Jeffrey S. Rush
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View article: A conserved glycan motif overcomes antigenic variation inducing broadly reactive antibodies against the zoonotic pathogen<i>Streptococcus suis</i>
A conserved glycan motif overcomes antigenic variation inducing broadly reactive antibodies against the zoonotic pathogen<i>Streptococcus suis</i> Open
Streptococcus suis is a largely neglected but emerging bacterial zoonotic pathogen of global concern for animal welfare, antibiotic resistance development and human health. No effective vaccines are currently available. Here, we identified…
View article: Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci
Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci Open
Proteins harboring intrinsically disordered regions (IDRs) lacking stable secondary or tertiary structures are abundant across the three domains of life. These regions have not been systematically studied in prokaryotes. Here, our genome-w…
View article: Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide
Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide Open
Streptococcus mutans , the causative agent of human dental caries, expresses a cell wall attached Serotype c- specific Carbohydrate (SCC) that is critical for cell viability. SCC consists of a polyrhamnose backbone of →3)α-Rha(1 → 2)α-Rha(…
View article: Structure and mechanism of biosynthesis of<i>Streptococcus mutans</i>cell wall polysaccharide
Structure and mechanism of biosynthesis of<i>Streptococcus mutans</i>cell wall polysaccharide Open
Streptococcus mutans, the causative agent of human dental caries, expresses a cell wall attached Serotype c- specific Carbohydrate (SCC) that is critical for cell viability. SCC consists of a repeating →3)α-Rha(1→2)α-Rha(1→ polyrhamnose ba…
View article: Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci
Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci Open
Proteins harboring intrinsically disordered regions (IDRs) lacking stable secondary or tertiary structures are abundant across the three domains of life. These regions have not been systematically studied in prokaryotes. Our genome-wide an…
View article: PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides
PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides Open
View article: PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides
PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides Open
The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC). GAC is a promising target for the development of GAS vaccines. In this study, emp…
View article: Modification of cell wall polysaccharide guides cell division in Streptococcus mutans
Modification of cell wall polysaccharide guides cell division in Streptococcus mutans Open
View article: Modification of cell wall polysaccharide spatially controls cell division in<i>Streptococcus mutans</i>
Modification of cell wall polysaccharide spatially controls cell division in<i>Streptococcus mutans</i> Open
Bacterial cell division is driven by a tubulin homolog FtsZ, which assembles into the Z-ring structure leading to the recruitment of the cell division machinery. In ovoid-shaped Gram-positive bacteria, such as streptococci, MapZ guides Z-r…
View article: Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides
Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides Open
View article: The <i>Mycobacterium tuberculosis</i> Pup-proteasome system regulates nitrate metabolism through an essential protein quality control pathway
The <i>Mycobacterium tuberculosis</i> Pup-proteasome system regulates nitrate metabolism through an essential protein quality control pathway Open
Significance The proteasome is required for the full virulence of Mycobacterium tuberculosis . However, the extent of its role as a regulator of bacterial physiology remains unclear. In this work, we demonstrate a function of the proteasom…
View article: The<i>Mycobacterium tuberculosis</i>Pup-proteasome system regulates nitrate metabolism through an essential protein quality control system
The<i>Mycobacterium tuberculosis</i>Pup-proteasome system regulates nitrate metabolism through an essential protein quality control system Open
The human pathogen Mycobacterium tuberculosis ( M. tuberculosis ) encodes a proteasome that carries out regulated degradation of bacterial proteins. It has been proposed that the proteasome contributes to nitrogen metabolism in M. tubercul…
View article: Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides
Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides Open
Cell wall glycopolymers on the surface of Gram-positive bacteria are fundamental to bacterial physiology and infection biology. These structures have also gained interest as vaccine antigens, in particular for the human pathogens Group A S…
View article: The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A carbohydrate in Streptococcus pyogenes
The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A carbohydrate in Streptococcus pyogenes Open
View article: The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A Carbohydrate in<i>Streptococcus pyogenes</i>
The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A Carbohydrate in<i>Streptococcus pyogenes</i> Open
In many Lactobacillales species (i.e. lactic acid bacteria), peptidoglycan is decorated by polyrhamnose polysaccharides that are critical for cell envelope integrity and cell shape and also represent key antigenic determinants. Despite the…
View article: SpyB, a Small Heme-Binding Protein, Affects the Composition of the Cell Wall in Streptococcus pyogenes
SpyB, a Small Heme-Binding Protein, Affects the Composition of the Cell Wall in Streptococcus pyogenes Open
Streptococcus pyogenes (Group A Streptococcus or GAS) is a hemolytic human pathogen associated with a wide variety of infections ranging from minor skin and throat infections to life-threatening invasive diseases. The cell wa…
View article: Issue Information
Issue Information Open
View article: ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported Patients
ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported Patients Open
Congenital disorders of glycosylation (CDG) arise from pathogenic mutations in over 100 genes leading to impaired protein or lipid glycosylation. ALG1 encodes a β1,4 mannosyltransferase that catalyzes the addition of the first of nine mann…
View article: Role of Flippases in Protein Glycosylation in the Endoplasmic Reticulum
Role of Flippases in Protein Glycosylation in the Endoplasmic Reticulum Open
Glycosylation is essential to the synthesis, folding, and function of glycoproteins in eukaryotes. Proteins are co- and posttranslationally modified by a variety of glycans in the endoplasmic reticulum (ER); modifications include C- and O-…