Jelle Vlaeminck
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View article: Genetic variants associated with ventricular arrhythmias during ajmaline test in Brugada syndrome
Genetic variants associated with ventricular arrhythmias during ajmaline test in Brugada syndrome Open
Graphical AbstractPathogenic/Likely Pathogenic variants identified in SCN5A and associated with ajmaline-induced ventricular fibrillation following ACMG guidelines
View article: Case Report: A first case of desmin-related myofibrillar myopathy due to inheritance from a confirmed mosaic asymptomatic carrier
Case Report: A first case of desmin-related myofibrillar myopathy due to inheritance from a confirmed mosaic asymptomatic carrier Open
Desmin-related myofibrillar myopathy is a hereditary disorder caused by pathogenic variants in the DES gene (MIM*125660), altering desmin, a muscle-specific intermediate filament which is crucial for sarcomere integrity. This condition pre…
View article: Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant
Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant Open
Variations in the activity of the enzyme dihydropyrimidine dehydrogenase (DPD) are associated with toxicity to fluoropyrimidine-containing chemotherapy. Testing of DPD deficiency either by targeted genotyping of the corresponding DPYD gene…
View article: Association of <i>Staphylococcus aureus</i> Bacterial Load and Colonization Sites With the Risk of Postoperative <i>S. aureus</i> Infection
Association of <i>Staphylococcus aureus</i> Bacterial Load and Colonization Sites With the Risk of Postoperative <i>S. aureus</i> Infection Open
Background The independent effects of extranasal-only carriage, carriage at multiple bodily sites, or the bacterial load of colonizing Staphylococcus aureus (SA) on the risk of developing SA surgical site infections and postoperative blood…
View article: Frequent host-switch and gene exchange shape the evolution of Staphylococcus aureus ST398
Frequent host-switch and gene exchange shape the evolution of Staphylococcus aureus ST398 Open
Staphylococcus aureus ST398 is a typical ‘One Health’ pathobiont exemplifying multiple-host tropisms. Here we traced the evolutionary trajectory of the global accessory genome (an assembly of accessory genes) of S. aureus ST398 over 20 yea…
View article: Correction: Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia
Correction: Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia Open
View article: Postoperative <i>Staphylococcus aureus</i> Infections in Patients With and Without Preoperative Colonization
Postoperative <i>Staphylococcus aureus</i> Infections in Patients With and Without Preoperative Colonization Open
Importance Staphylococcus aureus surgical site infections (SSIs) and bloodstream infections (BSIs) are important complications of surgical procedures for which prevention remains suboptimal. Contemporary data on the incidence of and etiolo…
View article: Variant-Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes in Human Cancer
Variant-Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes in Human Cancer Open
In this cross-sectional study, we report the findings of our investigation into the mutual exclusivity (ME) and co-occurrence (CO) patterns of BRAF, KRAS, and EGFR mutations in human cancer. Our analysis acknowledges previously overlooked …
View article: Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia
Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia Open
View article: Genomic analysis of methicillin-resistant Staphylococcus aureus clonal complex 239 isolated from Danish patients with and without an international travel history
Genomic analysis of methicillin-resistant Staphylococcus aureus clonal complex 239 isolated from Danish patients with and without an international travel history Open
Introduction International travel has been a major determinant for the introduction of pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) into naïve geographic areas. MRSA clonal complex 239 (CC239) is a highly virulent c…
View article: The dynamic transcriptome during maturation of biofilms formed by methicillin-resistant Staphylococcus aureus
The dynamic transcriptome during maturation of biofilms formed by methicillin-resistant Staphylococcus aureus Open
Background Methicillin-resistant Staphylococcus aureus (MRSA), a leading cause of chronic infections, forms prolific biofilms which afford an escape route from antibiotic treatment and host immunity. However, MRSA clones are genetically di…
View article: Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia
Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia Open
Pneumonia is an acute pulmonary infection associated with high mortality and an immense financial burden on healthcare systems. Staphylococcus aureus is an opportunistic pathogen capable of inducing S. aureus pneumonia (SAP), with some lin…