Jeffrey R. Leonard
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View article: PEDIA-BRAIN: A single nuclei multiomic encyclopedia of the human pons provides a resource for normal development and disease vulnerability
PEDIA-BRAIN: A single nuclei multiomic encyclopedia of the human pons provides a resource for normal development and disease vulnerability Open
The human pons relays sensory and motor information between the brain and the body. It is a key site for pathological processes, including diffuse midline gliomas (DMGs) and multiple sclerosis (MS) which predominantly arise in childhood an…
View article: Ultra-low-field portable MRI for assessing ventricular size in pediatric hydrocephalus: a feasibility study
Ultra-low-field portable MRI for assessing ventricular size in pediatric hydrocephalus: a feasibility study Open
OBJECTIVE Hydrocephalus, characterized by abnormal CSF accumulation, poses diagnostic and management challenges, especially in pediatric patients. Timely and accurate diagnosis is crucial for effective treatment. The aim of this study was …
View article: Postoperative outcomes and stimulation responses for sectioned nerve roots during selective dorsal rhizotomy in cerebral palsy
Postoperative outcomes and stimulation responses for sectioned nerve roots during selective dorsal rhizotomy in cerebral palsy Open
Background Cerebral palsy (CP) is the most cause of motor dysfunction in children. Selective dorsal rhizotomy (SDR) plays a major role in long term spasticity control. However, limited data exists on the effect of SDR on postoperative spas…
View article: Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy
Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy Open
View article: HGG-44. BRAINSTEM HIGH-GRADE ASTROCYTOMA WITH PILOID FEATURES (HGAP) WITH AN NTRK FUSION: A HISTOLOGICAL MIMICKER AND RARE PEDIATRIC BRAIN TUMOR
HGG-44. BRAINSTEM HIGH-GRADE ASTROCYTOMA WITH PILOID FEATURES (HGAP) WITH AN NTRK FUSION: A HISTOLOGICAL MIMICKER AND RARE PEDIATRIC BRAIN TUMOR Open
BACKGROUND HGAP is a recently defined rare glial neoplasm, whose classification requires pathognomonic epigenetic signatures. HGAP can arise anywhere within the central nervous system but most have been reported in the cerebellum (74%). Ra…
View article: PECARN prediction rule for cervical spine imaging of children presenting to the emergency department with blunt trauma: a multicentre prospective observational study
PECARN prediction rule for cervical spine imaging of children presenting to the emergency department with blunt trauma: a multicentre prospective observational study Open
View article: The role of occipital condyle and atlas anomalies on occipital cervical fusion outcomes in Chiari malformation type I with syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium
The role of occipital condyle and atlas anomalies on occipital cervical fusion outcomes in Chiari malformation type I with syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium Open
OBJECTIVE Congenital anomalies of the atlanto-occipital articulation may be present in patients with Chiari malformation type I (CM-I). However, it is unclear how these anomalies affect the biomechanical stability of the craniovertebral ju…
View article: Unraveling the complexity of the senescence-associated secretory phenotype in adamantinomatous craniopharyngioma using multimodal machine learning analysis
Unraveling the complexity of the senescence-associated secretory phenotype in adamantinomatous craniopharyngioma using multimodal machine learning analysis Open
Background Cellular senescence can have positive and negative effects on the body, including aiding in damage repair and facilitating tumor growth. Adamantinomatous craniopharyngioma (ACP), the most common pediatric sellar/suprasellar brai…
View article: Full-length isoform concatenation sequencing to resolve cancer transcriptome complexity
Full-length isoform concatenation sequencing to resolve cancer transcriptome complexity Open
Background Cancers exhibit complex transcriptomes with aberrant splicing that induces isoform-level differential expression compared to non-diseased tissues. Transcriptomic profiling using short-read sequencing has utility in providing a c…
View article: Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy
Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy Open
View article: Table of Contents
Table of Contents Open
View article: Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution
Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution Open
Oncolytic viruses, modified for tumor-restricted infection, are a promising cancer immunotherapeutic, yet much remains to be understood about factors driving their activity and outcome in the tumor microenvironment. Here, we report that on…
View article: DIPG-52. EXTRAPONTINE PROGRESSION WITH STABLE PONTINE DISEASE POST-RADIOTHERAPY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) ON A CONNECT TRIAL: IMPLICATIONS FOR RADIATION TREATMENT VOLUMES
DIPG-52. EXTRAPONTINE PROGRESSION WITH STABLE PONTINE DISEASE POST-RADIOTHERAPY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) ON A CONNECT TRIAL: IMPLICATIONS FOR RADIATION TREATMENT VOLUMES Open
Radiotherapy remains the only treatment modality proven to prolong survival and alleviate symptom burden for patients with DIPG. Upfront focal photon radiation to 54 Gy with 1-1.5cm margins is standard. Subventricular, leptomeningeal, and/…
View article: LGG-14. TREATMENT OF TWO PEDIATRIC FGFR-ALTERED LOW-GRADE GLIONEURONAL TUMORS WITH MEK INHIBITION
LGG-14. TREATMENT OF TWO PEDIATRIC FGFR-ALTERED LOW-GRADE GLIONEURONAL TUMORS WITH MEK INHIBITION Open
Somatic alterations in the fibroblast growth factor receptor (FGFR) gene family (FGFR1/2/3) have been implicated in tumorigenesis across pediatric low-grade glioneuronal neoplasms and represent a potential therapeutic target. FGFR rearrang…
View article: DIPG-54. UPDATED FINDINGS FROM THE PHASE IB STUDY OF UNESBULIN (PTC596) IN CHILDREN WITH NEWLY-DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND HIGH-GRADE GLIOMA (HGG): A REPORT FROM THE COLLABORATIVE NETWORK FOR NEURO-ONCOLOGY CLINICAL TRIALS (CONNECT)
DIPG-54. UPDATED FINDINGS FROM THE PHASE IB STUDY OF UNESBULIN (PTC596) IN CHILDREN WITH NEWLY-DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND HIGH-GRADE GLIOMA (HGG): A REPORT FROM THE COLLABORATIVE NETWORK FOR NEURO-ONCOLOGY CLINICAL TRIALS (CONNECT) Open
BMI-1 represents a potential therapeutic target in pediatric HGG given its role in self-renewal and DNA-damage signaling, high expression levels in these tumors, and resultant proliferation blockade, mitotic abnormalities, and radiosensiti…
View article: Supplementary Figure 2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Supplementary Figure 2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Supplementary Figure 2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
View article: Data from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Data from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Pilocytic astrocytomas (PAs) are the most common glioma in children. Whereas many PAs are slow-growing or clinically indolent, others exhibit more aggressive features with tumor recurrence and death. To identify genetic signatures that mig…
View article: Data from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Data from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Pilocytic astrocytomas (PAs) are the most common glioma in children. Whereas many PAs are slow-growing or clinically indolent, others exhibit more aggressive features with tumor recurrence and death. To identify genetic signatures that mig…
View article: Supplementary Figure Legends 1-2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Supplementary Figure Legends 1-2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Supplementary Figure Legends 1-2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
View article: Supplementary Figure 2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Supplementary Figure 2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Supplementary Figure 2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
View article: Supplementary Table 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Supplementary Table 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Supplementary Table 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
View article: Supplementary Figure 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Supplementary Figure 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Supplementary Figure 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
View article: Supplementary Table 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Supplementary Table 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Supplementary Table 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
View article: Supplementary Figure 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Supplementary Figure 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Supplementary Figure 1 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
View article: Supplementary Figure Legends 1-2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
Supplementary Figure Legends 1-2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin Open
Supplementary Figure Legends 1-2 from Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region Origin
View article: A Cervical Spine Injury Prediction Rule for Children after Blunt Trauma
A Cervical Spine Injury Prediction Rule for Children after Blunt Trauma Open
View article: Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis
Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis Open
Rasmussen encephalitis (RE) is a rare childhood neurological disease characterized by progressive unilateral loss of function, hemispheric atrophy and drug-resistant epilepsy. Affected brain tissue shows signs of infiltrating cytotoxic T-c…
View article: 1135 Single cell resolution of immune responses to oncolytic herpes simplex virus C134 in preclinical medulloblastoma models
1135 Single cell resolution of immune responses to oncolytic herpes simplex virus C134 in preclinical medulloblastoma models Open
Background Medulloblastoma is the most common malignant brain tumor in children.1 Despite recent advances in our understanding of its tumor biology, one-third of affected children do not survive this disease. Even amongst surviv…
View article: Association between synthetic sealants and increased complication rates in posterior fossa decompression with duraplasty for Chiari malformations regardless of graft type
Association between synthetic sealants and increased complication rates in posterior fossa decompression with duraplasty for Chiari malformations regardless of graft type Open
OBJECTIVE Dural sealants are commonly used in posterior fossa decompression with duraplasty (PFDD) for Chiari malformation type I (CMI). Prior evidence suggests that combining certain sealants with some graft material is associated with an…
View article: Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement
Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement Open
Rhabdoid tumors (RTs) of the brain (atypical teratoid/rhabdoid tumor; AT/RT) and extracranial sites (most often the kidney; RTK) are malignant tumors predominantly occurring in children, frequently those with SMARCB1 germline alterations. …