Jelte M. M. Krol
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View article: The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vaccination strategy
The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vaccination strategy Open
Genetically attenuated parasites (GAPs) that arrest during liver stage development have shown significant potential as malaria vaccines. Compared to Plasmodium falciparum GAPs that arrest after 24–48 h (early-arresters), parasites arrestin…
View article: Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humans
Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humans Open
Malaria caused by Plasmodium falciparum remains one of the major infectious diseases with a high burden in Sub-Saharan Africa. In spite of the advancements made in vaccine development and implementation in endemic countries, sterile and du…
View article: Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humans
Correlative humoral and cellular immunity to genetically attenuated malaria parasites in humans Open
Malaria caused by Plasmodium falciparum remains one of the major infectious diseases with a high burden in Sub-Saharan Africa. In spite of the advancements made in vaccine development and implementation in endemic countries, sterile and du…
View article: Flp/ <i>FRT</i> -mediated disruption of <i>ptex150</i> and <i>exp2</i> in <i>Plasmodium falciparum</i> sporozoites inhibits liver-stage development
Flp/ <i>FRT</i> -mediated disruption of <i>ptex150</i> and <i>exp2</i> in <i>Plasmodium falciparum</i> sporozoites inhibits liver-stage development Open
Plasmodium falciparum causes severe malaria and assembles a protein translocon (PTEX) complex at the parasitophorous vacuole membrane (PVM) of infected erythrocytes, through which several hundred proteins are exported to facilitate growth.…
View article: Plasmodium falciparum exoerythrocytic forms require the PTEX translocon for development in human hepatocytes
Plasmodium falciparum exoerythrocytic forms require the PTEX translocon for development in human hepatocytes Open
Plasmodium falciparum assembles a protein translocon (PTEX) at the parasitophorous vacuole membrane (PVM) of infected erythrocytes, through which several hundred proteins are exported. The preceding Plasmodium liver stage develops in hepat…