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View article: Lower Respiratory Tract Bacterial Profiles Are Associated With Respiratory Severity and Bronchopulmonary Dysplasia in Neonates
Lower Respiratory Tract Bacterial Profiles Are Associated With Respiratory Severity and Bronchopulmonary Dysplasia in Neonates Open
Introduction Bronchopulmonary dysplasia (BPD) is a major complication of prematurity, marked by heterogeneous pulmonary phenotypes and variable clinical outcomes. The airway microbiome may influence disease severity and progression, yet qu…
View article: The impact of prematurity on pediatric asthma morbidity and indices with environmental pollution and genetic susceptibility
The impact of prematurity on pediatric asthma morbidity and indices with environmental pollution and genetic susceptibility Open
Interactions between prematurity, PM2.5 exposure, and genetic susceptibility exacerbate asthma morbidity, underscoring the urgent need for targeted interventions in high-risk populations with overlapping vulnerabilities.
View article: PM2.5 exposure and household income are associated with lung function abnormalities in children with sickle cell disease
PM2.5 exposure and household income are associated with lung function abnormalities in children with sickle cell disease Open
Rationale Cardiopulmonary dysfunction is a major contributor to mortality among persons with sickle cell disease (pwSCD). Despite this, little is known regarding environmental drivers of lung function decline. Objective We hypothesized tha…
View article: Outpatient inhaled corticosteroid use in bronchopulmonary dysplasia
Outpatient inhaled corticosteroid use in bronchopulmonary dysplasia Open
Rationale In the outpatient setting, inhaled corticosteroids (ICS) are frequently given to children with bronchopulmonary dysplasia (BPD) for treatment of respiratory and asthma‐associated symptoms. In this study we sought to determine if …
View article: Indoor air pollution increases during wildfires for children with bronchopulmonary dysplasia
Indoor air pollution increases during wildfires for children with bronchopulmonary dysplasia Open
Wildfires are becoming a more frequent and significant problem due to climate change. Wildfire smoke, a combination of air pollutants, is hazardous to respiratory health, leading to public health advisories to remain indoors. However, smok…
View article: GWAS reveals Genetic Susceptibility to Air Pollution-Related Asthma Exacerbations in Children of African Ancestry
GWAS reveals Genetic Susceptibility to Air Pollution-Related Asthma Exacerbations in Children of African Ancestry Open
Background The relationship between ambient air pollution (AAP) exposure and asthma exacerbations is well-established. However, mitigation efforts have yielded mixed results, potentially due to genetic variability in the response to AAP. W…
View article: Outpatient Inhaled Corticosteroid Use in Bronchopulmonary Dysplasia
Outpatient Inhaled Corticosteroid Use in Bronchopulmonary Dysplasia Open
Rationale: In the outpatient setting, inhaled corticosteroids (ICS) are frequently given to children with bronchopulmonary dysplasia (BPD) for treatment of respiratory and asthma associated symptoms. In this study we sought to determine if…
View article: Phenotype wide association study links bronchopulmonary dysplasia with eosinophilia in children
Phenotype wide association study links bronchopulmonary dysplasia with eosinophilia in children Open
Bronchopulmonary dysplasia (BPD) is a frequent complication of preterm birth. Despite this, genetic drivers of BPD are poorly understood. The objective of this study is to better understand the impact of if single nucleotide polymorphisms …
View article: Ambient Air Pollution and Outpatient Morbidities in Bronchopulmonary Dysplasia
Ambient Air Pollution and Outpatient Morbidities in Bronchopulmonary Dysplasia Open
Rationale: Bronchopulmonary dysplasia (BPD) is the most common long-term complication of prematurity. Although socioeconomic status is associated with BPD morbidities, the drivers of this association are poorly understood. In the United St…
View article: The role of gene–ambient air pollution interactions in paediatric asthma
The role of gene–ambient air pollution interactions in paediatric asthma Open
Globally, asthma prevention and treatment remain a challenge. Ambient air pollution (AAP) is an environmental risk factor of special interest in asthma research. AAP is poorly defined and has been subdivided either by the origin of the air…
View article: Year in review 2021: Neuromuscular diseases
Year in review 2021: Neuromuscular diseases Open
In this years' review of neuromuscular respiratory medicine, there were a series of articles on home mechanical ventilation, real‐world studies assessing the impact of nusinersen, and studies describing upper airway dysfunction. Beyond thi…
View article: Diagnostic and management considerations in pseudohypoaldosteronism type 1b
Diagnostic and management considerations in pseudohypoaldosteronism type 1b Open
Pseudohypoaldosteronism type 1B is a rare autosomal recessive disorder caused by dysfunction of amiloride-sensitive epithelial sodium channels (ENaCs). We present the case of a neonate with cardiogenic shock after cardiac arrest due to pro…
View article: HIF-1α Pulmonary Phenotype Wide Association Study Unveils a Link to Inflammatory Airway Conditions
HIF-1α Pulmonary Phenotype Wide Association Study Unveils a Link to Inflammatory Airway Conditions Open
Despite experimental data linking HIF-1α dysfunction to inflammatory airway conditions, the effect of single nucleotide polymorphisms within the HIF1A gene on these conditions remains poorly understood. In the current study, we complete a …
View article: A Pediatric Case of Sirolimus-Associated Pneumonitis After Kidney Transplantation
A Pediatric Case of Sirolimus-Associated Pneumonitis After Kidney Transplantation Open
Sirolimus is an immunosuppressive medication often used in solid organ transplantation. It has been associated with severe side effects, including pulmonary toxicity. In adult patients, a single center study found that 14% of those treated…
View article: Clinical Characteristics of Infective Endocarditis in Children
Clinical Characteristics of Infective Endocarditis in Children Open
Background: Infective endocarditis (IE) remains a diagnostic and therapeutic challenge associated with high morbidity and mortality. We evaluated the microbial profile and clinical manifestation of IE in children. Methods: A retrospective …