgery, we c…
View article: False positive metastatic disease due to combined thoracic and subcutaneous splenosis
False positive metastatic disease due to combined thoracic and subcutaneous splenosis Open
A 56-year-old man presented with dyspnea secondary to pulmonary emboli and dilated cardiomyopathy. His past medical history included a history of emergency laparotomy, splenectomy, and splenic flexure resection following a gunshot injury 3…
View article: Implant Surface Technologies to Promote Spinal Fusion: A Narrative Review
Implant Surface Technologies to Promote Spinal Fusion: A Narrative Review Open
The technology surrounding spinal fusion surgery has continuously evolved in tandem with advancements made in bioengineering. Over the past several decades, developments in biomechanics, surgical techniques, and materials science have expa…
View article: Intraoperative Fluorescence Imaging During Robotic Pancreatoduodenectomy to Detect Suture-Induced Hypoperfusion of the Pancreatic Stump as a Predictor of Postoperative Pancreatic Fistula (FLUOPAN): Prospective Proof-of-concept Study
Intraoperative Fluorescence Imaging During Robotic Pancreatoduodenectomy to Detect Suture-Induced Hypoperfusion of the Pancreatic Stump as a Predictor of Postoperative Pancreatic Fistula (FLUOPAN): Prospective Proof-of-concept Study Open
Background: A potential downside of robotic pancreatoduodenectomy (RPD) is the lack of tactile feedback when tying sutures, which could be especially perilous during pancreatic anastomosis. Near-infrared fluorescence imaging with indocyani…
View article: 1202 In vivo engineering of CAR T cells using a novel targeted LNP-mRNA technology
1202 In vivo engineering of CAR T cells using a novel targeted LNP-mRNA technology Open
Background Autologous chimeric antigen receptor (CAR) T cell therapies have revolutionized the treatment of some cancers and are now demonstrating effects in autoimmune disease. With several approved therapies on the market and cure rates …
View article: Artificial Intelligence to Preoperatively Predict Proximal Junction Kyphosis Following Adult Spinal Deformity Surgery: Soft Tissue Imaging May Be Necessary for Accurate Models
Artificial Intelligence to Preoperatively Predict Proximal Junction Kyphosis Following Adult Spinal Deformity Surgery: Soft Tissue Imaging May Be Necessary for Accurate Models Open
Study Design. Retrospective cohort. Objective: In a cohort of patients undergoing adult spinal deformity (ASD) surgery, we used artificial intelligence to compare three models of preoperatively predicting radiographic proximal junction kyp…
View article: The importance of Hounsfield units in adult spinal deformity surgery: finding an optimal threshold to minimize the risk of mechanical complications
The importance of Hounsfield units in adult spinal deformity surgery: finding an optimal threshold to minimize the risk of mechanical complications Open
Though several factors contribute to PJK, it appears that 163 HU may serve as a preliminary threshold when planning ASD surgery to mitigate the risk of PJK.
View article: Supplementary Figure 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Supplementary Figure 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
PDF file - 271K
View article: Supplementary Figure 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Supplementary Figure 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
PDF file - 271K
View article: Supplementary Figure Legends 1-2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Supplementary Figure Legends 1-2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
PDF file - 51K
View article: Supplementary Figure Legends 1-2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Supplementary Figure Legends 1-2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
PDF file - 51K
View article: Supplementary Figure 1 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Supplementary Figure 1 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
PDF file - 278K
View article: Supplementary Table 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Supplementary Table 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
PDF file - 73K
View article: Supplementary Table 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Supplementary Table 2 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
PDF file - 73K
View article: Data from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Data from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
Deregulation of the phosphoinositide 3-kinase (PI3K) signaling pathway such as by PTEN loss or PIK3CA mutation occurs frequently in human cancer and contributes to resistance to antitumor therapies. Inhibition of key signaling prote…
View article: Supplementary Figure 1 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Supplementary Figure 1 from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
PDF file - 278K
View article: Data from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity
Data from PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity Open
Deregulation of the phosphoinositide 3-kinase (PI3K) signaling pathway such as by PTEN loss or PIK3CA mutation occurs frequently in human cancer and contributes to resistance to antitumor therapies. Inhibition of key signaling prote…
View article: Clinical Prediction Models for Recurrence in Patients with Resectable Grade 1 and 2 Sporadic Non-Functional Pancreatic Neuroendocrine Tumors: A Systematic Review
Clinical Prediction Models for Recurrence in Patients with Resectable Grade 1 and 2 Sporadic Non-Functional Pancreatic Neuroendocrine Tumors: A Systematic Review Open
Recurrence after resection in patients with non-functional pancreatic neuroendocrine tumors (NF-pNET) has a considerable impact on overall survival. Accurate risk stratification will tailor optimal follow-up strategies. This systematic rev…