Jeffrey E. Arle
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View article: The Asymptotic Intelligence Thesis: Rethinking the Ceiling of AGI Cognition
The Asymptotic Intelligence Thesis: Rethinking the Ceiling of AGI Cognition Open
Is there an upper limit to "intelligence"? While investigations of intelligence date back at least to the 1950s, this fundamental question has never been answered. We recount key points of the history of artificial intelligence, which offe…
View article: Technical nuance of ventriculoperitoneal shunt placement in a patient with cutis verticis gyrata: illustrative case
Technical nuance of ventriculoperitoneal shunt placement in a patient with cutis verticis gyrata: illustrative case Open
BACKGROUND Cutis verticis gyrata (CVG) is a rare benign scalp condition that causes the formation of skin ridges and furrows. Because of the altered scalp anatomy, this condition can pose unique challenges in neurosurgical procedures. OBSE…
View article: Closing the loop and raising the bar: Automated control systems in neuromodulation
Closing the loop and raising the bar: Automated control systems in neuromodulation Open
Introduction Neuromodulation has emerged as a promising therapy for the management of chronic pain, movement disorders, and other neurological conditions. Spinal cord stimulation (SCS) is a widely used form of neuromodulation that involves…
View article: Glossary of Neurostimulation Terminology: A Collaborative Neuromodulation Foundation, Institute of Neuromodulation, and International Neuromodulation Society Project
Glossary of Neurostimulation Terminology: A Collaborative Neuromodulation Foundation, Institute of Neuromodulation, and International Neuromodulation Society Project Open
Although we refer to the glossary presented herein as the print edition, it can of course be viewed and searched electronically. NF, IoN, and INS will continue to collaborate on expanded web editions that can include hyperlinks for interna…
View article: Computational Modelling of Deep Brain Stimulation for Parkinson's Disease: A Critical Review
Computational Modelling of Deep Brain Stimulation for Parkinson's Disease: A Critical Review Open
We review the use of numerical and computational models to explore deep brain stimulation for Parkinson’s disease (DBS PD). It is a review for the modeler and those interested in PD DBS modelling methods and their value. The main model cat…
View article: RBIO-04. NEW THERAPEUTIC DELIVERY METHODS FOR TUMOR-TREATING FIELDS FOR HIGHER EFFICACY
RBIO-04. NEW THERAPEUTIC DELIVERY METHODS FOR TUMOR-TREATING FIELDS FOR HIGHER EFFICACY Open
Tumor-treating fields (TTFields) are the fourth modality of glioblastoma (GBM) treatment and in conjunction with chemotherapy can increase overall survival of GBM patients up to 60 months. However, in vitro and in animal models TTFields sh…
View article: Thirty-Day Outcomes From Standalone Minimally Invasive Surgery-Transforaminal Lumbar Interbody Fusion Patients in an Ambulatory Surgery Center vs. Hospital Setting
Thirty-Day Outcomes From Standalone Minimally Invasive Surgery-Transforaminal Lumbar Interbody Fusion Patients in an Ambulatory Surgery Center vs. Hospital Setting Open
View article: Robustness in Neural Circuits
Robustness in Neural Circuits Open
Complex systems are found everywhere – from scheduling to traffic, food to climate, economics to ecology, the brain, and the universe. Complex systems typically have many elements, many modes of interconnectedness of those elements, and of…
View article: Functional Requirements of Small- and Large-Scale Neural Circuitry Connectome Models
Functional Requirements of Small- and Large-Scale Neural Circuitry Connectome Models Open
We have truly entered the Age of the Connectome due to a confluence of advanced imaging tools, methods such as the flavors of functional connectivity analysis and inter-species connectivity comparisons, and computational power to simulate …
View article: Non-invasive trial testing for trigeminal branch stimulation to treat refractory trigeminal neuropathic pain: A technical note
Non-invasive trial testing for trigeminal branch stimulation to treat refractory trigeminal neuropathic pain: A technical note Open
Objective: Trigeminal neuropathic pain can be debilitating and extremely difficult to treat. Trigeminal branch stimulation is a minimally invasive treatment that has shown benefit in earlier series. However, there is currently no widely ac…
View article: SCIDOT-52. IN SITU DELIVERY OF TUMOR TREATING FIELDS THERAPY IN GLIOBLASTOMA PATIENTS
SCIDOT-52. IN SITU DELIVERY OF TUMOR TREATING FIELDS THERAPY IN GLIOBLASTOMA PATIENTS Open
The efficacy of Tumor-Treating Fields (TTFields) rests on the result of a large-scale clinical trial that demonstrated an increase in the survival of newly diagnosed glioblastoma patients when combined with temozolomide chemotherapy. Overa…
View article: Bidirectional modulation of human emotional conflict resolution using intracranial stimulation
Bidirectional modulation of human emotional conflict resolution using intracranial stimulation Open
The ability to regulate emotions in the service of meeting ongoing goals and task demands is a key aspect of adaptive human behavior in our volatile social world. Consequently, difficulties in processing and responding to emotional stimuli…
View article: Safety and Efficacy of the VariLift-C® Cervical Standalone Interbody Fusion Device with Emphasis on Multiple-level and Prior Fusion Cases
Safety and Efficacy of the VariLift-C® Cervical Standalone Interbody Fusion Device with Emphasis on Multiple-level and Prior Fusion Cases Open
Introduction The VariLift-C® is a stand-alone, expandable, cervical interbody fusion device, not requiring the addition of anterior plating. Because of the access and placement technique, as well as not needing a plate, the devi…
View article: Neuromonitoring for Spinal Cord Stimulation Lead Placement Under General Anesthesia
Neuromonitoring for Spinal Cord Stimulation Lead Placement Under General Anesthesia Open
Spinal cord stimulation (SCS) is a common therapeutic technique for treating medically refractory neuropathic back and other limb pain syndromes. SCS has historically been performed using a sedative anesthetic technique where the patient i…
View article: Factors predicting reoperation of chronic subdural hematoma following primary surgical evacuation
Factors predicting reoperation of chronic subdural hematoma following primary surgical evacuation Open
OBJECTIVE Chronic subdural hematoma (CSDH) is commonly encountered in neurosurgical practice. However, surgical evacuation remains complicated by a high rate of reoperation. The optimal surgical approach to reduce the reoperation rate has …
View article: Occipital Nerve Stimulation for the Treatment of Patients With Medically Refractory Occipital Neuralgia
Occipital Nerve Stimulation for the Treatment of Patients With Medically Refractory Occipital Neuralgia Open
BACKGROUND: Occipital neuralgia (ON) is a disorder characterized by sharp, electrical, paroxysmal pain, originating from the occiput and extending along the posterior scalp, in the distribution of the greater, lesser, and/or third occipita…