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View article: Myeloid cell differentiation within extracorporeal membrane oxygenators in patients with ARDS
Myeloid cell differentiation within extracorporeal membrane oxygenators in patients with ARDS Open
Extracorporeal membrane oxygenation is a last-resort rescue therapy for patients with acute respiratory distress syndrome (ARDS). The membrane oxygenator (MO) is prone to coagulation and dysfunction. Studies have shown that circulating cel…
View article: Receptor agonist of NFκB signaling ligand directs lung epithelial cell expansion through RANK signaling
Receptor agonist of NFκB signaling ligand directs lung epithelial cell expansion through RANK signaling Open
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally, with progressive emphysema driven by repeated epithelial damage and impaired repair. Recently, we found that secretion of the osteokine “receptor ag…
View article: Deciphering lung epithelial cell differentiation and repair in chronic lung diseases
Deciphering lung epithelial cell differentiation and repair in chronic lung diseases Open
Chronic lung diseases asthma and COPD contribute substantially to global disease burden. The lung epithelium plays a crucial role in the development and progression of asthma and COPD, as its phenotype has been shown to be altered in both …
View article: TRAPping the effects of tobacco smoking: the regulation and function of <i>Acp5</i> expression in lung macrophages
TRAPping the effects of tobacco smoking: the regulation and function of <i>Acp5</i> expression in lung macrophages Open
This study has uncovered that the enzyme tartrate-resistant acid phosphatase (TRAP) is crucial for alveolar macrophage proliferation through a β-catenin-dependent pathway. Importantly, TRAP influences this important ability of alveolar mac…
View article: Gene signatures in U-BIOPRED severe asthma for molecular phenotyping and precision medicine: time for clinical use
Gene signatures in U-BIOPRED severe asthma for molecular phenotyping and precision medicine: time for clinical use Open
Phenotyping on the basis of clinical treatable traits is not sufficient for understanding of mechanisms driving the disease in severe asthma. It is time to consider whether certain patients with severe asthma, such as those non-responsive …
View article: Role of RANKL in Alveolar Epithelial Cell Regeneration: Potential Novel Contributor to Lung Tissue Repair
Role of RANKL in Alveolar Epithelial Cell Regeneration: Potential Novel Contributor to Lung Tissue Repair Open
Receptor activator for NF-κβ (RANK) ligand (RANKL) is found in lung tissue and elevated in lung diseases like chronic obstructive pulmonary disease (COPD), cystic fibrosis and silica-induced pulmonary fibrosis. RANKL is a well-known stimul…