Jeffrey M. Long
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View article: Spike-wave discharges are uncoupled with cognitive outcome in aged Long-Evans rats
Spike-wave discharges are uncoupled with cognitive outcome in aged Long-Evans rats Open
Rational Rodent EEGs display 7–12 Hz oscillations called spike-wave discharges (SWDs) that are more abundant with age, and some data suggest that they might interfere with hippocampus-dependent memory processing. Objective To test whether …
View article: Constructing and Implementing a Low-Cost On-Demand Morris Water Maze Platform
Constructing and Implementing a Low-Cost On-Demand Morris Water Maze Platform Open
The Morris water maze (MWM) is one of the most widely used procedures to assess hippocampus-dependent spatial learning and memory in rodents. By varying test protocols, researchers can test several different domains of learning and memory.…
View article: The Huntington’s Disease Integrated Staging System
The Huntington’s Disease Integrated Staging System Open
The Huntington’s Disease Integrated Staging System (HD‐ISS) comprises a biological research definition of HD and evidence‐based staging centered on prognostic biological, clinical, and functional landmarks. It is the result of a formal con…
View article: Mitochondrial respiratory capacity is not altered in aging rat brains with or without memory impairment
Mitochondrial respiratory capacity is not altered in aging rat brains with or without memory impairment Open
Mitochondria are essential for supporting the high metabolic demands that are required for brain function. Impairments in mitochondria have been linked to age-related decline in brain functions. Here, we investigate whether the mitochondri…
View article: Cerebellum Purkinje cell vulnerability in aged rats with memory impairment
Cerebellum Purkinje cell vulnerability in aged rats with memory impairment Open
The cerebellum is involved in higher order cognitive function and is susceptible to age‐related atrophy. However, limited evidence has directly examined the cerebellum's role in cognitive aging. To interrogate potential substrates of the r…
View article: Cognitive performance is associated with cardiovascular and renal remodeling in young female rats with chronic kidney disease
Cognitive performance is associated with cardiovascular and renal remodeling in young female rats with chronic kidney disease Open
Background The prevalence of cognitive impairment (CI) and dementia in end‐stage chronic kidney disease (CKD) has been estimated at 30‐60%. Cardiovascular dysfunction accompanies CKD and contributes to CI in humans and animal models. Since…
View article: Chronic kidney disease is associated with cognitive dysfunction and cardiovascular remodeling in aged male and female Sprague‐Dawley rats
Chronic kidney disease is associated with cognitive dysfunction and cardiovascular remodeling in aged male and female Sprague‐Dawley rats Open
Background Cardiovascular diseases (CVD), including increased central arterial stiffness (CAS), accompany chronic kidney disease (CKD) development. An increase in pulse wave velocity (PWV), an index for CAS, is implicated in age‐associated…
View article: Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation Open
Introduction Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used to study and treat sever…
View article: Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed
Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed Open
Basal forebrain (BF) projections to the hippocampus and cortex are anatomically positioned to influence a broad range of cognitive capacities that are known to decline in normal aging, including executive function and memory. Although a lo…
View article: Treatment with losartan, an AT1 receptor blocker, improves cognitive and cardiovascular function in a Dahl salt‐sensitive rat model of age‐associated vascular dementia.
Treatment with losartan, an AT1 receptor blocker, improves cognitive and cardiovascular function in a Dahl salt‐sensitive rat model of age‐associated vascular dementia. Open
Background Dementia is characterized by progressive cognitive impairment (CI), which is accompanied by decline in reasoning, planning and memory. Cardiovascular diseases are the major contributors to the pathogenesis of vascular dementia a…
View article: Effect of Cardiotonic Steroid Marinobufagenin on Vascular Remodeling and Cognitive Impairment in Young Dahl-S Rats
Effect of Cardiotonic Steroid Marinobufagenin on Vascular Remodeling and Cognitive Impairment in Young Dahl-S Rats Open
The hypertensive response in Dahl salt-sensitive (DSS) rats on a high-salt (HS) diet is accompanied by central arterial stiffening (CAS), a risk factor for dementia, and heightened levels of a prohypertensive and profibrotic factor, the en…
View article: Differential Retinoic Acid Signaling in the Hippocampus of Aged Rats with and without Memory Impairment
Differential Retinoic Acid Signaling in the Hippocampus of Aged Rats with and without Memory Impairment Open
Retinoic acid (RA), a metabolite of vitamin A, has many physiological functions, and mounting evidence points to important roles in cognition. In vitro experiments indicate that RA is involved in homeostatic synaptic scaling in the hippoca…
View article: Loss of Sensitivity to Rewards by Dopamine Neurons May Underlie Age-Related Increased Probability Discounting
Loss of Sensitivity to Rewards by Dopamine Neurons May Underlie Age-Related Increased Probability Discounting Open
Normative aging is known to affect how decisions are made in risky situations. Although important individual variability exists, on average, aging is accompanied by greater risk aversion. Here the behavioral and neural mechanisms of greate…
View article: Transcranial Magnetic Stimulation in Alzheimer’s Disease: Are We Ready?
Transcranial Magnetic Stimulation in Alzheimer’s Disease: Are We Ready? Open
Transcranial magnetic stimulation (TMS) is among a growing family of noninvasive brain stimulation techniques being developed to treat multiple neurocognitive disorders, including Alzheimer’s disease (AD). Although small clinical trials in…
View article: HDAC3-Mediated Repression of the <i>Nr4a</i> Family Contributes to Age-Related Impairments in Long-Term Memory
HDAC3-Mediated Repression of the <i>Nr4a</i> Family Contributes to Age-Related Impairments in Long-Term Memory Open
Aging is accompanied by cognitive deficits, including impairments in long-term memory formation. Understanding the molecular mechanisms that support preserved cognitive function in aged animals is a critical step toward identifying novel t…
View article: Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats
Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats Open
Significance Neural network dynamics thought to play a key role in cognition are substantially disrupted in both normal and pathological aging. Using a rat model, here we aimed to define the effects of aging on the integrity of cortical re…
View article: Mesolimbic neuropeptide W coordinates stress responses under novel environments
Mesolimbic neuropeptide W coordinates stress responses under novel environments Open
Significance The study proposes a physiological role for neuropeptide W (NPW) in modulating mouse behaviors under stress. We found that NPW-producing neurons (which are a small subset of mesolimbic dopaminergic neurons) exclusively innerva…