Jeffrey H. Samet
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View article: Sex differences in beneficial and pathogenic bacteria in People With HIV (PWH) with a history of heavy alcohol drinking
Sex differences in beneficial and pathogenic bacteria in People With HIV (PWH) with a history of heavy alcohol drinking Open
Background HIV-1 infection and hazardous levels of alcohol consumption have been independently linked to gut dysbiosis affecting beneficial butyrate-producing bacteria. However, sex-based differences in the composition and function of gut …
View article: Gabapentin to achieve HIV viral load suppression in people with risky drinking in Mbarara, Uganda: study protocol for a randomized, double-blinded, placebo-controlled trial (GRAIL)
Gabapentin to achieve HIV viral load suppression in people with risky drinking in Mbarara, Uganda: study protocol for a randomized, double-blinded, placebo-controlled trial (GRAIL) Open
Background:Ending the HIV epidemic requires achieving HIV viral load (HVL) suppression for key populations including those with risky drinking. Gabapentin can decrease alcohol use and thus holds potential for improving medication adherence…
View article: Creation of a telehealth addiction consultation service at a rural hospital: a case study
Creation of a telehealth addiction consultation service at a rural hospital: a case study Open
Background Rural communities face significant barriers to accessing substance use disorder (SUD) treatment, resulting in gaps in care and increased rates of opioid-related overdose deaths. Hospital-based Addiction Consult Services (ACS) im…
View article: Alcohol interventions for persons with HIV: Meta-analysis of randomized controlled trials using phosphatidylethanol and self-report
Alcohol interventions for persons with HIV: Meta-analysis of randomized controlled trials using phosphatidylethanol and self-report Open
Results confirm prior findings of significant efficacy of alcohol interventions for PWH. Effect sizes were small across measurements, while heterogeneity was high when using self-report alone. Combined PEth/self-report is a useful primary …
View article: The Process and Cost of Developing a Community Advisory Board Focused on Opioid Overdose Deaths
The Process and Cost of Developing a Community Advisory Board Focused on Opioid Overdose Deaths Open
Background: We describe the Community Advisory Board (CAB) development and costing processes employed by The Helping to End Addiction Long-term (HEALing) Communities Study, Massachusetts (HCS-MA). The actual process and costs associated wi…
View article: High-Dose Buprenorphine Treatment in the Setting of Fentanyl
High-Dose Buprenorphine Treatment in the Setting of Fentanyl Open
Importance The emergence of fentanyl in the setting of the US opioid crisis demands reconsideration of clinical approaches to buprenorphine initiation for patients with opioid use disorder (OUD), with the rationale that fentanyl’s unique p…
View article: Impact of hepatitis C serostatus on health service utilization for opioid-related harms among individuals prescribed opioid agonist therapy: A longitudinal prospective cohort study
Impact of hepatitis C serostatus on health service utilization for opioid-related harms among individuals prescribed opioid agonist therapy: A longitudinal prospective cohort study Open
View article: Effects of the Communities That HEAL intervention on initiation, retention, and linkage to medications for opioid use disorder (MOUD): A cluster randomized wait-list controlled trial
Effects of the Communities That HEAL intervention on initiation, retention, and linkage to medications for opioid use disorder (MOUD): A cluster randomized wait-list controlled trial Open
Medications for opioid use disorder (MOUD) can reduce opioid use and overdose deaths. This study examined whether the Communities That HEAL (CTH) intervention increased MOUD initiation, retention, and linkage. The HEALing Communities Study…
View article: Aligning Efforts to Boost Medications for Opioid Use Disorder and Pre-Exposure Prophylaxis for HIV
Aligning Efforts to Boost Medications for Opioid Use Disorder and Pre-Exposure Prophylaxis for HIV Open
View article: Do Communities Implementing the Communities That HEAL Intervention Have Significantly Lower Rates of High-Risk Opioid Prescribing and Dispensing?
Do Communities Implementing the Communities That HEAL Intervention Have Significantly Lower Rates of High-Risk Opioid Prescribing and Dispensing? Open
View article: Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use Disorder
Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use Disorder Open
Importance Alcohol use disorder (AUD) is common in hospital patients. AUD medications are not typically initiated in that setting. The comparative effectiveness between initiation of oral naltrexone and extended-release injectable naltrexo…
View article: “Every Time I Go in There, It Gives Me Time to Reflect”: A Qualitative Study of Patient Perspectives on Substance Use, Medications for Opioid Use Disorder, and Harm Reduction Following Hospitalization for Serious Injection-Related Infection
“Every Time I Go in There, It Gives Me Time to Reflect”: A Qualitative Study of Patient Perspectives on Substance Use, Medications for Opioid Use Disorder, and Harm Reduction Following Hospitalization for Serious Injection-Related Infection Open
Background Serious injection-related infections (SIRIs) have high morbidity and mortality, in part from incomplete antibiotic treatment, ongoing substance use and reinfection. Understanding how hospitalizations for SIRIs affect patient per…
View article: Opioid Use Disorder Medications Among Youth in Primary Care: Subgroup Analysis of the PROUD Trial
Opioid Use Disorder Medications Among Youth in Primary Care: Subgroup Analysis of the PROUD Trial Open
OBJECTIVE Medications for opioid use disorder (OUD) are underused among adolescents and young adults (“youth”). Offering buprenorphine or naltrexone in primary care settings may reduce barriers to their use among youth. We conducted a seco…
View article: Is There an Association Between Cigarette Smoking and Advanced Liver Fibrosis in Smokers with HIV, Heavy Drinking and High Prevalence of HCV?
Is There an Association Between Cigarette Smoking and Advanced Liver Fibrosis in Smokers with HIV, Heavy Drinking and High Prevalence of HCV? Open
Background: Cigarette smoking has been associated with liver fibrosis in the setting of hepatitis C virus (HCV) infection but has not been studied among people with HIV (PWH) who consume alcohol. Methods: This is a cross-sectional study of…
View article: mHealth Incentivized Adherence Plus Patient Navigation (MIAPP): protocol for a pilot randomized controlled trial to improve linkage and retention on buprenorphine for hospitalized patients with methamphetamine use and opioid use disorder
mHealth Incentivized Adherence Plus Patient Navigation (MIAPP): protocol for a pilot randomized controlled trial to improve linkage and retention on buprenorphine for hospitalized patients with methamphetamine use and opioid use disorder Open
Background Initiation of buprenorphine for treatment of opioid use disorder (OUD) in acute care settings improves access and outcomes, however patients who use methamphetamine are less likely to link to ongoing treatment. We describe the i…
View article: Stigma and efficacy beliefs regarding opioid use disorder treatment and naloxone in communities participating in the HEALing Communities Study intervention
Stigma and efficacy beliefs regarding opioid use disorder treatment and naloxone in communities participating in the HEALing Communities Study intervention Open
Background The HEALing Communities Study (HCS) included health campaigns as part of a community-engaged intervention to reduce opioid-related overdose deaths in 67 highly impacted communities across Kentucky, Massachusetts, New York, and O…
View article: Nurse Care Management of Opioid Use Disorder Treatment After 3 Years
Nurse Care Management of Opioid Use Disorder Treatment After 3 Years Open
Importance The Primary Care Opioid Use Disorders (PROUD) treatment trial was a 2-year implementation trial that demonstrated the Massachusetts office-based addiction treatment (OBAT) model of nurse care management for opioid use disorder (…
View article: Opioid risk-reduction strategies for people with HIV on chronic opioid therapy: A qualitative study of patient perspectives
Opioid risk-reduction strategies for people with HIV on chronic opioid therapy: A qualitative study of patient perspectives Open
View article: Communities That HEAL Intervention and Mortality Including Polysubstance Overdose Deaths
Communities That HEAL Intervention and Mortality Including Polysubstance Overdose Deaths Open
Importance The HEALing Communities Study (HCS) evaluated the effectiveness of the Communities That HEAL (CTH) intervention in preventing fatal overdoses amidst the US opioid epidemic. Objective To evaluate the impact of the CTH interventio…
View article: Post‐legalization shifts in cannabis use among young adults in Georgia—A nationally representative study
Post‐legalization shifts in cannabis use among young adults in Georgia—A nationally representative study Open
Background and aim In 2018, the country of Georgia legalized cannabis for recreational use and decriminalized limited possession. This study aimed to assess whether cannabis use increased among young adults (ages 18–29 years) in Georgia af…
View article: Effect of the Communities That HEAL Intervention on Overdose Education and Naloxone Distribution: A Cluster-Randomized, Wait-List Controlled Trial
Effect of the Communities That HEAL Intervention on Overdose Education and Naloxone Distribution: A Cluster-Randomized, Wait-List Controlled Trial Open
Objectives. To determine whether the Communities That HEAL (CTH) intervention is effective in increasing naloxone distribution compared with usual care. Methods. The HEALing (Helping to End Addiction Long-Term) Communities Study (HCS) is a…
View article: Addiction Science & Clinical Practice: a new partnership with the Grayken Center for Addiction at Boston Medical Center to usher in our next phase
Addiction Science & Clinical Practice: a new partnership with the Grayken Center for Addiction at Boston Medical Center to usher in our next phase Open
View article: Medication for Opioid Use Disorder After Serious Injection-Related Infections in Massachusetts
Medication for Opioid Use Disorder After Serious Injection-Related Infections in Massachusetts Open
Importance Serious injection-related infections (SIRIs) cause significant morbidity and mortality. Medication for opioid use disorder (MOUD) improves outcomes but is underused. Understanding MOUD treatment after SIRIs could inform interven…
View article: PrEP facilitators and barriers in substance use bridge clinics for women who engage in sex work and who use drugs
PrEP facilitators and barriers in substance use bridge clinics for women who engage in sex work and who use drugs Open
Background Women who engage in sex work and use drugs (WSWUD) experience disproportionate HIV risks. Substance use treatment bridge clinics offer an opportunity to increase HIV pre-exposure prophylaxis (PrEP) delivery to WSWUD, but researc…
View article: Socioeconomic Status and CD4 Count Among People with HIV Who Inject Drugs in St. Petersburg, Russia
Socioeconomic Status and CD4 Count Among People with HIV Who Inject Drugs in St. Petersburg, Russia Open
View article: Effect of the Communities that HEAL intervention on receipt of behavioral therapies for opioid use disorder: A cluster randomized wait-list controlled trial
Effect of the Communities that HEAL intervention on receipt of behavioral therapies for opioid use disorder: A cluster randomized wait-list controlled trial Open
View article: Pilot RCT comparing low-dose naltrexone, gabapentin and placebo to reduce pain among people with HIV with alcohol problems
Pilot RCT comparing low-dose naltrexone, gabapentin and placebo to reduce pain among people with HIV with alcohol problems Open
Background To estimate the effects on pain of two medications (low-dose naltrexone and gabapentin) compared to placebo among people with HIV (PWH) with heavy alcohol use and chronic pain. Methods We conducted a pilot, randomized, double-bl…
View article: Impact of the Communities That HEAL Intervention on Buprenorphine-Waivered Practitioners and Buprenorphine Prescribing
Impact of the Communities That HEAL Intervention on Buprenorphine-Waivered Practitioners and Buprenorphine Prescribing Open
Importance Buprenorphine significantly reduces opioid-related overdose mortality. From 2002 to 2022, the Drug Addiction Treatment Act of 2000 (DATA 2000) required qualified practitioners to receive a waiver from the Drug Enforcement Agency…
View article: Comparative costs and potential affordability of a multifaceted intervention to improve treatment outcomes among people with HIV who inject drugs in Russia: economic evaluation of the LINC‐II randomized controlled trial
Comparative costs and potential affordability of a multifaceted intervention to improve treatment outcomes among people with HIV who inject drugs in Russia: economic evaluation of the LINC‐II randomized controlled trial Open
Introduction The LINC‐II randomized controlled trial in St. Petersburg, Russia for HIV‐positive adults who inject drugs found that a multi‐component intervention including initiation of antiretroviral therapy (ART) during admission to an a…
View article: Cannabis Use Legalization and its Impact on Emerging Adults in Georgia – A Nationally-Representative Survey Study
Cannabis Use Legalization and its Impact on Emerging Adults in Georgia – A Nationally-Representative Survey Study Open