Jeffrey F. Quinn
YOU?
Author Swipe
View article: A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration
A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration Open
Tissue regeneration requires precise activation and coordination of genes, many of which are reused from development. Although key factors have been identified, how their expression is initiated and spatially regulated after injury remains…
View article: A Bayesian active learning platform for scalable combination drug screens
A Bayesian active learning platform for scalable combination drug screens Open
Large-scale combination drug screens are generally considered intractable due to the immense number of possible combinations. Existing approaches use ad hoc fixed experimental designs then train machine learning models to impute unobserved…
View article: A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration
A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration Open
Tissue regeneration requires precise activation and coordination of genes, many of which are reused from development. While key factors have been identified, how their expression is initiated and spatially regulated after injury remains un…
View article: A Bayesian active learning platform for scalable combination drug screens
A Bayesian active learning platform for scalable combination drug screens Open
Large-scale combination drug screens are generally considered intractable due to the immense number of possible combinations. Existing approaches use ad hoc fixed experimental designs then train machine learning models to impute novel comb…
View article: BayesTME: A unified statistical framework for spatial transcriptomics
BayesTME: A unified statistical framework for spatial transcriptomics Open
Spatial variation in cellular phenotypes underlies heterogeneity in immune recognition and response to therapy in cancer and many other diseases. Spatial transcriptomics (ST) holds the potential to quantify such variation, but existing ana…