Jeffrey P. Guenette
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View article: Integration of Trackerless Surface Reconstruction‐Based Surgical Navigation With Exoscopic Trans‐Mastoid Surgery
Integration of Trackerless Surface Reconstruction‐Based Surgical Navigation With Exoscopic Trans‐Mastoid Surgery Open
Objective A trackerless approach to surgical navigation employing simultaneous localization and mapping (SLAM) algorithms based on surface reconstruction from 3D endoscopy fused with preoperative imaging has been demonstrated to have appro…
View article: Patient-reported symptom relief from percutaneous benign thyroid nodule radiofrequency ablation in routine clinical care
Patient-reported symptom relief from percutaneous benign thyroid nodule radiofrequency ablation in routine clinical care Open
RFA＝ radiofrequency ablation; BTN＝ benign thyroid nodule; VAS＝ visual analog scale; VRR＝ volume reduction ratio; TSH = thyroid stimulating hormone; LA＝ laser ablation; MWA＝ microwave ablation.
View article: Artificial Intelligence Measured Tumor Burden and Pre‐Treatment Circulating Tumor <scp>DNA</scp> in Human Papilloma Virus‐Associated Oropharynx Cancer
Artificial Intelligence Measured Tumor Burden and Pre‐Treatment Circulating Tumor <span>DNA</span> in Human Papilloma Virus‐Associated Oropharynx Cancer Open
Background Artificial intelligence (AI)‐based imaging analysis and circulating tumor‐associated DNA (ctDNA) are both being used diagnostically in HPV‐driven oropharynx squamous cell carcinoma (HPV‐OPSCC). We evaluated associations between …
View article: Figure S3 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Figure S3 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Eligible and completed plasma TTMV tests at each study time point
View article: Figure S2 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Figure S2 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Histogram of tests per patient
View article: Figure S1 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Figure S1 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Study schema
View article: Data from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Data from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Purpose:Observational studies suggest circulating tumor human papillomavirus (HPV) DNA may facilitate early detection of recurrent HPV-positive oropharynx cancer. We prospectively investigated whether biomarker-guided surveillance detects …
View article: Table S3 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Table S3 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Test performance metrics for total study population
View article: Table S2 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Table S2 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Clinical evaluations performed after detectable surveillance TTMV until diagnosis of recurrence for early true-positive subjects
View article: Table S4 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Table S4 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Test performance metrics for subjects with baseline detectable TTMV and HPV16
View article: Table S1 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Table S1 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Number of subjects eligible for and with completed TTMV testing at each study time point
View article: Table S6 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Table S6 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Representativeness of study participants
View article: Table S5 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
Table S5 from A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA Open
Test performance metrics for subjects with baseline TTMV>200 and HPV16
View article: International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation
International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation Open
Background Pathologic extranodal extension (pENE) is a crucial prognostic factor in oropharyngeal cancer (OPC), but determining pENE from imaging has high inter‐observer variability. The role of clinician specialty in the accuracy of imagi…
View article: The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study
The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study Open
Introduction The rapid growth in popularity of e-cigarettes over the past decade has prompted concerns about their impact on long-term respiratory health. Small airway injury is suspected to be a direct consequence of e-cigarette use and m…
View article: Systematic Review of the Diagnostic Imaging Evaluation of Pulsatile Tinnitus
Systematic Review of the Diagnostic Imaging Evaluation of Pulsatile Tinnitus Open
Objective Aggregate published data on the imaging of pulsatile tinnitus as a step toward building a framework for an evidence-based approach to diagnostic imaging for this symptom. Materials & Methods A systematic review was performed. PUB…
View article: Frequently Asked Questions on Imaging in Chimeric Antigen Receptor T-Cell Therapy Clinical Trials
Frequently Asked Questions on Imaging in Chimeric Antigen Receptor T-Cell Therapy Clinical Trials Open
Clinical trials for chimeric antigen receptor (CAR) T-cell therapy are in the early stages but are expected to progress alongside new treatment approaches. This suggests that imaging will play an important role in monitoring disease progre…
View article: Incidence of immune effector cell-associated neurotoxicity among patients treated with CAR T-cell therapy for hematologic malignancies: systematic review and meta-analysis
Incidence of immune effector cell-associated neurotoxicity among patients treated with CAR T-cell therapy for hematologic malignancies: systematic review and meta-analysis Open
Objectives We aim to assess the pooled incidence of immune effector cell-associated neurotoxicity syndrome (ICANS) in clinical trials and real-world studies of chimeric antigen receptor (CAR) T-cell therapy for hematologic malignancy and c…
View article: Asthma coexistence does not worsen or accelerate the decline in exercise capacity in COPD
Asthma coexistence does not worsen or accelerate the decline in exercise capacity in COPD Open
Despite worse clinical and patient-reported outcomes, older adults with asthma-COPD coexistence do not have more severely impaired nor a faster rate of decline in exercise capacity compared to those with COPD alone https://bit.ly/3B…
View article: A Public Health Perspective on Radiologists’ Interpretation Volumes
A Public Health Perspective on Radiologists’ Interpretation Volumes Open
In the recent AJNR study by Ivanovic et al,[1][1] interpretation volume is associated with diagnostic error at the time of interpretation, presumably in the form of a missed diagnosis or misdiagnosis. The actual error rates may be even hig…
View article: Registration of longitudinal spine CTs for monitoring lesion growth
Registration of longitudinal spine CTs for monitoring lesion growth Open
Accurate and reliable registration of longitudinal spine images is essential for assessment of disease progression and surgical outcome. Implementing a fully automatic and robust registration is crucial for clinical use, however, it is cha…
View article: Improved optic nerve visualization and treatment planning through a dedicated optic nerve MRI protocol
Improved optic nerve visualization and treatment planning through a dedicated optic nerve MRI protocol Open
OBJECTIVE This study describes an innovative optic nerve MRI protocol for better delineating optic nerve anatomy from neighboring pathology. METHODS Twenty-two patients undergoing MRI examination of the optic nerve with the dedicated proto…
View article: Time-Saving 3D MR Imaging Protocols with Millimeter and Submillimeter Isotropic Spatial Resolution for Face and Neck Imaging as Implemented at a Single-Site Major Referral Center
Time-Saving 3D MR Imaging Protocols with Millimeter and Submillimeter Isotropic Spatial Resolution for Face and Neck Imaging as Implemented at a Single-Site Major Referral Center Open
MR imaging has become the routine technique for staging nasopharyngeal carcinoma, evaluating perineural tumor spread, and detecting cartilage invasion in laryngeal carcinoma. However, these protocols traditionally require in the range of 2…
View article: Registration of Longitudinal Spine CTs for Monitoring Lesion Growth
Registration of Longitudinal Spine CTs for Monitoring Lesion Growth Open
Accurate and reliable registration of longitudinal spine images is essential for assessment of disease progression and surgical outcome. Implementing a fully automatic and robust registration is crucial for clinical use, however, it is cha…
View article: Time-Saving 3D MR Imaging Protocols with Millimeter and Submillimeter Isotropic Spatial Resolution for Face and Neck Imaging as Implemented at a Single-Site Major Referral Center
Time-Saving 3D MR Imaging Protocols with Millimeter and Submillimeter Isotropic Spatial Resolution for Face and Neck Imaging as Implemented at a Single-Site Major Referral Center Open
MR imaging has become the routine technique for staging nasopharyngeal carcinoma, evaluating perineural tumor spread, and detecting cartilage invasion in laryngeal carcinoma. However, these protocols traditionally require in the range of 2…
View article: Inner Ear Breaches from Vestibular Schwannoma Surgery: Revisiting the Incidence of Otologic Injury from Retrosigmoid and Middle Cranial Fossa Approaches
Inner Ear Breaches from Vestibular Schwannoma Surgery: Revisiting the Incidence of Otologic Injury from Retrosigmoid and Middle Cranial Fossa Approaches Open
Objective To assess the rate of iatrogenic injury to the inner ear in vestibular schwannoma resections. Study Design Retrospective case review Setting Multiple academic tertiary care hospitals. Patients Patients who underwent retrosigmoid …
View article: Actionability of Recommendations for Additional Imaging in Head and Neck Radiology
Actionability of Recommendations for Additional Imaging in Head and Neck Radiology Open
View article: NIMG-52. CORRELATION OF BIDIMENSIONAL AND VOLUMETRIC TUMOR SIZING IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA
NIMG-52. CORRELATION OF BIDIMENSIONAL AND VOLUMETRIC TUMOR SIZING IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA Open
BACKGROUND Glioblastoma (GBM) is the most common malignant primary nervous system tumor and remains incurable with a poor prognosis despite current therapy. The standard for monitoring response to treatment, as defined by the Response Asse…
View article: Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium
Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium Open
View article: Fluorodeoxyglucose-avid cosmetic poly-L-lactic acid filler on surveillance imaging for Merkel cell carcinoma
Fluorodeoxyglucose-avid cosmetic poly-L-lactic acid filler on surveillance imaging for Merkel cell carcinoma Open