Explanipedia

Direct Endovascular Versus Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery: A MR CLEAN Registry Study Open

Mohamed Fahmy Doheim, Robrecht R.M.M. Knapen, Julie Staals, Wouter J. Schonewille, Diederik W.J. Dippel , et al. · 2025

BACKGROUND: The optimal strategy for managing M2 segment occlusions of the middle cerebral artery, whether with direct endovascular treatment (EVT) or bridging therapy with intravenous thrombolysis (IVT) before EVT, remains unclear. This s…

National trends in patient characteristics, interventional techniques and outcomes of endovascular treatment for acute ischaemic stroke: Final results of the MR CLEAN Registry (2014–2018) Open

Wouter H. Hinsenveld, Josje Brouwer, Sanne J. den Hartog, Agnetha A.E. Bruggeman, Manon Kappelhof , et al. · 2025

Introduction: Endovascular thrombectomy (EVT) procedures and workflow have evolved over the years. We examined trends in patient characteristics, EVT techniques and outcomes over 5 years in the Netherlands. Patients and methods: Data from …

Quality Improvement Intervention for Reducing Acute Treatment Times in Ischemic Stroke Open

Daniël Hansen, Sanne J. den Hartog, Nikki van Leeuwen, Jelis Boiten, Wouter Dinkelaar , et al. · 2024

Importance Efficient care processes are crucial to minimize treatment delays and improve outcome after endovascular thrombectomy (EVT) in patients with ischemic stroke. A potential means to improve care processes is performance feedback. O…

Deep learning-based white matter lesion volume on CT is associated with outcome after acute ischemic stroke Open

Henk van Voorst, Johanna Pitkänen, Laura van Poppel, Lucas de Vries, Mahsa Mojtahedi , et al. · 2024

Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study Open

Robrecht R.M.M. Knapen, F.A.V. Pirson, Lucianne C.M. Langezaal, Josje Brouwer, Charles B.L.M. Majoie , et al. · 2024

BACKGROUND: The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. These studies mainly concerned anterior circulation occlusions. We aimed to i…

Outcome of patients with multivessel occlusion stroke after endovascular treatment Open

Natalie E. LeCouffe, Kilian M. Treurniet, Manon Kappelhof, Ivo G.H. Jansen, Merel Boers , et al. · 2023

Introduction: Little is known about the implications of multivessel occlusions (MVO) in large vessel occlusion stroke patients who undergo endovascular treatment (EVT). Patients and methods: We report data from the MR CLEAN Registry: a pro…

Clinical consequence of vessel perforations during endovascular treatment of acute ischemic stroke Open

Matthijs van der Sluijs, Ruisheng Su, Sandra Cornelissen, Adriaan C.G.M. van Es, Geert J. Lycklama à Nijeholt , et al. · 2023

Early Intubation in Endovascular Therapy for Basilar Artery Occlusion: A Post Hoc Analysis of the BASICS Trial Open

Kristian Barlinn, Lucianne C.M. Langezaal, Diederik W.J. Dippel, Wim H. van Zwam, Martin Roessler , et al. · 2023

BACKGROUND: The optimal anesthetic management for endovascular therapy (EVT) in patients with posterior circulation stroke remains unclear. Our objective was to investigate the impact of early intubation in patients enrolled in the BASICS …

Cost-effectiveness of CT perfusion for the detection of large vessel occlusion acute ischemic stroke followed by endovascular treatment: a model-based health economic evaluation study Open

Henk van Voorst, Jan W. Hoving, Miou S. Koopman, Jasper D. Daems, Daan Peerlings , et al. · 2023

Development and Validation of a Postprocedural Model to Predict Outcome After Endovascular Treatment for Ischemic Stroke Open

Vicky Chalos, Esmée Venema, Maxim J.H.L. Mulder, Bob Roozenbeek, Ewout W. Steyerberg , et al. · 2023

Importance Outcome prediction after endovascular treatment (EVT) for ischemic stroke is important to patients, family members, and physicians. Objective To develop and validate a model based on preprocedural and postprocedural characterist…

Aspiration Versus Stent Retriever Thrombectomy in Basilar‐Artery Occlusion; Results From the BASICS Trial Open

Robrecht R.M.M. Knapen, Marie Louise E. Bernsen, Lucianne C.M. Langezaal, Susanne G H Olthuis, Patrik Michel , et al. · 2023

Background Both aspiration and stent retriever thrombectomy are safe and effective in patients with acute ischemic stroke due to large vessel occlusion in the anterior circulation. Little is known on the outcomes of these techniques in pat…

Safety and technical efficacy of early minimally invasive endoscopy-guided surgery for intracerebral haemorrhage: the Dutch Intracerebral haemorrhage Surgery Trial pilot study Open

Lotte Sondag, Floris H.B.M. Schreuder, Sjoert Pegge, Jonathan M. Coutinho, Diederik W.J. Dippel , et al. · 2023

Validity of Early Outcomes as Indicators for Comparing Hospitals on Quality of Stroke Care Open

Marzyeh Amini, Frank Eijkenaar, Hester F. Lingsma, Sanne J. den Hartog, Susanne G H Olthuis , et al. · 2023

Background Insight into outcome variation between hospitals could help to improve quality of care. We aimed to assess the validity of early outcomes as quality indicators for acute ischemic stroke care for patients treated with endovascula…

Prognostic Value of Thrombus Volume and Interaction With First-Line Endovascular Treatment Device Choice Open

Henk van Voorst, Agnetha A.E. Bruggeman, Jurr O. Andriessen, Jan W. Hoving, Praneeta R. Konduri , et al. · 2023

Background: A larger thrombus in patients with acute ischemic stroke might result in more complex endovascular treatment procedures, resulting in poorer patient outcomes. Current evidence on thrombus volume and length related to procedural…

Association between thrombus composition and stroke etiology in the MR CLEAN Registry biobank Open

Hajo Hund, Nikki Boodt, Daniël Hansen, Willem A. Haffmans, Geert J. Lycklama à Nijeholt , et al. · 2023

Symptomatic Intracranial Hemorrhage After Endovascular Stroke Treatment: External Validation of Prediction Models Open

Nadinda A.M. van der Ende, Femke C.C. Kremers, Wouter van der Steen, Esmée Venema, Manon Kappelhof , et al. · 2023

Background: Symptomatic intracranial hemorrhage (sICH) is a severe complication of reperfusion therapy for ischemic stroke. Multiple models have been developed to predict sICH or intracranial hemorrhage (ICH) after reperfusion therapy. We …

Circle of Willis variation and outcome after intra-arterial treatment Open

Anouk D. Rozeman, Hajo Hund, Jelis Boiten, Jan Albert Vos, Wouter J. Schonewille , et al. · 2022

Background Intra-arterial treatment (IAT) improves outcomes in acute ischaemic stroke. Presence of collaterals increases likelihood of good outcome. We investigated whether variations in the circle of Willis (CoW) and contributing carotid …

Effect of Intravenous Alteplase Treatment on First-Line Stent Retriever Versus Aspiration Alone During Endovascular Treatment Open

Leon A. Rinkel, Kilian M. Treurniet, Daan Nieboer, Manon Kappelhof, Natalie E. LeCouffe , et al. · 2022

Background: We aimed to assess whether the effect of intravenous alteplase treatment (IVT) before endovascular treatment (EVT) on outcome is modified by first-line technique during EVT in IVT eligible patients. Methods: This was a post hoc…

Determinants of Symptomatic Intracranial Hemorrhage After Endovascular Stroke Treatment: A Retrospective Cohort Study Open

Wouter van der Steen, Nadinda A.M. van der Ende, Katinka R. van Kranendonk, Vicky Chalos, Robert J. van Oostenbrugge , et al. · 2022

Background: Symptomatic intracranial hemorrhage (sICH) is a serious complication after endovascular treatment for ischemic stroke. We aimed to identify determinants of its occurrence and location. Methods: We retrospectively analyzed data …

Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry Open

F.A.V. Pirson, Nikki Boodt, Josje Brouwer, Agnetha A.E. Bruggeman, Wouter H. Hinsenveld , et al. · 2022

Background: In patients with large vessel occlusion stroke of the anterior circulation, underlying cause is a determinant of outcome. Whether this is the case for posterior circulation large vessel occlusion stroke has yet to be determined…

Estimation of treatment effects in observational stroke care data: comparison of statistical approaches Open

Marzyeh Amini, Nikki van Leeuwen, Frank Eijkenaar, Rob van de Graaf, Noor Samuels , et al. · 2022

Introduction Various statistical approaches can be used to deal with unmeasured confounding when estimating treatment effects in observational studies, each with its own pros and cons. This study aimed to compare treatment effects as estim…

Endovascular Treatment for Posterior Circulation Stroke in Routine Clinical Practice:Results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry Open

F.A.V. Pirson, Nikki Boodt, Josje Brouwer, Agnetha A.E. Bruggeman, Sanne J. den Hartog , et al. · 2022

The benefit of endovascular treatment (EVT) for posterior circulation stroke (PCS) remains uncertain, and little is known on treatment outcomes in clinical practice. This study evaluates outcomes of a large PCS cohort treated with EVT in c…

Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial Open

Wouter van der Steen, Rob A. van de Graaf, Vicky Chalos, Hester F. Lingsma, Pieter Jan van Doormaal , et al. · 2022

Improvements in Endovascular Treatment for Acute Ischemic Stroke: A Longitudinal Study in the MR CLEAN Registry Open

Kars C.J. Compagne, Manon Kappelhof, Wouter H. Hinsenveld, Josje Brouwer, Robert‐Jan B. Goldhoorn , et al. · 2022

Background: We evaluated data from all patients in the Netherlands who underwent endovascular treatment for acute ischemic stroke in the past 3.5 years, to identify nationwide trends in time to treatment and procedural success, and assess …

Clinical Outcome After Endovascular Treatment in Patients With Active Cancer and Ischemic Stroke Open

Merelijne A. Verschoof, Adrien E.D. Groot, Sebastiaan F.T.M. de Bruijn, Bob Roozenbeek, H. Bart van der Worp , et al. · 2022

This study provides Class I evidence that patients with active cancer undergoing EVT for AIS have worse functional outcomes at 90 days compared to those without active cancer.

Added Value of a Blinded Outcome Adjudication Committee in an Open-Label Randomized Stroke Trial Open

Nadinda A.M. van der Ende, Bob Roozenbeek, Olvert A. Berkhemer, Peter J. Koudstaal, Jelis Boiten , et al. · 2022

Blinded outcome assessment in trials with prospective randomized open blinded end point design is challenging. Unblinding can result in misclassified outcomes and biased treatment effect estimates. An outcome adjudication committee assures…

Hospital Variation in Time to Endovascular Treatment for Ischemic Stroke: What Is the Optimal Target for Improvement? Open

Sanne J. den Hartog, Hester F. Lingsma, Pieter‐Jan van Doormaal, Jeannette Hofmeijer, Lonneke S.F. Yo , et al. · 2021

Background Time to reperfusion in patients with ischemic stroke is strongly associated with functional outcome and may differ between hospitals and between patients within hospitals. Improvement in time to reperfusion can be guided by betw…

Performance feedback on the quality of care in hospitals performing thrombectomy for ischemic stroke (PERFEQTOS): protocol of a stepped wedge cluster randomized trial Open

Marzyeh Amini, Sanne J. den Hartog, Nikki van Leeuwen, Frank Eijkenaar, Laurien S. Kuhrij , et al. · 2021

A randomized trial of intravenous alteplase before endovascular treatment for stroke Open

Natalie E. LeCouffe, Manon Kappelhof, Kilian M. Treurniet, Leon A. Rinkel, Agnetha A.E. Bruggeman , et al. · 2021

The value of administering intravenous alteplase before endovascular treatment (EVT) for acute ischemic stroke has not been studied extensively, particularly in non-Asian populations.

Blood Pressure in the First 6 Hours Following Endovascular Treatment for Ischemic Stroke Is Associated With Outcome Open

Noor Samuels, Rob A. van de Graaf, Carlijn A.L. van den Berg, Simone M. Uniken Venema, Kujtesa Bala , et al. · 2021

Background and Purpose: Optimal blood pressure (BP) management in the acute phase of ischemic stroke remains an unresolved issue. It is uncertain whether guidelines for BP management during and after intravenous alteplase can be extrapolat…

Jelis Boiten YOU? Author Swipe