Jelena Bašić
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View article: Genetics of Frontotemporal Dementia in the Serbian Population: Findings from a Hospital-Based Cohort
Genetics of Frontotemporal Dementia in the Serbian Population: Findings from a Hospital-Based Cohort Open
Background and objectives: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder with autosomal dominant forms most often linked to MAPT, GRN, and C9orf72. We aimed to evaluate the prevalence of pathogenic variants in…
View article: Determination of Gingival Index and Salivary Proinflammatory Cytokines (Interleukin 6 and Tumour Necrosis Factor α) After Chemical–Mechanical Retraction Procedure
Determination of Gingival Index and Salivary Proinflammatory Cytokines (Interleukin 6 and Tumour Necrosis Factor α) After Chemical–Mechanical Retraction Procedure Open
Background and Objectives: The aim of this study was to test the impact of the gingival chemical–mechanical retraction procedure on the value of the gingival index (GI) and salivary concentrations of interleukin 6 (IL-6) and tumour necrosi…
View article: Multi-biomarker assessment of metal-oxide nanoparticle toxicity in Chironomus riparius
Multi-biomarker assessment of metal-oxide nanoparticle toxicity in Chironomus riparius Open
The increasing production and utilization of metal-oxide nanoparticles (NPs) such as titanium dioxide (TiO2), cerium dioxide (CeO2), and magnetite (Fe3O4) have raised concerns regarding their environmental impact. This study aimed to asses…
View article: Matrix Remodeling Enzymes as Potential Fluid Biomarkers of Neurodegeneration in Alzheimer’s Disease
Matrix Remodeling Enzymes as Potential Fluid Biomarkers of Neurodegeneration in Alzheimer’s Disease Open
This study investigated the diagnostic accuracy of plasma biomarkers—specifically, matrix metalloproteinase (MMP-9), tissue inhibitor of metalloproteinase (TIMP-1), CD147, and the MMP-/TIMP-1 ratio in patients with Alzheimer’s disease (AD)…
View article: THE INFLUENCE OF THE APOEε4 ALLELE ON PRO-INFLAMMATORY CYTOKINE LEVELS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH ALZHEIMER’S DISEASE
THE INFLUENCE OF THE APOEε4 ALLELE ON PRO-INFLAMMATORY CYTOKINE LEVELS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH ALZHEIMER’S DISEASE Open
Single nucleotide polymorphisms (SNPs) rs429358 and rs7412, the most commonly investigated variants in the apolipoprotein E gene (APOE) are crucial for APOEε4 carrier status determination. However, their association with inflammatory cytok…
View article: A connection between levels of soluble Fas and Fas ligand in the aqueous humor and the parameters of structural and functional damage of glaucoma patients
A connection between levels of soluble Fas and Fas ligand in the aqueous humor and the parameters of structural and functional damage of glaucoma patients Open
Introduction/Objective Fas ligand (FasL) induces apoptosis when interacting with the Fas-receptor. The aim was to determine the concentration of soluble Fas (sFas) and soluble FasL (sFasL) in the aqueous humor (AH) of open-angle glaucoma p…
View article: Increased concentration of tumour necrosis factor alpha in the plasma of glaucoma patients
Increased concentration of tumour necrosis factor alpha in the plasma of glaucoma patients Open
Background/Aim. Changes in the concentration of various mediators of inflammation in blood, aqueous humor, or eye tissues support the role of inflammation in the pathogenesis of open-angle glaucoma (OAG). Inflammatory biomarkers have a gre…
View article: Apolipoprotein E and matrix remodeling – a link to neurodegeneration in Alzheimer's disease
Apolipoprotein E and matrix remodeling – a link to neurodegeneration in Alzheimer's disease Open
Summary. Apolipoprotein E (APOE) is a glycoprotein primarily produced by astrocytes and microglia. It plays a crucial role in complexing with amyloid β (Aβ) to accelerate its clearance. APOE genotyping holds great importance in determining…
View article: ASSESSMENT OF THE INSTRUMENTAL ACTIVITIES OF DAILY LIVING IN MILD COGNITIVE IMPAIRMENT AND DEMENTIA DUE TO ALZHEIMER'S DISEASE: DIAGNOSTIC ACCURACY OF THE SERBIAN VERSION OF THE AMSTERDAM IADL QUESTIONNAIRE
ASSESSMENT OF THE INSTRUMENTAL ACTIVITIES OF DAILY LIVING IN MILD COGNITIVE IMPAIRMENT AND DEMENTIA DUE TO ALZHEIMER'S DISEASE: DIAGNOSTIC ACCURACY OF THE SERBIAN VERSION OF THE AMSTERDAM IADL QUESTIONNAIRE Open
To establish a diagnosis of dementia, it is necessary, in addition to cognitive impairment, to prove the existence of a disorder of instrumental activities of daily living (IADL). The Amsterdam IADL Questionnaire is a reliable instrument t…
View article: Association of the apolipoprotein E ε4 allele in a Serbian population with Alzheimer’s dementia
Association of the apolipoprotein E ε4 allele in a Serbian population with Alzheimer’s dementia Open
Although single nucleotide polymorphisms rs429358 and rs7412 in the apolipoprotein E gene (APOE) are widely investigated to analyze APOE alleles, there are no data on their association with Alzheimer?s disease (AD) dementia in a Serbian po…
View article: MicroRNA: Potential biomarkers in chronic kidney disease
MicroRNA: Potential biomarkers in chronic kidney disease Open
<jats:p>Introduction. Standard biomarkers for the diagnosis and follow-up of chronic kidney disease patients are appropriate neither in early diagnostics, adequate follow-up and progression assessment nor in complication development …
View article: Association of rs780094 and rs1260326 glucokinase regulatory protein gene polymorphisms with dyslipidemia in a group of Serbian acute ischemic stroke patients
Association of rs780094 and rs1260326 glucokinase regulatory protein gene polymorphisms with dyslipidemia in a group of Serbian acute ischemic stroke patients Open
Although genetic variations rs780094 and rs1260326 of the glucokinase regulatory protein gene (GCKR) could be associated with lipid profile imbalance, their influence on acute ischemic stroke (AIS) risk has not yet been established. The ai…
View article: Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue
Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue Open
Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patien…
View article: Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach
Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach Open
Background: Tacrolimus (Tac) is characterized by large between- and within-patient (IPV) variability in pharmacokinetics and exposure. Aim: This study aimed to assess and validate the effect of Tac IPV and trough concentration-to-dose rati…
View article: THE RELATIONSHIP BETWEEN SERUM CONCENTRATION OF TNF- AND INSULIN SENSITIVITY IN RATS WITH DIABETES MELLITUS TYPE 2
THE RELATIONSHIP BETWEEN SERUM CONCENTRATION OF TNF- AND INSULIN SENSITIVITY IN RATS WITH DIABETES MELLITUS TYPE 2 Open
Diabetes and obesity are very common associated metabolic disorders that are linked to chronic inflammation. The development of insulin resistance is driven by multiple factors including an increase in levels of pro-inflammatory cytokines …
View article: Bleeding Index and Monocyte Chemoattractant Protein 1 as Gingival Inflammation Parameters after Chemical-Mechanical Retraction Procedure
Bleeding Index and Monocyte Chemoattractant Protein 1 as Gingival Inflammation Parameters after Chemical-Mechanical Retraction Procedure Open
Objective: A widely used chemical-mechanical method of gingival retraction can cause gingival tissue damage. The aim of this study was to test the influence of the chemical-mechanical gingival retraction procedures on the gingival bleeding…
View article: How students understand spirituality and spiritual care: Descriptive study on a sample of bachelor nursing students from Slovenia
How students understand spirituality and spiritual care: Descriptive study on a sample of bachelor nursing students from Slovenia Open
Výzkum poukazuje na potencionální roli specifického kulturního prostředí, které hraje roli při porozumění spirituality a duchovní péče mezi ošetřujícím personálem a studenty. Duchovní péče se ve Slovinsku stále vyvíjí a zvyšuje se i úsilí …
View article: Data for: The Oxytocin Receptor (OXTR) Gene polymorphisms and recognition memory for emotional and neutral faces: A pilot study
Data for: The Oxytocin Receptor (OXTR) Gene polymorphisms and recognition memory for emotional and neutral faces: A pilot study Open
Research data, SPSS file
View article: INTERINDIVIDUAL AND INTRAINDIVIDUAL PHARMACOKINETIC VARIABILITY OF TACROLIMUS WITHIN THE FIRST YEAR AFTER RENAL TRANSPLANTATION: EFFECT OF CYP3A5 GENE POLYMORPHISM
INTERINDIVIDUAL AND INTRAINDIVIDUAL PHARMACOKINETIC VARIABILITY OF TACROLIMUS WITHIN THE FIRST YEAR AFTER RENAL TRANSPLANTATION: EFFECT OF CYP3A5 GENE POLYMORPHISM Open
The aim of this study was to evaluate potential influence of cytochrome P450 3A5 (CYP3A5) 6986A>G gene polymorphisms on interand intravariability (IPV) in tacrolimus (Tac) exposure within the first year after renal transplantation. Seconda…
View article: THE INFLUENCE OF CAT - 262 C/T POLYMORPHISM ON CATALASE ACTIVITY IN PATIENTS WITH ISCHEMIC STROKE
THE INFLUENCE OF CAT - 262 C/T POLYMORPHISM ON CATALASE ACTIVITY IN PATIENTS WITH ISCHEMIC STROKE Open
Although there is a disturbance of oxidative stress markers in acute ischemic stroke (AIS), genetic contribution of -262C/T polymorphism of catalase (CAT) gene on plasma CAT activity in this disease is not yet established. The aim of this …
View article: The influence of rs53576 and rs2254298 oxytocin receptor gene polymorphisms on plasma oxytocin levels and measures of empathy
The influence of rs53576 and rs2254298 oxytocin receptor gene polymorphisms on plasma oxytocin levels and measures of empathy Open
Oxytocin achieves its effects after binding the oxytocin receptor (OXTR). Oxytocin plays an important role in empathy. The aim of this study was to examine the influence of two single nucleotide polymorphisms (SNPs) of the OXTR gene (rs535…
View article: OXTR SNPs, oxytocin levels and empathy
OXTR SNPs, oxytocin levels and empathy Open
We examined the influence of two single nucleotide polymorphisms (SNPs) of the OXTR gene (rs53576 and rs2254298) on both empathy and plasma oxytocin levels in students. The column A shows a number of each subject. In the column B are showe…
View article: Sensitivity and specificity of D-dimer tests comparing to the ultrasound examination of deep vein thrombosis
Sensitivity and specificity of D-dimer tests comparing to the ultrasound examination of deep vein thrombosis Open
Introduction/Objective. Untreated deep vein thrombosis (DVT) is associated with a high risk of pulmonary embolism (PE), and false diagnosis of DVT results in unnecessary anticoagulant therapy, with a risk of bleeding. Accurate diagnosis of…
View article: EFFECTS OF METFORMIN ON PARAMETERS OF OXIDATIVE DAMAGE IN THE RETINA OF RATS WITH IMPAIRED GLUCOSE TOLERANCE
EFFECTS OF METFORMIN ON PARAMETERS OF OXIDATIVE DAMAGE IN THE RETINA OF RATS WITH IMPAIRED GLUCOSE TOLERANCE Open
Impaired glucose tolerance is a state characterized by hyperglycemia, but with the levels of blood glucose between normal and diabetic values.Diabetic retinopathy is a complication of diabetes the pathogenesis of which is associated with o…
View article: Polyamines, folic acid supplementation and cancerogenesis
Polyamines, folic acid supplementation and cancerogenesis Open
Clinical practice and experimental studies have shown the necessity of sufficient quantities of folic acid intake for normal embryogenesis and fetal development in the prevention of neural tube defects (NTDs) and neurological malformations…
View article: Catalase C-262T Gene Variant in Patients with Bronchial Asthma
Catalase C-262T Gene Variant in Patients with Bronchial Asthma Open
Summary Bronchial asthma (BA) is a chronic inflammatory disease of the airways in the pathogenesis of which oxidative stress has a very important role. Single nucleotide polymorphisms (SNPs) in catalase gene may result in decreased antioxi…
View article: PARAMETERS OF OXIDATIVE STRESS IN COLON CANCER TISSUE
PARAMETERS OF OXIDATIVE STRESS IN COLON CANCER TISSUE Open
Colorectal cancer is one of the most frequent neoplastic diseases in the human population, and one of the most frequent causes of death. Reactive oxygen species (ROS) are involved in the process of cancer initiation and progression. It is …
View article: Evaluation of ghrelin and leptin levels in obese, lean and undernourished children
Evaluation of ghrelin and leptin levels in obese, lean and undernourished children Open
Background/Aims: Energy homeostasis is a balance between energy intake and energy expenditure. Leptin and ghrelin are two orexitropic hormones with opposite effect on energy homeostasis. We investigated fasting ghrelin and leptin levels in…