Explanipedia

Challenges and best practices when using ComBAT to harmonize diffusion MRI data Open

Félix Dumais, Jean-Christophe Houde, Leslie M. Shaw, Arthur W Toga, Laurel Beckett , et al. · 2025

Over the years, ComBAT has become the standard method for harmonizing MRI-derived measurements, with its ability to compensate for site-related additive and multiplicative biases while preserving biological variability. However, ComBAT rel…

Substantial Falls Increase Concern About Falling: a 12-Month Longitudinal Cohort Study Running title: Understanding the Development of Concerns About Falling in Older Adults Open

Mira Eileen Unverzagt, Kimberley S. van Schooten, Christopher McCrum, Jacqueline Close, Henry Brodaty , et al. · 2025

Background: Concern about falling (CaF) is common in older adults and predict falls, disability and loss of independence. However, it is unclear whether CaF is relatively stable or whether new falls contribute to increased CaF over time. T…

Combining CSF MTBR‐tau243 and plasma pTau217 ratio enhances the prediction of continuous regional tau PET burden in early Alzheimer's disease Open

Viswanath Devanarayan, Kanta Horie, Kristin R. Wildsmith, T. Doherty, Erica Andreozzi , et al. · 2025

INTRODUCTION Tau PET informs Alzheimer's disease (AD) staging but is limited by cost and access. Plasma phosphorylated‐to‐nonphosphorylated tau217 ratio (pTau217R) predicts amyloid and tau positron emission tomography (PET), while cerebros…

DWI-Positive Lesions in Acute Intracerebral Hemorrhage and Their Correlation With Small Vessel Disease Open

Satoshi Hosoki, Tomotaka Tanaka, Yuki I. Kawamura, Sonu Bhaskar, Soshiro Ogata , et al. · 2025

DWI-positive lesions are observed before blood pressure lowering, and their frequency increases over time. Their association with SVD markers highlights the role of advanced SVD in lesion formation. These lesions may worsen clinical outcom…

Network of positive affect and depression in older adults Open

Ella G. Hopkins, Patrick J. Leman, Matti Cervin, Katya Numbers, Henry Brodaty , et al. · 2025

Associations between volumes of grey matter regions and white matter hyperintensities with cognitive empathy in oldest-old adults Open

Russell J. Chander, Sarah A. Grainger, John D. Crawford, Jiyang Jiang, Nicole A. Kochan , et al. · 2025

OBJECTIVES To study the differential associations of regional volumes of grey matter (GM) and white matter hyperintensities (WMH) with behavioural and informant-reported measures of cognitive empathy (CE), especially in brain regions under…

Identification of circular RNAs associated with ageing of the dorsolateral prefrontal cortex across the adult lifespan Open

Fatemeh Amjadi‐Moheb, Sumangali Gobhidharan, Adith Mohan, Perminder S. Sachdev, Anbupalam Thalamuthu , et al. · 2025

Circular RNAs (circRNAs) are emerging as crucial regulators of biological processes and have been implicated in age-related diseases. Few studies have explored age-related circRNA expression in the human brain across the adult lifespan. Th…

Self-rated health and mortality: family background and genetic precursors Open

Brian Karl Finch, Deborah Finkel, Margaret Gatz, Nancy L. Pedersen, Chandra A. Reynolds , et al. · 2025

YI8 Characteristics of cognitive super-agers using different measurement approaches Open

Alice Powell, Peter Humburg, Jacqueline Close, Perminder S. Sachdev, Henry Brodaty · 2025

Intrinsic Capacity Predictors of Dementia and Mortality in the Sydney Memory and Ageing Study Open

Katya Numbers, Suraj Samtani, Katja Hanewald, J Cheung, Perminder S. Sachdev , et al. · 2025

Background Intrinsic Capacity (IC) is a developing concept focussed on promoting healthy ageing by maintaining functional abilities. It has been proposed as a better predictor of outcomes like dementia and mortality, compared to traditiona…

3538 Clinical profile of CADASIL: a preliminary case series from AusCADASIL Open

Danit Saks, Perminder S. Sachdev, AusCADASILStudy Team · 2025

Making time for brain health: recognising temporal inequity in dementia risk reduction Open

Susanne Röhr, Simone Reppermund, Annabel Matison, Suraj Samtani, Perminder S. Sachdev · 2025

Time is an under-recognised social determinant of brain health, and is potentially as important as education or income for dementia risk. Temporal inequity refers to the unequal distribution of discretionary time owing to structural condit…

How well do social frailty indices predict incident dementia in older adults? Open

Annabel P. Matison, Suraj Samtani, Henry Brodaty, Perminder S. Sachdev, Simone Reppermund · 2025

Objectives Few studies have examined the association between social frailty and dementia. We aim to assess if social frailty indices predict dementia and evaluate causality. Methods Data from 851 community-dwelling participants aged 70 yea…

Poor dream recall associates with Alzheimer’s disease biomarkers and dementia risk Open

Darren M. Lipnicki, Meritxell Valentí, Elizabeth Valeriano-Lorenzo, Ashleigh S. Vella, María Ascensión Zea‐Sevilla , et al. · 2025

INTRODUCTION Dreaming is subserved by the default mode network (DMN) and can be abolished by focal lesions within key regions. DMN dysfunction is promoted by pre-clinical Alzheimer’s pathology and apolipoprotein E ( APOE ) ε4 carriage, but…

Living in urban areas with highly interconnected streets is linked to greater posterior hippocampal volume in older adults Open

Govinda Poudel, Perminder S. Sachdev, Maria V. Soloveva, Miguel Molina, Ralf‐Dieter Schroers , et al. · 2025

Urban living exposes older adults to complex, interconnected environments. Street intersection density, an indicator of urban connectivity, has been linked to greater environmental engagement and wayfinding—both of which are important for …

Do associations of neighbourhood attributes with cognitive function vary by socio-economic status? A 12-year follow-up study of older Australians Open

Ester Cerin, Maria V. Soloveva, Miguel Alvarado Molina, Ralf‐Dieter Schroers, Yu‐Tzu Wu , et al. · 2025

Socio-economic status (SES), neighbourhood environments and their interactions can influence cognitive health in late life. Studies on this topic have examined a limited number of SES and environmental indicators and are mostly cross-secti…

Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals Open

J. Matthijs Biesbroek, Floor A.S. de Kort, Devasuda Anblagan, Mark E. Bastin, Alexa S. Beiser , et al. · 2025

BACKGROUND: White matter hyperintensities (WMHs) of presumed vascular origin are common in the elderly and are associated with vascular risk factors. There is evidence that vascular risk factors, in particular hypertension, are associated …

Is educational attainment protective against developing dementia? A twin study of genetic and environmental contributions Open

Ellen E. Walters, Susan E. Luczak, Christopher R. Beam, Malin Ericsson, William S. Kremen , et al. · 2025

Low educational attainment is recognized as a modifiable risk factor for dementia. Despite the commonly accepted notion that greater educational attainment confers lower dementia risk, few family-based studies have investigated the causal …

Neighborhood environments and transition to cognitive states: Sydney Memory and Ageing Study Open

Ester Cerin, Annabel P. Matison, Miguel Alvarado Molina, Ralf‐Dieter Schroers, Wei Li , et al. · 2025

INTRODUCTION Features of the neighborhood environment and ambient air pollution have been associated with onset and progression of neurocognitive disorders, but data from longitudinal population‐based studies are limited. METHODS One thous…

Does Ideal Blood Pressure Vary by Cognitive Domain? A UK Biobank Study Open

Matthew J. Lennon, Jan Willem van Dalen, Jessica Lo, Anbupalam Thalamuthu, John D. Crawford , et al. · 2025

High blood pressure (BP) is a risk factor for cognitive decline. Increasingly, studies have found the relationship to be nonlinear, with low BP also indicating higher risk. This UK Biobank study examines the nonlinear relationships between…

Risk and protective factors of healthy cognitive ageing across diverse global cohorts and causal effect of education Open

Heidi Johansen‐Berg, Bonnie Lam, Vincent Mok, Henry Brodaty, Yuan Cai , et al. · 2025

The global rise in cognitive impairment calls for preventive strategies through early identification of risk and protective factors in the community healthy elderlies that take into account cultural and geographic diversity. This study inv…

Self-Perceptions of Aging Mediate the Associations of 12-Year Change in Depressive Symptoms With Life Satisfaction and Disability Open

Serena Sabatini, Katya Numbers, Nicole A. Kochan, Perminder S. Sachdev, Henry Brodaty · 2025

Background This study estimates the associations of 12-year change in depressive symptoms with follow-up Self-Perceptions of Aging (SPAs), life satisfaction, and disability; and tests whether SPAs mediate the associations of change in depr…

Addressing global diversity in dementia research with the COSMIC collaboration Open

Darren M. Lipnicki, Ashleigh S. Vella, Jiyang Jiang, Louise Mewton, Annabel P. Matison , et al. · 2025

There is a need to study dementia risk factors more equitably across high-income countries (HICs) and low- and middle-income countries (LMICs). Cohort Studies of Memory in an International Consortium (COSMIC) is doing this by bringing toge…

Terminal Increases in Depressive Symptoms in a Multinational Twin Consortium Open

Andrew J. Petkus, Chandra A. Reynolds, Vibeke S. Catts, Kaare Christensen, Deborah Finkel , et al. · 2025

In later older adulthood, individuals report increased depressive symptoms, whereas gender differences in depressive symptoms narrow. We evaluated whether terminal decline (i.e., accelerated worsening in proximity to death) explained these…

Levels and changes in cognitive, mental, and physical health as correlates of attitudes to aging in very old age Open

Serena Sabatini, Katya Numbers, Nicole A. Kochan, Perminder S. Sachdev, Henry Brodaty · 2025

Introduction Studies investigating the associations between change in health indicators and multidimensional measures of self-perceptions of aging in very old age are scarce. This study investigated whether levels of and 12-year changes in…

Emotional and instrumental social support and older adults’ depressive symptoms: collaborative individual participant data meta-analysis of 11 population-based studies of aging Open

Suraj Samtani, Gowsaly Mahalingam, Ben C. P. Lam, Darren M. Lipnicki, Katya Numbers , et al. · 2025

Social support is considered a protective factor against depression, but there are inconsistent findings regarding social support and depression in older adults. We aimed to clarify the association between emotional and instrumental social…

Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes Open

Elham Assary, Jonathan R. I. Coleman, Gibran Hemani, Margot P. van de Weijer, Laurence J Howe , et al. · 2025

Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging to detect. Geno…

Apathy is distinct from depression or fatigue and is associated with poor physical health in an older community cohort Open

Fleur Harrison, Moyra E. Mortby, Andrew R. Lloyd, Adam J. Guastella, Julian N. Trollor , et al. · 2025

Apathy is more common than depression or fatigue in dementia-free older adults. It does not typically co-occur with these symptoms, but is accompanied by poorer physical health, including multimorbidity and metabolic dysregulation. Apathy …

Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology Open

Ana Isabel Silva, Ida E. Sønderby, George Kirov, Abdel Abdellaoui, Ingrid Agartz , et al. · 2025

Our findings link global and regional cortical morphometric features with CNV penetrance, providing new insights into neurobiological mechanisms of genetic risk for schizophrenia and other developmental disorders.

Patterns of neuropsychological deficits and memory profile in ischaemic stroke subtypes in an Asian cohort Open

Nicole Yun Ching Chen, Hui Tan, Jing Xu, Bernard Poon Lap Chan, Narayanaswamy Venketasubramanian , et al. · 2025

Due to the heterogenous nature of stroke, cognitive impairments differ widely across subtypes. This study explored neuropsychological patterns and memory profiles of Asian patients with different ischaemic stroke subtypes. Participants inc…

Perminder S. Sachdev YOU? Author Swipe