Jelle Miedema
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View article: Screening for cardiac sarcoidosis: diagnostic approach and long-term follow-up in a tertiary centre
Screening for cardiac sarcoidosis: diagnostic approach and long-term follow-up in a tertiary centre Open
Background Cardiac sarcoidosis (CS) is associated with poor prognosis, making early diagnosis and treatment important. This study evaluated the results of a diagnostic approach in patients with known sarcoidosis and suspected cardiac invol…
View article: Increased proportions of circulating PD-1+ CD4+ memory T cells and PD-1+ regulatory T cells associate with good response to prednisone in pulmonary sarcoidosis
Increased proportions of circulating PD-1+ CD4+ memory T cells and PD-1+ regulatory T cells associate with good response to prednisone in pulmonary sarcoidosis Open
Background The treatment response to corticosteroids in patients with sarcoidosis is highly variable. CD4 + T cells are central in sarcoid pathogenesis and their phenotype in peripheral blood (PB) associates with disease course. We hypothe…
View article: Circulating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome
Circulating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome Open
Circulating T cell subpopulations of sarcoidosis patients display phenotypic abnormalities that correlate with disease outcome, supporting a critical role of aberrant T cell activation in sarcoidosis pathogenesis.
View article: Antibodies against angiotensin II receptor type 1 and endothelin A receptor are increased in COVID-19 patients
Antibodies against angiotensin II receptor type 1 and endothelin A receptor are increased in COVID-19 patients Open
Background Increased titers of autoantibodies targeting the G-protein-coupled receptors angiotensin II type 1 receptor (AT1R) and endotelin-1 type A receptor (ETAR) are associated with severe coronavirus disease 2019 (COVID-19) infection. …
View article: Unilateral Diaphragmatic Weakness After Stereotactic Radiotherapy of The Lung: A Case Report
Unilateral Diaphragmatic Weakness After Stereotactic Radiotherapy of The Lung: A Case Report Open
Stereotactic body radiation therapy (SBRT) is the treatment of choice for patients with stage 1 non-small cell lung cancer (NSCLC) who are medically unfit or those refusing surgery. SBRT is a modality which is well tolerated with respect t…
View article: Comparison of the treatment guidelines for sarcoidosis: common sense in the search for evidence
Comparison of the treatment guidelines for sarcoidosis: common sense in the search for evidence Open
A perspective on the recently published ERS clinical practice guideline on treatment of sarcoidosis: although knowledge of the pathogenesis of sarcoidosis has improved, this has not yet translated into better evidence-based therapieshttps:…
View article: COVID outcome prediction in the emergency department (COPE): using retrospective Dutch hospital data to develop simple and valid models for predicting mortality and need for intensive care unit admission in patients who present at the emergency department with suspected COVID-19
COVID outcome prediction in the emergency department (COPE): using retrospective Dutch hospital data to develop simple and valid models for predicting mortality and need for intensive care unit admission in patients who present at the emergency department with suspected COVID-19 Open
Objectives Develop simple and valid models for predicting mortality and need for intensive care unit (ICU) admission in patients who present at the emergency department (ED) with suspected COVID-19. Design Retrospective. Setting Secondary …
View article: Drug-induced sarcoidosis-like reactions
Drug-induced sarcoidosis-like reactions Open
Purpose of review Sarcoidosis is a complex granulomatous disease of unknown cause. Several drug categories are able to induce a systemic granulomatous indistinguishable from sarcoidosis, known as drug-induced sarcoidosis-like reaction (DIS…
View article: Antibodies Against Angiotensin II Receptor Type 1 and Endothelin A Receptor Are Associated With an Unfavorable COVID19 Disease Course
Antibodies Against Angiotensin II Receptor Type 1 and Endothelin A Receptor Are Associated With an Unfavorable COVID19 Disease Course Open
Background Lung histopathology demonstrates vasculopathy in a subset of deceased COVID19 patients, which resembles histopathology observed in antibody-mediated lung transplant rejection. Autoantibodies against angiotensin II type 1 recepto…
View article: COVID Outcome Prediction in the Emergency Department (COPE): Development and validation of a model for predicting death and need for intensive care in COVID-19 patients
COVID Outcome Prediction in the Emergency Department (COPE): Development and validation of a model for predicting death and need for intensive care in COVID-19 patients Open
Background and aim COVID-19 is putting extraordinary pressure on emergency departments (EDs). To support decision making in the ED, we aimed to develop a simple and valid model for predicting mortality and need for intensive care unit (ICU…
View article: The Value of the Surprise Question to Predict One-Year Mortality in Idiopathic Pulmonary Fibrosis: A Prospective Cohort Study
The Value of the Surprise Question to Predict One-Year Mortality in Idiopathic Pulmonary Fibrosis: A Prospective Cohort Study Open
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive fatal disease with a heterogeneous disease course. Timely initiation of palliative care is often lacking. The surprise question “Would you be surprised if this patient died w…
View article: Effects of Potent Neutralizing Antibodies from Convalescent Plasma in Patients Hospitalized for Severe SARS-CoV-2 Infection.
Effects of Potent Neutralizing Antibodies from Convalescent Plasma in Patients Hospitalized for Severe SARS-CoV-2 Infection. Open
Convalescent plasma could be an inexpensive and widely available treatment for COVID-19 patients but reports on effectiveness are inconclusive. We collected convalescent plasma from donors with high titers of neutralizing anti-SARS-CoV-2 a…
View article: Economic Burden and Management of Systemic Sclerosis-Associated Interstitial Lung Disease in 8 European Countries: The BUILDup Delphi Consensus Study
Economic Burden and Management of Systemic Sclerosis-Associated Interstitial Lung Disease in 8 European Countries: The BUILDup Delphi Consensus Study Open
SSc-ILD entails not only a clinical but also a social and economic burden, and is higher for E-SSc-ILD.
View article: Case report: a fatal combination of hemophagocytic lymphohistiocytosis with extensive pulmonary microvascular damage in COVID-19 pneumonia
Case report: a fatal combination of hemophagocytic lymphohistiocytosis with extensive pulmonary microvascular damage in COVID-19 pneumonia Open
The clinical features of COVID-19 have a considerable range from a mild illness to severe disease. Underlying pathophysiological mechanisms of the rapidly progressive, and often fatal, pulmonary disease frequently observed in COVID-19 need…
View article: Convalescent Plasma for COVID-19. A randomized clinical trial
Convalescent Plasma for COVID-19. A randomized clinical trial Open
Structured abstract for full paper Background After recovery from COVID-19, most patients have anti-SARS-CoV-2 neutralizing antibodies. Their convalescent plasma could be an inexpensive and widely available treatment for COVID-19. Methods …