Jenna E. Foderaro
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View article: The potent <i>Toxoplasma gondii</i> growth inhibitor QQ-437 does not bind to its predicted target, parasite adaptin3<i>β</i>, in yeast three-hybrid assays
The potent <i>Toxoplasma gondii</i> growth inhibitor QQ-437 does not bind to its predicted target, parasite adaptin3<i>β</i>, in yeast three-hybrid assays Open
New drugs are needed to treat infections with Toxoplasma gondii , a ubiquitous protozoan parasite that can cause miscarriage, blindness, and life-threatening encephalitis in its human hosts. A novel N-benzoyl-2-hydroxybenzamide named QQ-43…
View article: Differential Roles of a Family of Flavodoxin-Like Proteins That Promote Resistance to Quinone-Mediated Oxidative Stress in Candida albicans
Differential Roles of a Family of Flavodoxin-Like Proteins That Promote Resistance to Quinone-Mediated Oxidative Stress in Candida albicans Open
Survival of the fungal pathogen Candida albicans within a mammalian host relies on its ability to resist oxidative stress. The four flavodoxin-like proteins (Pst1, Pst2, Pst3, and Ycp4) that reside on the inner surface of the C. albicans p…
View article: Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi
Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi Open
There is growing appreciation that the plasma membrane orchestrates a diverse array of functions by segregating different activities into specialized domains that vary in size, stability, and composition. Studies with the budding yeast Sac…
View article: MCC/Eisosomes Regulate Cell Wall Synthesis and Stress Responses in Fungi
MCC/Eisosomes Regulate Cell Wall Synthesis and Stress Responses in Fungi Open
The fungal plasma membrane is critical for cell wall synthesis and other important processes including nutrient uptake, secretion, endocytosis, morphogenesis, and response to stress. To coordinate these diverse functions, the plasma membra…
View article: Yeast Three-Hybrid Screen Identifies TgBRADIN/GRA24 as a Negative Regulator of Toxoplasma gondii Bradyzoite Differentiation
Yeast Three-Hybrid Screen Identifies TgBRADIN/GRA24 as a Negative Regulator of Toxoplasma gondii Bradyzoite Differentiation Open
Differentiation of the protozoan parasite Toxoplasma gondii into its latent bradyzoite stage is a key event in the parasite's life cycle. Compound 2 is an imidazopyridine that was previously shown to inhibit the parasite lytic cycle, in pa…