Jenna Cava
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View article: Change in Cone Structure Over 24 Months in USH2A-Related Retinal Degeneration
Change in Cone Structure Over 24 Months in USH2A-Related Retinal Degeneration Open
Using current methods, the analysis of quantitative measures of cone structure showed some challenges, yet showed promise that AOSLO images can be used to characterize progressive change over 24 months. Additional multicenter studies using…
View article: Extracting spacing-derived estimates of rod density in healthy retinae
Extracting spacing-derived estimates of rod density in healthy retinae Open
Quantification of the rod photoreceptor mosaic using adaptive optics scanning light ophthalmoscopy (AOSLO) remains challenging. Here we demonstrate a method for deriving estimates of rod density and rod:cone ratio based on measures of rod …
View article: Intergrader agreement of foveal cone topography measured using adaptive optics scanning light ophthalmoscopy
Intergrader agreement of foveal cone topography measured using adaptive optics scanning light ophthalmoscopy Open
The foveal cone mosaic can be directly visualized using adaptive optics scanning light ophthalmoscopy (AOSLO). Previous studies in individuals with normal vision report wide variability in the topography of the foveal cone mosaic, especial…
View article: Spacing-derived ROIs
Spacing-derived ROIs Open
This dataset is comprised of 105 confocal and split detection ROIs used to estimate spacing-derived rod density (because there was incomplete visualization of the rod mosaic). Additionally, the corresponding cone and rod coordinate files a…
View article: Dataset 2.zip
Dataset 2.zip Open
AOSLO regions of interest (ROIs) and their corresponding rod and cone coordinate files for the 105 ROIs in which rod density was estimated using the spacing-derived method described here.
View article: Datafile2_SpacingDerivedRodMetrics.csv
Datafile2_SpacingDerivedRodMetrics.csv Open
Rod and cone metrics from ROIs with incomplete visualization of the rod mosaic. Rod metrics were calculated from estimates of rod spacing.
View article: Datafile1_DirectCountRodMetrics.csv
Datafile1_DirectCountRodMetrics.csv Open
Rod and cone metrics from ROIs with complete visualization of rod mosaic
View article: Dataset 1.zip
Dataset 1.zip Open
AOSLO regions of interest (ROIs) and their corresponding rod and cone coordinate files for the 22 ROIs in which the rod mosaic could be completely visualized. Data are included for four graders, each making two sets of measurements.
View article: Direct count ROIs
Direct count ROIs Open
This dataset contains 22 confocal and 22 split detection ROIs where the rod mosaic was completely visualized. These data correspond to Figures 3, 4, and 6 as well as Table 2. There are 22 rod coordinate files that were used to provide dire…
View article: Cone photoreceptor reflectance variation in the northern tree shrew and thirteen-lined ground squirrel
Cone photoreceptor reflectance variation in the northern tree shrew and thirteen-lined ground squirrel Open
In vivo images of human cone photoreceptors have been shown to vary in their reflectance both spatially and temporally. While it is generally accepted that the unique anatomy and physiology of the photoreceptors themselves drives this beha…
View article: Retinal alterations in patients with Lafora disease
Retinal alterations in patients with Lafora disease Open
This multimodal retinal imaging approach allowed us to observe a number of retinal structural features in all three individuals. Most notably, AOSLO revealed nummular reflectivity within the inner retina of each subject. This phenotype has…
View article: Automated image processing pipeline for adaptive optics scanning light ophthalmoscopy
Automated image processing pipeline for adaptive optics scanning light ophthalmoscopy Open
To mitigate the substantial post-processing burden associated with adaptive optics scanning light ophthalmoscopy (AOSLO), we have developed an open-source, automated AOSLO image processing pipeline with both “live” and “full” modes. The li…
View article: Assessing Interocular Symmetry of the Foveal Cone Mosaic
Assessing Interocular Symmetry of the Foveal Cone Mosaic Open
There is interocular symmetry of peak foveal cone density, mosaic regularity, and area encompassing the most densely packed cells in subjects with normal vision. The origin and significance of the observed interocular difference in average…
View article: Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics
Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics Open
A better characterization of the confounds surrounding OCT-A retinal vasculature metrics can lead to improved application of these metrics as biomarkers for retinal and systemic diseases.
View article: Preservation of the Foveal Avascular Zone in Achromatopsia Despite the Absence of a Fully Formed Pit
Preservation of the Foveal Avascular Zone in Achromatopsia Despite the Absence of a Fully Formed Pit Open
Our data demonstrate that despite the presence of foveal hypoplasia, patients with ACHM can have a FAZ. This is distinct from other conditions associated with foveal hypoplasia, which generally show an absence of the FAZ. In ACHM, FAZ form…
View article: On the axial location of Gunn's dots
On the axial location of Gunn's dots Open
Based upon evidence from this study and others, Gunn's dots are not thought to be Müller cell end-feet or hyalocytes. We hypothesize that they are related to microglia, either as the by-product of their phagocytosis function, or are actual…
View article: Interocular symmetry, intraobserver repeatability, and interobserver reliability of cone density measurements in the 13-lined ground squirrel
Interocular symmetry, intraobserver repeatability, and interobserver reliability of cone density measurements in the 13-lined ground squirrel Open
Interocular symmetry with repeatable cone density measurements suggest that the 13-LGS is well-suited for longitudinal examination of the cone mosaic using split-detection AOSLO. Differences in reliability highlight the importance of obser…