Mark A. Jenkins
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View article: Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes
Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes Open
Background Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-charact…
View article: Cancer risks for MSH6 pathogenic variant carriers
Cancer risks for MSH6 pathogenic variant carriers Open
These refined, age- and sex-specific risk estimates for MSH6 PV carriers inform tailored surveillance strategies, supporting delayed CRC screening and individualised counselling on risk-reducing surgery for women.
View article: Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis
Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis Open
Australian Government.
View article: A prediction model for metachronous colorectal cancer: development and validation
A prediction model for metachronous colorectal cancer: development and validation Open
Background Being able to estimate the risk of metachronous disease in a patient with colorectal cancer (CRC) could enable risk-appropriate surveillance. The aim of this study was to develop a risk-prediction model to estimate individual 10…
View article: The effect and psychological mediators of a redesigned invitation letter to increase bowel cancer screening intention and likelihood: A randomised controlled experiment
The effect and psychological mediators of a redesigned invitation letter to increase bowel cancer screening intention and likelihood: A randomised controlled experiment Open
Invitation letters that highlight screening benefits and provide simple, practical guidance to support planning and self-efficacy may increase recipients' screening likelihood. Messaging reducing difficulty and avoidance barriers may be mo…
View article: Consumer perspectives on videos for promoting participation in population bowel cancer screening
Consumer perspectives on videos for promoting participation in population bowel cancer screening Open
Understanding consumer preferences for the use of promotional screening videos can inform the optimisation of videos to facilitate greater participation in population bowel screening programs.
View article: Performance of thermoablation among women treated for high‐risk human papillomavirus in a screen‐and‐treat program in South Africa
Performance of thermoablation among women treated for high‐risk human papillomavirus in a screen‐and‐treat program in South Africa Open
Thermal ablation is a simple treatment option for HPV‐associated, pre‐cancerous disease, has a low risk of complications and can be undertaken by non‐specialists. For these reasons, it is one of the recommended treatment modalities for cer…
View article: Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis
Age-specific trends in colorectal, appendiceal, and anal tumour incidence by histological subtype in Australia from 1990 to 2020: a population-based time-series analysis Open
Background Early-onset bowel cancer incidence (age <50 years) has increased worldwide and is highest in Australia, but how this varies across histology and anatomical site remains unclear. We aimed to investigate appendiceal, proximal colo…
View article: Metachronous colorectal cancer risks after extended or segmental resection in <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database
Metachronous colorectal cancer risks after extended or segmental resection in <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database Open
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch …
View article: Risks of colorectal and extracolonic cancers following colorectal cancer: a systematic review and meta-analysis
Risks of colorectal and extracolonic cancers following colorectal cancer: a systematic review and meta-analysis Open
Background Colorectal cancer survivors face increased risks of developing new primary cancers in colorectum and other anatomical sites. This systematic review aimed to estimate primary colorectal and extracolonic cancers risks following co…
View article: Optimising invitation and advance notification letters to increase bowel cancer screening participation: A qualitative analysis
Optimising invitation and advance notification letters to increase bowel cancer screening participation: A qualitative analysis Open
The simplification of letter design, and integration of tailored messaging strategies, simple kit instructions, reminders, and deadlines could boost engagement and help bridge the intention-behaviour gap, driving increased screening partic…
View article: Adenomas from individuals with pathogenic biallelic variants in the MUTYH and NTHL1 genes demonstrate base excision repair tumour mutational signature profiles similar to colorectal cancers, expanding potential diagnostic and variant classification applications
Adenomas from individuals with pathogenic biallelic variants in the MUTYH and NTHL1 genes demonstrate base excision repair tumour mutational signature profiles similar to colorectal cancers, expanding potential diagnostic and variant classification applications Open
SBS18+SBS36 and SBS30 were enriched in adenomas at comparable proportions to those observed in CRCs from biallelic MUTYH and biallelic NTHL1 cases, respectively. Therefore, testing adenomas may improve the identification of biallelic cases…
View article: Using an SMS to improve bowel cancer screening: the acceptability and feasibility of a multifaceted intervention
Using an SMS to improve bowel cancer screening: the acceptability and feasibility of a multifaceted intervention Open
Background The Australian National Bowel Cancer Screening Program sends an immunochemical faecal occult blood test to Australians aged 50–74 years to screen for bowel cancer, but uptake is low (40.9%). The SMARTscreen trial demonstrated th…
View article: Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk
Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk Open
Menopausal users of hormone replacement therapy (HRT) are at increased breast cancer risk and decreased colorectal cancer (CRC) risk compared with individuals who have never used HRT, but these opposing associations may differ by familial …
View article: Causal debiasing for unknown bias in histopathology—A colon cancer use case
Causal debiasing for unknown bias in histopathology—A colon cancer use case Open
Advancement of AI has opened new possibility for accurate diagnosis and prognosis using digital histopathology slides which not only saves hours of expert effort but also makes the estimation more standardized and accurate. However, preser…
View article: Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study
Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study Open
The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian rand…
View article: Hormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in <i>BRCA1</i> and <i>BRCA2</i>
Hormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in <i>BRCA1</i> and <i>BRCA2</i> Open
PURPOSE It is uncertain whether, and to what extent, hormonal contraceptives increase breast cancer (BC) risk for germline BRCA1 or BRCA2 mutation carriers. METHODS Using pooled observational data from four prospective cohort studies, asso…
View article: Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer
Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer Open
The incidence of colorectal cancer (CRC) among individuals under age 50, or early-onset CRC (EOCRC), has been rising over the past few decades for unclear reasons, and the etiology of the disease remains largely unknown. Known genetic risk…
View article: Table S2 from Using DEPendency of association on the number of Top Hits (DEPTH) as a complementary tool to identify novel colorectal cancer susceptibility loci.
Table S2 from Using DEPendency of association on the number of Top Hits (DEPTH) as a complementary tool to identify novel colorectal cancer susceptibility loci. Open
Supplementary Table S2 shows the QC and harmonisation steps for both the GECCO and CCFR datasets