Jeffrey V. Siebers
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View article: Clinical validation of myOSLchip: A beryllium oxide optically stimulated luminescent dosimeter (OSLD) system in radiotherapy dosimetry
Clinical validation of myOSLchip: A beryllium oxide optically stimulated luminescent dosimeter (OSLD) system in radiotherapy dosimetry Open
In radiation oncology, inter‐fractional dosimetry using optically stimulated luminescent detectors (OSLDs) ensures accurate plan delivery and patient safety. RadPro International GmbH's myOLSchip system, featuring a beryllium oxide (BeO) O…
View article: AAPM WGTG51 Report 385: Addendum to the AAPM's TG‐51 protocol for clinical reference dosimetry of high‐energy electron beams
AAPM WGTG51 Report 385: Addendum to the AAPM's TG‐51 protocol for clinical reference dosimetry of high‐energy electron beams Open
An Addendum to the AAPM's TG‐51 protocol for the determination of absorbed dose to water is presented for electron beams with energies between 4 MeV and 22 MeV (). This updated formalism allows simplified calibration procedures, including …
View article: Divergent Clinical Equivalence Findings from DVH and NTCP Metrics for Alternative OAR Delineations with Increasing Setup Variability in Head-and-Neck Radiotherapy
Divergent Clinical Equivalence Findings from DVH and NTCP Metrics for Alternative OAR Delineations with Increasing Setup Variability in Head-and-Neck Radiotherapy Open
Purpose: This study quantifies the variation in dose-volume histogram (DVH) and normal tissue complication probability (NTCP) metrics for head-and-neck (HN) cancer patients when alternative organ-at-risk (OAR) delineations are used for tre…
View article: OpenKBP-Opt: an international and reproducible evaluation of 76 knowledge-based planning pipelines
OpenKBP-Opt: an international and reproducible evaluation of 76 knowledge-based planning pipelines Open
Objective.To establish an open framework for developing plan optimization models for knowledge-based planning (KBP).Approach.Our framework includes radiotherapy treatment data (i.e. reference plans) for 100 patients with head-and-neck canc…
View article: OpenKBP-Opt: an international and reproducible evaluation of 76 knowledge-based planning pipelines
OpenKBP-Opt: an international and reproducible evaluation of 76 knowledge-based planning pipelines Open
Objective. To establish an open framework for developing plan optimization models for knowledge-based planning (KBP). Approach. Our framework includes radiotherapy treatment data (i.e. reference plans) for 100 patients with head-and-neck c…
View article: AAPM WGTG51 Report 374: Guidance for TG‐51 reference dosimetry
AAPM WGTG51 Report 374: Guidance for TG‐51 reference dosimetry Open
Practical guidelines that are not explicit in the TG‐51 protocol and its Addendum for photon beam dosimetry are presented for the implementation of the TG‐51 protocol for reference dosimetry of external high‐energy photon and electron beam…
View article: Gross patient error detection via cine transmission dosimetry
Gross patient error detection via cine transmission dosimetry Open
$\textbf{Purpose:}$ To quantify the effectiveness of EPID-based cine transmission dosimetry to detect gross patient anatomic errors. $\textbf{Method and Materials:}$ EPID image frames resulting from fluence transmitted through multiple pat…
View article: DeepDoseNet: A Deep Learning model for 3D Dose Prediction in Radiation\n Therapy
DeepDoseNet: A Deep Learning model for 3D Dose Prediction in Radiation\n Therapy Open
The DeepDoseNet 3D dose prediction model based on ResNet and Dilated DenseNet\nis proposed. The 340 head-and-neck datasets from the 2020 AAPM OpenKBP\nchallenge were utilized, with 200 for training, 40 for validation, and 100 for\ntesting.…
View article: DeepDoseNet: A Deep Learning model for 3D Dose Prediction in Radiation Therapy
DeepDoseNet: A Deep Learning model for 3D Dose Prediction in Radiation Therapy Open
The DeepDoseNet 3D dose prediction model based on ResNet and Dilated DenseNet is proposed. The 340 head-and-neck datasets from the 2020 AAPM OpenKBP challenge were utilized, with 200 for training, 40 for validation, and 100 for testing. St…
View article: OARnet: Automated organs-at-risk delineation in Head and Neck CT images
OARnet: Automated organs-at-risk delineation in Head and Neck CT images Open
A 3D deep learning model (OARnet) is developed and used to delineate 28 H&N OARs on CT images. OARnet utilizes a densely connected network to detect the OAR bounding-box, then delineates the OAR within the box. It reuses information from a…
View article: Dose escalation in the definite target volume
Dose escalation in the definite target volume Open
Purpose To introduce the definite target volume (DTV) and evaluate dosimetric consequences of boosting dose to this region of high clinical target volume (CTV)‐ and low organs at risk (OAR)‐probability. Methods This work defines the DTV vi…
View article: Beam modeling and beam model commissioning for Monte Carlo dose calculation‐based radiation therapy treatment planning: Report of AAPM Task Group 157
Beam modeling and beam model commissioning for Monte Carlo dose calculation‐based radiation therapy treatment planning: Report of AAPM Task Group 157 Open
Dose calculation plays an important role in the accuracy of radiotherapy treatment planning and beam delivery. The Monte Carlo (MC) method is capable of achieving the highest accuracy in radiotherapy dose calculation and has been implement…
View article: Quantifying the dosimetric impact of organ-at-risk delineation variability in head and neck radiation therapy in the context of patient setup uncertainty
Quantifying the dosimetric impact of organ-at-risk delineation variability in head and neck radiation therapy in the context of patient setup uncertainty Open
The purpose of this study was to quantify the potential dosimetric impact of delineation variability (DV) in head and neck radiation therapy (RT) when inherent patient setup variability (SV) is also considered. The impact of DV was assesse…
View article: Robust radiotherapy planning
Robust radiotherapy planning Open
Motion and uncertainty in radiotherapy is traditionally handled via margins. The clinical target volume (CTV) is expanded to a larger planning target volume (PTV), which is irradiated to the prescribed dose. However, the PTV concept has se…
View article: Quality assurance tool for organ at risk delineation in radiation therapy using a parametric statistical approach
Quality assurance tool for organ at risk delineation in radiation therapy using a parametric statistical approach Open
Purpose To develop a quality assurance ( QA ) tool that identifies inaccurate organ at risk ( OAR ) delineations. Methods The QA tool computed volumetric features from prior OAR delineation data from 73 thoracic patients to construct a ref…
View article: Beyond the margin recipe: the probability of correct target dosage and tumor control in the presence of a dose limiting structure
Beyond the margin recipe: the probability of correct target dosage and tumor control in the presence of a dose limiting structure Open
In the past, hypothetical spherical target volumes and ideally conformal dose distributions were analyzed to establish the safety of planning target volume (PTV) margins. In this work we extended these models to estimate how alternative me…
View article: Insight gained from responses to surveys on reference dosimetry practices
Insight gained from responses to surveys on reference dosimetry practices Open
Purpose To present the results and discuss potential insights gained through surveys on reference dosimetry practices. Methods Two surveys were sent to medical physicists to learn about the current state of reference dosimetry practices at…
View article: Clinical adequacy assessment of autocontours for prostate IMRT with meaningful endpoints
Clinical adequacy assessment of autocontours for prostate IMRT with meaningful endpoints Open
When including daily setup variations in prostate IMRT, the dose-volume metric CP, and biological indices of ROIs were approximately equivalent for the plans created based on manually drawn targets and autosegmented OARs in 88% of cases. T…
View article: A clinically observed discrepancy between image‐based and log‐based MLC positions
A clinically observed discrepancy between image‐based and log‐based MLC positions Open
Purpose: To present a clinical case in which real‐time intratreatment imaging identified an multileaf collimator (MLC) leaf to be consistently deviating from its programmed and logged position by >1 mm. Methods: An EPID‐based exit‐fluence …
View article: Benefits of adaptive radiation therapy in lung cancer as a function of replanning frequency
Benefits of adaptive radiation therapy in lung cancer as a function of replanning frequency Open
Purpose: To quantify the potential benefit associated with daily replanning in lung cancer in terms of normal tissue dose sparing and to characterize the tradeoff between adaptive benefit and replanning frequency. Methods: A set of synthet…
View article: A linear, separable two-parameter model for dual energy CT imaging of proton stopping power computation
A linear, separable two-parameter model for dual energy CT imaging of proton stopping power computation Open
The proton stopping power estimation accuracy of the proposed linear, separable BVM model is comparable to or better than that of the nonseparable tPFM models proposed by other groups. In contrast to the tPFM, the BVM does not require an i…