Jeffrey E. Max
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View article: Interactions between mild traumatic brain injury and genetics perturb neuronal and glial pathways and networks relevant to learning and memory in ABCD study
Interactions between mild traumatic brain injury and genetics perturb neuronal and glial pathways and networks relevant to learning and memory in ABCD study Open
Mild traumatic brain injury (mTBI) disproportionately affects children and adolescents and has been associated with poorer neurocognitive performance, but the variability in acute and chronic symptoms presents challenges in understanding t…
View article: Examining putamen resting-state connectivity markers of suicide attempt history in depressed adolescents
Examining putamen resting-state connectivity markers of suicide attempt history in depressed adolescents Open
Introduction Suicide is a current leading cause of death in adolescents and young adults. The neurobiological underpinnings of suicide risk in youth, however, remain unclear and a brain-based model is lacking. In adult samples, current mod…
View article: Traumatic brain injury, working memory-related neural processing, and alcohol experimentation behaviors in youth from the ABCD cohort
Traumatic brain injury, working memory-related neural processing, and alcohol experimentation behaviors in youth from the ABCD cohort Open
Adolescent traumatic brain injury (TBI) has long-term effects on brain functioning and behavior, impacting neural activity under cognitive load, especially in the reward network. Adolescent TBI is also linked to risk-taking behaviors inclu…
View article: Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury
Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury Open
Importance Traumatic brain injury (TBI) is known to cause widespread neural disruption in the cerebrum. However, less is known about the association of TBI with cerebellar structure and how such changes may alter executive functioning. Obj…
View article: A Systematic Review of MRI Studies and the “Emotional paiN and social Disconnect (END)” Brain Model of Suicidal Behavior in Youth
A Systematic Review of MRI Studies and the “Emotional paiN and social Disconnect (END)” Brain Model of Suicidal Behavior in Youth Open
Introduction. Risk of suicidal ideation and suicidal behaviors greatly increases during adolescence, and rates have risen dramatically over the past two decades. However, few risk factors or biomarkers predictive of suicidal ideation or at…
View article: Linking Symptom Inventories using Semantic Textual Similarity
Linking Symptom Inventories using Semantic Textual Similarity Open
An extensive library of symptom inventories has been developed over time to measure clinical symptoms, but this variety has led to several long standing issues. Most notably, results drawn from different settings and studies are not compar…
View article: Novel Oppositional Defiant Disorder or Conduct Disorder 24 Months After Traumatic Brain Injury in Children and Adolescents
Novel Oppositional Defiant Disorder or Conduct Disorder 24 Months After Traumatic Brain Injury in Children and Adolescents Open
Approximately 14% of children with TBI developed oppositional defiant disorder or conduct disorder. The risk for novel oppositional defiant disorder or conduct disorder can be understood from a biopsychosocial perspective. Sex differences …
View article: Assessing Pediatric Mild Traumatic Brain Injury and Its Recovery Using Resting-State Magnetoencephalography Source Magnitude Imaging and Machine Learning
Assessing Pediatric Mild Traumatic Brain Injury and Its Recovery Using Resting-State Magnetoencephalography Source Magnitude Imaging and Machine Learning Open
The objectives of this machine-learning (ML) resting-state magnetoencephalography (rs-MEG) study involving children with mild traumatic brain injury (mTBI) and orthopedic injury (OI) controls were to define a neural injury signature of mTB…
View article: Multimodal Analysis of Secondary Cerebellar Alterations after Pediatric Traumatic Brain Injury
Multimodal Analysis of Secondary Cerebellar Alterations after Pediatric Traumatic Brain Injury Open
While traditionally ignored as a region purely responsible for motor function, the cerebellum is increasingly being appreciated for its contributions to higher order functions through various cerebro-cerebellar networks. Traumatic brain in…
View article: A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma
A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma Open
Introduction Childhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of whole brain voxel-based morphometry (VBM) correlates of childhood …
View article: Resting state brain subnetwork relates to prosociality and compassion in adolescents
Resting state brain subnetwork relates to prosociality and compassion in adolescents Open
Adolescence is a crucial time for social development, especially for helping (prosocial) and compassionate behaviors; yet brain networks involved in adolescent prosociality and compassion currently remain underexplored. Here, we sought to …
View article: Novel Psychiatric Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents
Novel Psychiatric Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents Open
The results demonstrate that occurrence of novel psychiatric disorders following pediatric TBI requiring hospitalization is common and has identifiable psychosocial and specific biological predictors. However, only the lesion predictors we…
View article: Novel Oppositional Defiant Disorder 12 Months After Traumatic Brain Injury in Children and Adolescents
Novel Oppositional Defiant Disorder 12 Months After Traumatic Brain Injury in Children and Adolescents Open
These results demonstrate that novel oppositional defiant disorder following TBI selectively and negatively affects an identifiable group of children. Both proximal (preinjury adaptive function) and distal (socioeconomic status and psychos…
View article: Novel Oppositional Defiant Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents
Novel Oppositional Defiant Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents Open
These findings show that an important minority of children with TBI developed ODD. Psychosocial and injury-related variables, including socioeconomic status, lower family function, psychosocial adversity, and processing speed, significantl…
View article: Three-Month Psychiatric Outcome of Pediatric Mild Traumatic Brain Injury: A Controlled Study
Three-Month Psychiatric Outcome of Pediatric Mild Traumatic Brain Injury: A Controlled Study Open
The objective was to clarify occurrence, phenomenology, and risk factors for novel psychiatric disorder (NPD) in the first 3 months after mild traumatic brain injury (mTBI) and orthopedic injury (OI). Children aged 8-15 years with mTBI (n …
View article: Traumatic Brain Injury in Children and Adolescents: Psychiatric Disorders 24 Years Later
Traumatic Brain Injury in Children and Adolescents: Psychiatric Disorders 24 Years Later Open
Long-term psychiatric outcome (mean=23.92 years [SD=2.17]) in children and adolescents hospitalized for TBI can be predicted at the point of the initial hospitalization encounter by the presence of a preinjury psychiatric disorder and by g…
View article: Advances in Understanding the Association Between Pediatric Traumatic Brain Injury and Attention-Deficit/Hyperactivity Disorder
Advances in Understanding the Association Between Pediatric Traumatic Brain Injury and Attention-Deficit/Hyperactivity Disorder Open
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA J…
View article: White Matter Disruption in Pediatric Traumatic Brain Injury
White Matter Disruption in Pediatric Traumatic Brain Injury Open
WM disruption after msTBI is widespread, persistent, and influenced by demographic and clinical variables. Future work will test techniques for harmonizing neurocognitive data, enabling more advanced analyses to identify symptom clusters a…
View article: Long-Term Psychiatric Outcomes in Adults with History of Pediatric Traumatic Brain Injury
Long-Term Psychiatric Outcomes in Adults with History of Pediatric Traumatic Brain Injury Open
The objective of the study was to compare psychiatric outcomes in adults with and without history of pediatric traumatic brain injury (TBI). Youth ages 6 to 14 years hospitalized for TBI from 1992 to 1994 were assessed at baseline and at 3…
View article: Neural Correlates of Smartphone Dependence in Adolescents
Neural Correlates of Smartphone Dependence in Adolescents Open
Increases in depressive and suicide-related symptoms among United States adolescents have been recently linked to increased use of smartphones. Understanding of the brain mechanisms that underlie the potential smartphone dependence may hel…
View article: White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric msTBI
White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric msTBI Open
Annually, approximately 3 million children around the world experience traumatic brain injuries (TBIs), of which up to 20% are characterized as moderate to severe (msTBI) and/or have abnormal imaging findings. Affected children are vulnera…
View article: Resting-State Magnetoencephalography Source Imaging Pilot Study in Children with Mild Traumatic Brain Injury
Resting-State Magnetoencephalography Source Imaging Pilot Study in Children with Mild Traumatic Brain Injury Open
Mild traumatic brain injury (mTBI) accounts for the vast majority of all pediatric TBI. An important minority of children who have suffered an mTBI have enduring cognitive and emotional symptoms. However, the mechanisms of chronic symptoms…
View article: Challenges and Opportunities for Neuroimaging in Young Patients with Traumatic Brain Injury: a Coordinated Effort towards Advancing Discovery from the ENIGMA Pediatric Moderate/Severe TBI Group
Challenges and Opportunities for Neuroimaging in Young Patients with Traumatic Brain Injury: a Coordinated Effort towards Advancing Discovery from the ENIGMA Pediatric Moderate/Severe TBI Group Open
Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population; however, research in this po…
View article: Structural Neuroimaging Findings in Mild Traumatic Brain Injury
Structural Neuroimaging Findings in Mild Traumatic Brain Injury Open
Common neuroimaging findings in mild traumatic brain injury (mTBI), including sport-related concussion (SRC), are reviewed based on computed tomography and magnetic resonance imaging (MRI). Common abnormalities radiologically identified on…
View article: Concussion and Psychiatric Outcome in Adults and Children
Concussion and Psychiatric Outcome in Adults and Children Open
I accepted the invitation to write this editorial on the traumatic brain injury (TBI) manuscripts in this edition of the Journal because of my career focus on psychiatric aspects of TBI. I disclose that I am also privileged to be a contrib…
View article: A Systematic Review of Psychiatric, Psychological, and Behavioural Outcomes following Mild Traumatic Brain Injury in Children and Adolescents
A Systematic Review of Psychiatric, Psychological, and Behavioural Outcomes following Mild Traumatic Brain Injury in Children and Adolescents Open
Background: Evidence regarding longer-term psychiatric, psychological, and behavioural outcomes (for example, anxiety, mood disorders, depression, and attention disorders) following mild traumatic brain injury (mTBI) in children and adoles…